Protein: RPN12
26S proteasome regulatory subunit RPN12 (Nuclear integrity protein 1)

Gene: RPN12
Organism: Saccharomyces cerevisiae S288C
Interactions: 99
UniProt ID: P32496

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008541 - proteasome regulatory particle, lid subcomplex
GO:0034515 - proteasome storage granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738345

RPN8
26S proteasome regulatory subunit RPN8

9

5

Small-scale

0.976

High

738347

RPN5
26S proteasome regulatory subunit RPN5

10

4

Small-scale

0.975

High

738341

RPN7
26S proteasome regulatory subunit RPN7

10

4

Small-scale

0.975

High

738310

RPN3
26S proteasome regulatory subunit RPN3

8

3

Small-scale

0.969

High

738348

RPN6
26S proteasome regulatory subunit RPN6

9

3

Small-scale

0.967

High

738336

RPN9
26S proteasome regulatory subunit RPN9

7

3

Small-scale

0.962

High

738322

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

29

6

Small-scale

0.767

High

738285

RPN12
26S proteasome regulatory subunit RPN12

2

1

High-throughput

0.754

High

738292

PRS7
26S proteasome regulatory subunit 7 homolog

9

8

Small-scale

0.752

High

645141

PSB4
Proteasome subunit beta type-4

9

8

Small-scale

0.750

High

738305

RPN10
26S proteasome regulatory subunit RPN10

7

2

Small-scale

0.747

High

738304

RPN1
26S proteasome regulatory subunit RPN1

8

7

Small-scale

0.746

High

738333

PRS8
26S proteasome regulatory subunit 8 homolog

6

9

Small-scale

0.732

High

738291

PRS6B
26S proteasome regulatory subunit 6B homolog

6

7

Small-scale

0.731

High

738286

RPN2
26S proteasome regulatory subunit RPN2

6

7

Small-scale

0.729

High

738289

RAD23
UV excision repair protein RAD23

5

8

Small-scale

0.703

High

738315

PRS4
26S proteasome regulatory subunit 4 homolog

4

9

High-throughput

0.694

High

738331

PRS10
26S proteasome subunit RPT4

4

9

High-throughput

0.694

High

738290

PRS6A
26S proteasome regulatory subunit 6A

4

9

High-throughput

0.691

High

738328

PSD10
Probable 26S proteasome regulatory subunit p28

4

1

Small-scale

0.689

High

314853

SEM1
26S proteasome complex subunit SEM1

5

0

Small-scale

0.679

High

738298

HSM3
DNA mismatch repair protein HSM3

5

0

Small-scale

0.676

High

738303

ECM29
Proteasome component ECM29

3

1

High-throughput

0.662

High

738313

PSA6
Proteasome subunit alpha type-6

3

6

High-throughput

0.662

High

738314

PSA4
Proteasome subunit alpha type-4

3

4

Small-scale

0.640

High

738323

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

2

1

High-throughput

0.601

High

738330

RPN14
26S proteasome regulatory subunit RPN14

2

1

High-throughput

0.594

High

636554

PSA7
Probable proteasome subunit alpha type-7

2

7

Small-scale

0.586

High

661386

PSA3
Proteasome subunit alpha type-3

2

4

Small-scale

0.586

High

150272

RPN13
26S proteasome regulatory subunit RPN13

2

0

High-throughput

0.585

High

636642

PSA1
Proteasome subunit alpha type-1

2

4

High-throughput

0.584

High

661480

PSA2
Proteasome subunit alpha type-2

2

4

High-throughput

0.584

High

668372

PSB2
Proteasome subunit beta type-2

2

5

Small-scale

0.584

High

738340

DON1
Donuts protein 1

2

0

High-throughput

0.565

High

738334

RPN4
Protein RPN4

2

0

Small-scale

0.559

High

544183

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

738287

HSP7F
Heat shock protein homolog SSE1

2

1

High-throughput

0.552

High

738324

LSM8
LSM2-LSM8 complex subunit LSM8

1

1

High-throughput

0.536

High

726031

FUN30
ATP-dependent helicase FUN30

1

1

High-throughput

0.515

High

509455

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

625073

PRP9
Pre-mRNA-splicing factor PRP9

1

0

High-throughput

0.493

High

734394

BTAF1
TATA-binding protein-associated factor MOT1

1

0

High-throughput

0.493

High

738288

TOR2
Serine/threonine-protein kinase TOR2

1

0

High-throughput

0.493

High

738294

TFC3
Transcription factor tau 138 kDa subunit

1

0

High-throughput

0.493

High

738339

CSM3
Chromosome segregation in meiosis protein 3

1

0

High-throughput

0.493

High

738351

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.493

High

662026

PSB6
Proteasome subunit beta type-6

1

8

High-throughput

0.479

High

675233

PSB3
Proteasome subunit beta type-3

1

7

High-throughput

0.479

High

679486

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

721238

PSB5
Proteasome subunit beta type-5

1

6

High-throughput

0.479

High

721291

PSB7
Proteasome subunit beta type-7

1

6

High-throughput

0.479

High

735906

PSA5
Proteasome subunit alpha type-5

1

3

High-throughput

0.479

High

738299

PSB1
Proteasome subunit beta type-1

1

6

High-throughput

0.479

High

738300

STS1
Tethering factor for nuclear proteasome STS1

1

1

Small-scale

0.479

High

738311

DDI1
DNA damage-inducible protein 1

1

1

Small-scale

0.479

High

738318

PSMD9
Probable 26S proteasome regulatory subunit p27

1

2

Small-scale

0.479

High

738326

DSK2
Ubiquitin domain-containing protein DSK2

1

9

Small-scale

0.479

High

738344

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

0

Small-scale

0.460

High

434928

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

445326

CDC31
Cell division control protein 31

1

0

Small-scale

0.458

High

594255

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

670473

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

706518

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

738295

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

738319

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

738321

BLM10
Proteasome activator BLM10

1

0

High-throughput

0.458

High

738329

INO80
Chromatin-remodeling ATPase INO80

1

0

Small-scale

0.458

High

738332

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

High-throughput

0.458

High

738338

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.458

High

738342

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

738350

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.458

High

738312

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

616399

SEC18
Vesicular-fusion protein SEC18

1

2

High-throughput

0.437

High

738309

PAC2
Protein PAC2

1

2

Small-scale

0.437

High

738317

MLP2
Protein MLP2

1

1

High-throughput

0.437

High

526188

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

738320

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

738335

ESC1
Silent chromatin protein ESC1

2

0

High-throughput

0.305

High

639547

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.279

Low

738337

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.279

Low

738349

LAS17
Proline-rich protein LAS17

1

0

High-throughput

0.279

Low

481868

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.269

Low

632542

DBP3
ATP-dependent RNA helicase DBP3

1

0

High-throughput

0.269

Low

738301

KIC1
Serine/threonine-protein kinase KIC1

1

0

High-throughput

0.269

Low

738306

VPS45
Vacuolar protein sorting-associated protein 45

1

0

High-throughput

0.269

Low

738307

MPT5
Suppressor protein MPT5

1

0

High-throughput

0.269

Low

738308

ERV46
ER-derived vesicles protein ERV46

1

0

High-throughput

0.269

Low

738325

XPT1
Xanthine phosphoribosyltransferase 1

1

0

High-throughput

0.265

Low

579049

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

738293

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

738297

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.249

Low

738316

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

1

0

High-throughput

0.249

Low

738327

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

738343

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

738346

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

531278

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.232

Low

738296

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.232

Low

738302

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025