HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	36634849, 32814053
Identification Methods	proximity labelling technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000287 - magnesium ion binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 216
+	Rn
		722751 SYUA_RAT (1-140): 2.23e-57: 176: 95.00		RAB8A_RAT (1-204): 9.08e-80: 239: 24.64
+	Hs
		742523 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		RAB1B_HUMAN (4-195): 1.12e-80: 240: 28.72
+	Mm
		223026 SYUA_MOUSE (1-140): 4.44e-57: 175: 95.00		RAB8A_MOUSE (1-204): 9.08e-80: 239: 24.64
+	Hs
		742177 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		RAB8A_HUMAN (1-203): 1.27e-79: 238: 24.76
+	Hs
		742178 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		RAB10_HUMAN (11-177): 3.9e-29: 109: 33.14