HitPredict

Interactor 1: SCNNA (P37088)
Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (ENaCA) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
Gene: SCNN1A

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	14556380
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 669 Hs			1 922
+	Hs
		739603 SCNNA_HUMAN (1-669): 0: 729: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125197 SCNNA_HUMAN (1-669): 0: 729: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		739604 SCNNA_HUMAN (1-669): 0: 729: 100.00		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Rn
		739630 SCNNG_RAT (36-650): 0: 568: 32.75		Q4V8H7_RAT (1-922): 0: 937: 89.91
+	Hs
		739582 SCNNA_HUMAN (1-669): 0: 729: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		125257 SCNNG_HUMAN (36-650): 0: 568: 33.44		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		125256 SCNNB_HUMAN (54-666): 0: 564: 30.54		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		845991 SCNNG_HUMAN (36-650): 0: 568: 33.44		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Mm
		93272 SCNNA_MOUSE (1-665): 0: 661: 82.66		E9PXB7_MOUSE (129-919): 0: 696: 34.71
+	Hs
		808050 SCNNG_HUMAN (36-650): 0: 568: 33.44		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		739597 SCNNA_HUMAN (1-669): 0: 729: 100.00		HUWE1_HUMAN (130-921): 1.4e-172: 559: 24.48
+	Hs
		808049 SCNNB_HUMAN (54-666): 0: 564: 30.54		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Mm
		93286 SCNNG_MOUSE (36-650): 0: 576: 33.12		E9PXB7_MOUSE (129-919): 0: 696: 34.71
+	Rn
		739625 SCNNA_RAT (1-668): 0: 680: 82.74		NEDD4_RAT (10-425): 7.95e-51: 195: 19.38
+	Mm
		808356 SCNNA_MOUSE (1-665): 0: 661: 82.66		NEDD4_MOUSE (3-446): 4.73e-51: 195: 18.83
+	Hs
		739596 SCNNA_HUMAN (1-669): 0: 729: 100.00		HECW1_HUMAN (163-530): 4.01e-13: 76.1: 18.40
+	Mm
		808383 SCNNG_MOUSE (36-650): 0: 576: 33.12		NEDD4_MOUSE (3-446): 4.73e-51: 195: 18.83
+	Rn
		739631 SCNNG_RAT (36-650): 0: 568: 32.75		NEDD4_RAT (10-425): 7.95e-51: 195: 19.38
+	Rn
		739628 SCNNB_RAT (54-666): 0: 566: 31.22		NEDD4_RAT (10-425): 7.95e-51: 195: 19.38
+	Hs
		845975 SCNNB_HUMAN (54-666): 0: 564: 30.54		HECW1_HUMAN (163-530): 4.01e-13: 76.1: 18.40