Protein: LRP2
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)

Gene: LRP2
Organism: Homo sapiens
Interactions: 139
UniProt ID: P98164

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0001822 - kidney development
GO:0001843 - neural tube closure
GO:0003139 - secondary heart field specification
GO:0003148 - outflow tract septum morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

674651

AMRP
Alpha-2-macroglobulin receptor-associated protein

5

10

Small-scale

0.928

High

957637

SOST
Sclerostin

2

6

High-throughput

0.811

High

957638

PDGFD
Platelet-derived growth factor D

2

5

High-throughput

0.726

High

957098

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

2

High-throughput

0.691

High

957618

DLK2
Protein delta homolog 2

1

3

High-throughput

0.691

High

957623

EGFL6
Epidermal growth factor-like protein 6

1

9

High-throughput

0.691

High

158175

GIPC1
PDZ domain-containing protein GIPC1

3

3

Small-scale

0.658

High

500768

CLUS
Clusterin

3

3

Small-scale

0.655

High

341498

UROK
Urokinase-type plasminogen activator

1

7

Small-scale

0.647

High

362633

APOH
Beta-2-glycoprotein 1

1

5

Small-scale

0.647

High

434638

TSP1
Thrombospondin-1

1

4

Small-scale

0.647

High

411355

INSR
Insulin receptor

1

12

High-throughput

0.646

High

942324

DLG4
Disks large homolog 4

2

8

Small-scale

0.633

High

351843

VIP
VIP peptides [Cleaved into: Intestinal peptide PHV-42

2

1

High-throughput

0.628

High

664383

CCN2
CCN family member 2

2

3

High-throughput

0.628

High

957630

NET5
Netrin-5

1

11

High-throughput

0.618

High

957662

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

20

Small-scale

0.609

High

957629

ZFP41
Zinc finger protein 41 homolog

3

17

High-throughput

0.609

High

957605

RHG19
Rho GTPase-activating protein 19

2

0

High-throughput

0.602

High

957643

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

900376

RHOA
Transforming protein RhoA

2

12

Small-scale

0.595

High

304540

PRS23
Serine protease 23

1

0

High-throughput

0.586

High

200250

ZN264
Zinc finger protein 264

2

2

High-throughput

0.574

High

957620

TAFA3
Chemokine-like protein TAFA-3

2

8

High-throughput

0.574

High

957625

ZSC29
Zinc finger and SCAN domain-containing protein 29

2

8

High-throughput

0.574

High

957644

ZN408
Zinc finger protein 408

2

11

High-throughput

0.574

High

957654

ZN224
Zinc finger protein 224

2

4

High-throughput

0.574

High

957165

DAB2
Disabled homolog 2

1

20

Small-scale

0.573

High

957612

ARH
Low density lipoprotein receptor adapter protein 1

1

20

Small-scale

0.573

High

957645

ANRA2
Ankyrin repeat family A protein 2

2

5

Small-scale

0.571

High

269134

DAB1
Disabled homolog 1

2

20

Small-scale

0.561

High

957599

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

20

Small-scale

0.556

High

957603

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.541

High

449242

LEG1
Galectin-1

1

6

High-throughput

0.536

High

572508

IBP3
Insulin-like growth factor-binding protein 3

1

4

High-throughput

0.536

High

599562

SYT1
Synaptotagmin-1

1

3

High-throughput

0.536

High

957598

EMX2
Homeobox protein EMX2

1

1

High-throughput

0.536

High

957604

MAP7
Ensconsin

1

2

High-throughput

0.536

High

957624

SULF2
Extracellular sulfatase Sulf-2

1

2

High-throughput

0.536

High

957627

FGRL1
Fibroblast growth factor receptor-like 1

1

1

High-throughput

0.536

High

957639

CXL16
C-X-C motif chemokine 16

1

1

High-throughput

0.536

High

957659

FBX2
F-box only protein 2

1

6

High-throughput

0.536

High

152738

ITBP1
Integrin beta-1-binding protein 1

1

2

Small-scale

0.527

High

957634

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

9

Small-scale

0.527

High

166552

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.513

High

351821

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

1

0

High-throughput

0.513

High

380991

SEMG1
Semenogelin-1

1

0

High-throughput

0.513

High

606842

IL10
Interleukin-10

1

0

High-throughput

0.513

High

957600

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

957609

NPTX1
Neuronal pentraxin-1

1

0

High-throughput

0.513

High

957616

ALKL2
ALK and LTK ligand 2

1

0

High-throughput

0.513

High

361475

APOE
Apolipoprotein E

1

7

Small-scale

0.501

High

394536

A4
Amyloid-beta precursor protein

1

12

Small-scale

0.501

High

420665

LIPL
Lipoprotein lipase

1

6

Small-scale

0.501

High

893898

CDC42
Cell division control protein 42 homolog

1

12

Small-scale

0.501

High

925190

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

Small-scale

0.501

High

957606

SNX17
Sorting nexin-17

1

4

Small-scale

0.501

High

614294

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

High-throughput

0.493

High

49242

FEZF1
Fez family zinc finger protein 1

1

13

High-throughput

0.489

High

225927

FGF17
Fibroblast growth factor 17

1

1

High-throughput

0.489

High

485342

GLI4
Zinc finger protein GLI4

1

11

High-throughput

0.489

High

726510

TIMP3
Metalloproteinase inhibitor 3

1

4

High-throughput

0.489

High

957617

IGFL3
Insulin growth factor-like family member 3

1

6

High-throughput

0.489

High

957619

ZN517
Zinc finger protein 517

1

17

High-throughput

0.489

High

957626

AN36B
Ankyrin repeat domain-containing protein 36B

1

8

High-throughput

0.489

High

957632

TAFA4
Chemokine-like protein TAFA-4

1

8

High-throughput

0.489

High

957641

GREM2
Gremlin-2

1

2

High-throughput

0.489

High

957653

IL20
Interleukin-20

1

1

High-throughput

0.489

High

957657

DKK2
Dickkopf-related protein 2

1

8

High-throughput

0.489

High

869452

ATN1
Atrophin-1

1

0

High-throughput

0.486

High

253552

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

20

Small-scale

0.481

High

883907

SYJ2B
Synaptojanin-2-binding protein

1

18

Small-scale

0.481

High

957656

LR2BP
LRP2-binding protein

1

2

Small-scale

0.481

High

957608

DLG2
Disks large homolog 2

1

8

Small-scale

0.481

High

957621

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

4

Small-scale

0.481

High

957631

DLG3
Disks large homolog 3

1

8

Small-scale

0.481

High

957636

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

12

Small-scale

0.481

High

957650

SCN3A
Sodium channel protein type 3 subunit alpha

1

3

Small-scale

0.481

High

514327

UTER
Uteroglobin

1

0

Small-scale

0.480

High

178484

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

319170

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.479

High

337431

ABL1
Tyrosine-protein kinase ABL1

1

1

High-throughput

0.479

High

350073

RASK
GTPase KRas

1

12

High-throughput

0.479

High

364008

VTDB
Vitamin D-binding protein

1

1

Small-scale

0.479

High

525900

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

527391

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.479

High

531794

PDIA4
Protein disulfide-isomerase A4

1

6

High-throughput

0.479

High

564477

RHOQ
Rho-related GTP-binding protein RhoQ

1

15

High-throughput

0.479

High

567009

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

591814

RAB4A
Ras-related protein Rab-4A

1

9

High-throughput

0.479

High

592200

RAB5A
Ras-related protein Rab-5A

1

8

High-throughput

0.479

High

716993

CTNB1
Catenin beta-1

1

3

High-throughput

0.479

High

844482

RAB5C
Ras-related protein Rab-5C

1

8

High-throughput

0.479

High

844876

RAB7A
Ras-related protein Rab-7a

1

9

High-throughput

0.479

High

845438

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.479

High

890105

SC61B
Protein transport protein Sec61 subunit beta

1

3

High-throughput

0.479

High

895038

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.479

High

914007

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.479

High

945656

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

Small-scale

0.479

High

957597

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

957602

CUL3
Cullin-3

1

10

High-throughput

0.479

High

957607

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.479

High

957615

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

957633

ZDH15
Palmitoyltransferase ZDHHC15

1

1

Small-scale

0.479

High

957658

HOOK1
Protein Hook homolog 1

1

2

High-throughput

0.479

High

957661

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.479

High

957663

LAMP3
Lysosome-associated membrane glycoprotein 3

1

4

High-throughput

0.479

High

920755

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

957601

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

957635

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

957642

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

435042

SP1
Transcription factor Sp1

1

14

High-throughput

0.457

High

957660

APC10
Anaphase-promoting complex subunit 10

1

3

Small-scale

0.439

High

420779

CALCA
Calcitonin gene-related peptide 1

1

1

High-throughput

0.437

High

575373

EGR1
Early growth response protein 1

1

7

High-throughput

0.437

High

957614

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.437

High

957622

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

957651

OBP2A
Odorant-binding protein 2a

1

1

High-throughput

0.437

High

957652

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

4

High-throughput

0.437

High

413086

AGAL
Alpha-galactosidase A

1

0

Small-scale

0.426

High

351791

CALC
Calcitonin [Cleaved into: Calcitonin; Katacalcin

1

1

High-throughput

0.407

High

800348

CBX5
Chromobox protein homolog 5

1

1

Small-scale

0.407

High

957648

MEPE
Matrix extracellular phosphoglycoprotein

2

0

High-throughput

0.328

High

957655

TAP26
Thyroid transcription factor 1-associated protein 26

2

0

High-throughput

0.328

High

957665

INSL6
Insulin-like peptide INSL6

2

0

High-throughput

0.328

High

957647

AMBN
Ameloblastin

2

0

High-throughput

0.324

High

957640

RIBC2
RIB43A-like with coiled-coils protein 2

2

0

High-throughput

0.319

High

159758

LECT2
Leukocyte cell-derived chemotaxin-2

1

0

High-throughput

0.279

Low

485234

TZAP
Telomere zinc finger-associated protein

1

0

High-throughput

0.279

Low

957610

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.279

Low

957613

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

1

0

High-throughput

0.279

Low

957628

DB125
Beta-defensin 125

1

0

High-throughput

0.279

Low

957646

WFDC1
WAP four-disulfide core domain protein 1

1

0

High-throughput

0.279

Low

799967

VDAC2
Voltage-dependent anion-selective channel protein 2

1

0

High-throughput

0.269

Low

450562

RET1
Retinol-binding protein 1

1

0

Small-scale

0.261

Low

957649

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

0

Small-scale

0.251

Low

270023

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.249

Low

957611

RNS13
Probable inactive ribonuclease-like protein 13

1

0

High-throughput

0.249

Low

957664

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024