HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: PLK2 (Q9NYY3)
Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase)
Gene: PLK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	34234930, 19889641, 22988096
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process GO:0060291 - long-term synaptic potentiation
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 685
+	Hs
		742152 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		PLK1_HUMAN (88-680): 0: 551: 37.98
+	Hs
		742535 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		PLK3_HUMAN (21-668): 0: 539: 47.85
+	Hs
		861771 SYUB_HUMAN (1-126): 2.84e-36: 122: 58.02		PLK1_HUMAN (88-680): 0: 551: 37.98
+	Hs
		1080932 SYUB_HUMAN (1-126): 2.84e-36: 122: 58.02		PLK3_HUMAN (21-668): 0: 539: 47.85
+	Hs
		742280 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		KCC2G_HUMAN (69-612): 1.3e-150: 450: 21.33