HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	11278251, 14657019, 12857866
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0046332 - SMAD binding GO:0070411 - I-SMAD binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 503 Hs			1 757
+	Hs
		981139 ACVR1_HUMAN (10-500): 8.17e-136: 403: 49.30		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		122298 BMR1B_HUMAN (22-503): 1.21e-134: 400: 51.53		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		738413 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		738495 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		740065 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		738578 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Mm
		1143778 TGFR2_MOUSE (38-499): 3.76e-121: 368: 32.23		SMUF1_MOUSE (1-757): 0: 855: 95.24
+	Mm
		56831 TGFR1_MOUSE (26-503): 1.83e-145: 428: 97.30		SMUF2_MOUSE (1-757): 0: 795: 71.30
+	Hs
		1046388 BMPR2_HUMAN (48-495): 1.21e-92: 305: 29.21		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		738569 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		740064 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Hs
		738509 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		125195 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		740040 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		738312 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		125199 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		738403 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Hs
		738485 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Dm
		1279501 Q95SI0_DROME (31-497): 6.57e-122: 368: 45.13		SMUF1_DROME (5-293): 2.09e-29: 127: 34.24