HitPredict - High confidence protein-protein interactions

Interactor 1: PPARG (P37231)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Interactor 2: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	21664967, 31023188
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific and 24 others more... GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006357 - regulation of transcription by RNA polymerase II GO:0006919 - activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0008270 - zinc ion binding GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression GO:0030154 - cell differentiation GO:0043235 - receptor complex GO:0043565 - sequence-specific DNA binding GO:0045668 - negative regulation of osteoblast differentiation GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050728 - negative regulation of inflammatory response GO:0051091 - positive regulation of DNA-binding transcription factor activity GO:0070412 - R-SMAD binding GO:0140297 - DNA-binding transcription factor binding GO:1902894 - negative regulation of miRNA transcription GO:1902895 - positive regulation of miRNA transcription GO:1903243 - negative regulation of cardiac muscle hypertrophy in response to stress
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1	505
Hs

1	425

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Last updated: 15 Jul 2024