Protein: PSMD8
26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31)

Gene: PSMD8
Organism: Homo sapiens
Interactions: 136
UniProt ID: P48556

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005838 - proteasome regulatory particle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

210886

PSMD3
26S proteasome non-ATPase regulatory subunit 3

11

3

Small-scale

0.975

High

874131

PSMD7
26S proteasome non-ATPase regulatory subunit 7

4

5

High-throughput

0.892

High

128175

PSD12
26S proteasome non-ATPase regulatory subunit 12

2

4

High-throughput

0.811

High

874210

PSD13
26S proteasome non-ATPase regulatory subunit 13

2

3

High-throughput

0.802

High

874213

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

8

2

Small-scale

0.746

High

138012

PSDE
26S proteasome non-ATPase regulatory subunit 14

7

6

Small-scale

0.739

High

874125

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

1

High-throughput

0.724

High

874135

PSMD4
26S proteasome non-ATPase regulatory subunit 4

5

2

Small-scale

0.719

High

851264

PRS6B
26S proteasome regulatory subunit 6B

4

8

Small-scale

0.694

High

874157

ADRM1
Proteasomal ubiquitin receptor ADRM1

4

1

High-throughput

0.694

High

874138

PRS4
26S proteasome regulatory subunit 4

4

9

Small-scale

0.686

High

700501

PSB9
Proteasome subunit beta type-9

3

6

High-throughput

0.667

High

874162

CCD92
Coiled-coil domain-containing protein 92

4

0

High-throughput

0.667

High

874155

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

4

High-throughput

0.665

High

610262

PRS6A
26S proteasome regulatory subunit 6A

3

10

Small-scale

0.656

High

874139

PRS8
26S proteasome regulatory subunit 8

3

8

Small-scale

0.656

High

778629

PRS7
26S proteasome regulatory subunit 7

3

5

Small-scale

0.640

High

874145

UBE3A
Ubiquitin-protein ligase E3A

3

1

Small-scale

0.640

High

159558

DVL2
Segment polarity protein dishevelled homolog DVL-2

3

0

High-throughput

0.638

High

874158

PSMD5
26S proteasome non-ATPase regulatory subunit 5

3

0

Small-scale

0.634

High

874132

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

3

1

Small-scale

0.633

High

295471

PSD10
26S proteasome non-ATPase regulatory subunit 10

2

1

High-throughput

0.628

High

874127

PSB3
Proteasome subunit beta type-3

2

9

High-throughput

0.628

High

874179

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

2

1

Small-scale

0.611

High

874188

CC74B
Coiled-coil domain-containing protein 74B

3

1

High-throughput

0.609

High

874150

PSMD2
26S proteasome non-ATPase regulatory subunit 2

2

7

High-throughput

0.601

High

874193

PAAF1
Proteasomal ATPase-associated factor 1

2

1

Small-scale

0.601

High

507670

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

3

High-throughput

0.595

High

241046

PRKN
E3 ubiquitin-protein ligase parkin

2

2

Small-scale

0.584

High

607548

PTN2
Tyrosine-protein phosphatase non-receptor type 2

2

1

High-throughput

0.584

High

874142

PRS10
26S proteasome regulatory subunit 10B

2

8

Small-scale

0.584

High

716258

PRDX6
Peroxiredoxin-6

2

0

High-throughput

0.580

High

874180

SHC3
SHC-transforming protein 3

2

0

High-throughput

0.580

High

529322

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.571

High

874136

SEM1
26S proteasome complex subunit SEM1

2

0

Small-scale

0.559

High

874172

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

0

High-throughput

0.559

High

128397

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

2

High-throughput

0.536

High

874167

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.536

High

874181

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.536

High

874147

TP53B
TP53-binding protein 1

1

0

High-throughput

0.529

High

287667

KS6A5
Ribosomal protein S6 kinase alpha-5

1

0

High-throughput

0.513

High

539973

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.513

High

563405

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

733751

FOXN2
Forkhead box protein N2

1

0

High-throughput

0.513

High

874174

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.513

High

874176

BBS5
BBSome complex member BBS5

1

0

High-throughput

0.513

High

874192

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.513

High

874207

INTU
Protein inturned

1

0

High-throughput

0.513

High

181863

SMAD9
Mothers against decapentaplegic homolog 9

1

1

High-throughput

0.508

High

874129

GSK3A
Glycogen synthase kinase-3 alpha

1

3

High-throughput

0.508

High

874130

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.508

High

874156

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.508

High

339683

KLF8
Krueppel-like factor 8

1

1

High-throughput

0.500

High

874194

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.500

High

155091

SOCS2
Suppressor of cytokine signaling 2

1

0

High-throughput

0.493

High

773126

MYH10
Myosin-10

1

0

High-throughput

0.493

High

874177

ARRD4
Arrestin domain-containing protein 4

1

1

High-throughput

0.489

High

874178

ARRD2
Arrestin domain-containing protein 2

1

1

High-throughput

0.489

High

874182

CC74A
Coiled-coil domain-containing protein 74A

1

1

High-throughput

0.489

High

605179

TAL1
T-cell acute lymphocytic leukemia protein 1

1

0

High-throughput

0.479

High

425371

ISG15
Ubiquitin-like protein ISG15

1

4

Small-scale

0.479

High

659399

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

667633

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

681121

PSA2
Proteasome subunit alpha type-2

1

5

Small-scale

0.479

High

874133

RD23A
UV excision repair protein RAD23 homolog A

1

7

Small-scale

0.479

High

874134

RD23B
UV excision repair protein RAD23 homolog B

1

9

High-throughput

0.479

High

874143

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

874159

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.479

High

874164

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.479

High

874166

DDI2
Protein DDI1 homolog 2

1

8

High-throughput

0.479

High

874199

MYO10
Unconventional myosin-X

1

1

Small-scale

0.479

High

874200

UBQL4
Ubiquilin-4

1

9

Small-scale

0.479

High

874205

UBQL2
Ubiquilin-2

1

5

High-throughput

0.479

High

874209

UBQL1
Ubiquilin-1

1

6

High-throughput

0.479

High

874211

RNF11
RING finger protein 11

1

1

Small-scale

0.479

High

874212

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

282172

MAF
Transcription factor Maf

1

0

Small-scale

0.458

High

315264

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

319514

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

320637

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

347573

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

349002

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

588166

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

629649

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

694889

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

731072

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

766146

NOS2
Nitric oxide synthase, inducible

1

0

High-throughput

0.458

High

767663

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

830324

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

874137

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

874140

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

874141

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

874144

H31
Histone H3.1

1

0

High-throughput

0.458

High

874146

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

874148

TRI26
Tripartite motif-containing protein 26

1

0

Small-scale

0.458

High

874149

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

874151

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.458

High

874152

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

874160

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

874161

MIDN
Midnolin

1

0

High-throughput

0.458

High

874168

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

874169

DESI1
Desumoylating isopeptidase 1

1

0

Small-scale

0.458

High

874175

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.458

High

874185

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

0

Small-scale

0.458

High

874186

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

874187

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

874191

PFD5
Prefoldin subunit 5

1

0

Small-scale

0.458

High

874196

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

0

Small-scale

0.458

High

874201

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.458

High

874202

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

874203

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.458

High

874204

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

874206

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.458

High

874208

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

874128

PSB2
Proteasome subunit beta type-2

1

8

Small-scale

0.445

High

874171

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

874183

RN185
E3 ubiquitin-protein ligase RNF185

1

2

Small-scale

0.437

High

429507

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

874163

TMM31
Transmembrane protein 31

2

0

High-throughput

0.313

High

874195

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

874198

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

874126

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

846042

GLP1R
Glucagon-like peptide 1 receptor

1

0

Small-scale

0.251

Low

293361

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

411558

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

705687

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

0

High-throughput

0.249

Low

874153

PTC1
Protein patched homolog 1

1

0

Small-scale

0.249

Low

874154

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

874170

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

874173

GOLI
E3 ubiquitin-protein ligase RNF130

1

0

High-throughput

0.249

Low

874184

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

874189

RN157
E3 ubiquitin ligase RNF157

1

0

Small-scale

0.249

Low

874197

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

874165

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

874190

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025