HitPredict

Interactor 1: RPN12 (P32496)
26S proteasome regulatory subunit RPN12 (Nuclear integrity protein 1)
Gene: RPN12

Interactor 2: PRS6B (P33298)
26S proteasome regulatory subunit 6B homolog (Protein YNT1) (Tat-binding homolog 2)
Gene: RPT3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.731

Property	Details
Experiments	11805826, 11805837, 37968396, 16429126, 31848235, 11742986
Identification Methods	tandem affinity purification, anti tag coimmunoprecipitation, affinity chromatography technology, cross-linking study, two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 274 Sc			1 428
+	At
		1456454 PSD8A_ARATH (2-274): 3.1e-93: 277: 28.06		PRS4A_ARATH (44-419): 3.96e-157: 452: 46.83
+	Hs
		874138 PSMD8_HUMAN (16-274): 3.1e-101: 300: 31.27		PRS4_HUMAN (15-427): 1.84e-124: 369: 44.34
+	Hs
		851264 PSMD8_HUMAN (16-274): 3.1e-101: 300: 31.27		PRS6B_HUMAN (1-428): 1.07e-122: 364: 65.42
+	Hs
		874142 PSMD8_HUMAN (16-274): 3.1e-101: 300: 31.27		PRS10_HUMAN (42-426): 6.2e-123: 363: 37.66
+	Hs
		874139 PSMD8_HUMAN (16-274): 3.1e-101: 300: 31.27		PRS8_HUMAN (30-423): 5.55e-119: 354: 39.59
+	Sc
		738315 RPN12_YEAST (1-274): 3.73e-102: 300: 100.00		PRS4_YEAST (49-410): 4.58e-110: 332: 47.53
+	Dm
		1464848 Q9V436_DROME (1-274): 2.48e-78: 239: 26.72		Q9V405_DROME (45-428): 5.31e-121: 359: 72.66