Protein: ESA1
Histone acetyltransferase ESA1 (EC 2.3.1.48) (Protein 2-hydroxyisobutyryltransferase ESA1) (EC 2.3.1.-) (Protein acetyltransferase ESA1) (EC 2.3.1.-) (Protein crotonyltransferase ESA1) (EC 2.3.1.-)

Gene: ESA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 233
UniProt ID: Q08649

Gene Ontology (top 5):
GO:0000183 - rDNA heterochromatin formation
GO:0000785 - chromatin
GO:0000786 - nucleosome
GO:0003682 - chromatin binding
GO:0003712 - transcription coregulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

849813

EPL1
Enhancer of polycomb-like protein 1

26

10

Small-scale

0.990

High

805141

YNG2
Chromatin modification-related protein YNG2

13

20

Small-scale

0.975

High

419897

H2A2
Histone H2A.2

7

13

Small-scale

0.956

High

963767

H3
Histone H3

6

20

Small-scale

0.940

High

419524

H2A1
Histone H2A.1

6

13

Small-scale

0.937

High

1064644

ESA1
Histone acetyltransferase ESA1

4

14

Small-scale

0.868

High

381299

H2B1
Histone H2B.1

3

20

Small-scale

0.834

High

805231

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

19

12

Small-scale

0.764

High

1054842

EAF1
Chromatin modification-related protein EAF1

16

1

Small-scale

0.761

High

1064659

EAF3
Chromatin modification-related protein EAF3

15

13

Small-scale

0.761

High

1010217

ARP4
Actin-related protein 4

16

20

Small-scale

0.761

High

924907

AF9
Protein AF-9 homolog

14

10

Small-scale

0.758

High

918182

SWC4
SWR1-complex protein 4

13

7

Small-scale

0.757

High

948681

ACT
Actin

14

14

Small-scale

0.757

High

1064662

H2AZ
Histone H2A.Z

2

20

Small-scale

0.755

High

382394

H4
Histone H4

10

13

Small-scale

0.754

High

865854

EAF6
Chromatin modification-related protein EAF6

11

1

Small-scale

0.751

High

924591

EAF7
Chromatin modification-related protein EAF7

7

1

Small-scale

0.744

High

381660

H2B2
Histone H2B.2

2

20

Small-scale

0.737

High

816628

EAF5
Chromatin modification-related protein EAF5

11

0

Small-scale

0.722

High

754254

MSN4
Zinc finger protein MSN4

3

5

Small-scale

0.641

High

626544

AP1
AP-1-like transcription factor YAP1

3

0

Small-scale

0.634

High

546573

SSB1
Ribosome-associated molecular chaperone SSB1

3

5

Small-scale

0.624

High

820002

SSB2
Ribosome-associated molecular chaperone SSB2

3

5

Small-scale

0.624

High

739803

SPT16
FACT complex subunit SPT16

2

1

Small-scale

0.585

High

742568

HSP7F
Heat shock protein homolog SSE1

2

10

Small-scale

0.585

High

710023

BMH1
Protein BMH1

2

3

Small-scale

0.584

High

1053919

NHEJ1
Non-homologous end-joining protein 1

2

0

Small-scale

0.577

High

1026846

CDC14
Tyrosine-protein phosphatase CDC14

2

1

Small-scale

0.571

High

550085

RAP1
DNA-binding protein RAP1

1

0

Small-scale

0.561

High

777133

BDF1
Bromodomain-containing factor 1

2

20

Small-scale

0.552

High

836659

GLDS1
Protein GDS1

2

0

Small-scale

0.547

High

924113

CNM67
Chaotic nuclear migration protein 67

2

1

Small-scale

0.543

High

722325

XPO1
Exportin-1

1

2

High-throughput

0.536

High

810778

TCPB
T-complex protein 1 subunit beta

2

3

Small-scale

0.534

High

828515

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.513

High

574822

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

4

Small-scale

0.501

High

647850

RFA1
Replication factor A protein 1

1

2

Small-scale

0.501

High

670348

NAP1
Nucleosome assembly protein

1

7

Small-scale

0.501

High

677252

SPB1
27S pre-rRNA

1

2

Small-scale

0.501

High

727371

HS104
Heat shock protein 104

1

1

Small-scale

0.501

High

736744

ASF1
Histone chaperone ASF1

1

3

Small-scale

0.501

High

739214

PRP19
Pre-mRNA-processing factor 19

1

5

Small-scale

0.501

High

750794

PRS6A
26S proteasome regulatory subunit 6A

1

1

Small-scale

0.501

High

808779

NAB3
Nuclear polyadenylated RNA-binding protein 3

1

1

Small-scale

0.501

High

887768

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

1

Small-scale

0.501

High

893304

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

Small-scale

0.501

High

923031

DBP6
ATP-dependent RNA helicase DBP6

1

6

Small-scale

0.501

High

923929

VPS75
Vacuolar protein sorting-associated protein 75

1

6

Small-scale

0.501

High

1030408

CTF4
DNA polymerase alpha-binding protein

1

8

Small-scale

0.501

High

1038784

SKI8
Antiviral protein SKI8

1

5

Small-scale

0.501

High

1059307

BDF2
Bromodomain-containing factor 2

1

15

Small-scale

0.501

High

644604

APA2
Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2

1

0

Small-scale

0.480

High

692528

GYS2
Glycogen [starch] synthase isoform 2

1

0

Small-scale

0.480

High

735299

IMPX
Sugar utilization regulatory protein IMP2

1

0

Small-scale

0.480

High

744232

GLRX4
Monothiol glutaredoxin-4

1

0

Small-scale

0.480

High

757640

SIP2
SNF1 protein kinase subunit beta-2

1

0

Small-scale

0.480

High

780004

POC2
Proteasome assembly chaperone 2

1

0

Small-scale

0.480

High

780390

ELF1
Transcription elongation factor 1

1

0

Small-scale

0.480

High

807166

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

Small-scale

0.480

High

817200

CHZ1
Histone H2A.Z-specific chaperone CHZ1

1

0

Small-scale

0.480

High

818381

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

0

Small-scale

0.480

High

820306

IES2
Ino eighty subunit 2

1

0

Small-scale

0.480

High

894397

SOL1
6-phosphogluconolactonase-like protein 1

1

0

Small-scale

0.480

High

910800

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.480

High

918246

YG1B
Uncharacterized protein YGR017W

1

0

Small-scale

0.480

High

1040452

UME1
Transcriptional regulatory protein UME1

1

0

Small-scale

0.480

High

1051355

SVF1
Ceramide-binding protein SVF1

1

0

Small-scale

0.480

High

1052616

EFM7
Protein N-terminal and lysine N-methyltransferase EFM7

1

0

Small-scale

0.480

High

1055565

URN1
Pre-mRNA-splicing factor URN1

1

0

Small-scale

0.480

High

1064648

CUB1

1

0

Small-scale

0.480

High

1064649

PLP2
Phosducin-like protein 2

1

0

Small-scale

0.480

High

1064656

HIF1
HAT1-interacting factor 1

1

0

Small-scale

0.480

High

1064658

WHI5
G1-specific transcriptional repressor WHI5

1

0

Small-scale

0.480

High

403683

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

Small-scale

0.479

High

486340

TBA1
Tubulin alpha-1 chain

1

5

Small-scale

0.479

High

518148

SSBP1
Single-stranded nucleic acid-binding protein

1

5

Small-scale

0.479

High

632755

DBP4
ATP-dependent RNA helicase HCA4

1

4

Small-scale

0.479

High

661201

SPT6
Transcription elongation factor SPT6

1

2

Small-scale

0.479

High

694663

SPT5
Transcription elongation factor SPT5

1

1

Small-scale

0.479

High

734486

BTAF1
TATA-binding protein-associated factor MOT1

1

10

Small-scale

0.479

High

736055

SP110
Spindle pole body component 110

1

3

Small-scale

0.479

High

737963

HOG1
Mitogen-activated protein kinase HOG1

1

2

Small-scale

0.479

High

741162

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

2

High-throughput

0.479

High

743150

STH1
Nuclear protein STH1/NPS1

1

7

Small-scale

0.479

High

745626

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

1

Small-scale

0.479

High

751016

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

Small-scale

0.479

High

754191

MSN2
Zinc finger protein MSN2

1

6

Small-scale

0.479

High

760369

BMH2
Protein BMH2

1

3

Small-scale

0.479

High

776662

DEF1
RNA polymerase II degradation factor 1

1

1

Small-scale

0.479

High

791124

NOP4
Nucleolar protein 4

1

2

Small-scale

0.479

High

817973

IMB4
Importin subunit beta-4

1

4

Small-scale

0.479

High

850233

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

2

Small-scale

0.479

High

850595

RSC8
Chromatin structure-remodeling complex protein RSC8

1

1

Small-scale

0.479

High

1039060

IMA1
Importin subunit alpha

1

8

Small-scale

0.479

High

1043984

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

5

Small-scale

0.479

High

1045093

SXM1
Importin beta SMX1

1

1

Small-scale

0.479

High

1053874

IMB1
Importin subunit beta-1

1

4

Small-scale

0.479

High

1055687

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

10

High-throughput

0.479

High

1064647

NEW1
[NU+] prion formation protein 1

1

3

Small-scale

0.479

High

1064652

SAS10
Something about silencing protein 10

1

1

Small-scale

0.479

High

917534

SLD3
DNA replication regulator SLD3

1

0

Small-scale

0.460

High

1064103

SLD7
Mitochondrial morphogenesis protein SLD7

1

0

Small-scale

0.460

High

636614

PSA7
Probable proteasome subunit alpha type-7

1

0

Small-scale

0.458

High

708407

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

753048

SPC29
Spindle pole component 29

1

0

Small-scale

0.458

High

780991

SPC42
Spindle pole body component SPC42

1

0

Small-scale

0.458

High

803706

RPN1
26S proteasome regulatory subunit RPN1

1

0

Small-scale

0.458

High

805646

LSM12
Protein LSM12

1

0

Small-scale

0.458

High

809431

STM1
Suppressor protein STM1

1

0

Small-scale

0.458

High

822024

PSA4
Proteasome subunit alpha type-4

1

0

Small-scale

0.458

High

835095

HAC1
Transcriptional activator HAC1

1

0

Small-scale

0.458

High

849953

BLM10
Proteasome activator BLM10

1

0

Small-scale

0.458

High

864138

LSM1
LSM1-LSM7 complex subunit LSM1

1

0

Small-scale

0.458

High

919445

PBP1
PAB1-binding protein 1

1

0

Small-scale

0.458

High

1042832

RPN4
Protein RPN4

1

0

Small-scale

0.458

High

1044804

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1059244

PBP4
Protein PBP4

1

0

Small-scale

0.458

High

1064650

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

1064663

HAA1
Transcriptional activator HAA1

1

0

Small-scale

0.458

High

416162

SYTC
Threonine--tRNA ligase, cytoplasmic

1

1

Small-scale

0.457

High

446253

PHSG
Glycogen phosphorylase

1

1

Small-scale

0.457

High

601144

RL8A
Large ribosomal subunit protein eL8A

1

1

Small-scale

0.457

High

737057

CDC3
Cell division control protein 3

1

2

Small-scale

0.457

High

737123

CDC11
Cell division control protein 11

1

3

Small-scale

0.457

High

737346

CDC12
Cell division control protein 12

1

2

Small-scale

0.457

High

744521

HBS1
Elongation factor 1 alpha-like protein

1

1

Small-scale

0.457

High

745109

AFG2
ATPase family gene 2 protein

1

1

Small-scale

0.457

High

746759

KPR1
Ribose-phosphate pyrophosphokinase 1

1

1

Small-scale

0.457

High

789796

ADCS
Aminodeoxychorismate synthase

1

1

Small-scale

0.457

High

803254

YLF2
Obg-like ATPase homolog

1

1

Small-scale

0.457

High

803281

OTU2
OTU domain-containing protein 2

1

1

Small-scale

0.457

High

828281

SYA
Alanine--tRNA ligase, mitochondrial

1

2

Small-scale

0.457

High

917700

LSG1
Large subunit GTPase 1

1

2

Small-scale

0.457

High

1040257

GDE1
Glycerophosphocholine phosphodiesterase GDE1

1

1

Small-scale

0.457

High

1046504

TAP42
Type 2A phosphatase-associated protein 42

1

2

Small-scale

0.457

High

1046816

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

Small-scale

0.457

High

1059802

SHS1
Seventh homolog of septin 1

1

5

Small-scale

0.457

High

1062784

BRX1
Ribosome biogenesis protein BRX1

1

3

Small-scale

0.457

High

1064651

CHS5
Chitin biosynthesis protein CHS5

1

1

Small-scale

0.457

High

1064657

DBP10
ATP-dependent RNA helicase DBP10

1

4

Small-scale

0.457

High

393464

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

525399

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

527892

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

676429

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

744354

CHD1
Chromo domain-containing protein 1

1

6

High-throughput

0.445

High

804523

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

863994

JJJ2
J protein JJJ2

1

2

High-throughput

0.445

High

922657

HST2
NAD-dependent protein deacetylase HST2

1

5

Small-scale

0.445

High

1044491

RUVB1
RuvB-like protein 1

1

12

High-throughput

0.445

High

1064660

RUVB2
RuvB-like protein 2

1

12

High-throughput

0.445

High

386895

TBB
Tubulin beta chain

1

2

Small-scale

0.437

High

445375

CDC31
Cell division control protein 31

1

1

Small-scale

0.437

High

504453

RL31A
Large ribosomal subunit protein eL31A

1

1

Small-scale

0.437

High

554058

TCPA
T-complex protein 1 subunit alpha

1

2

Small-scale

0.437

High

633582

SAR1
Small COPII coat GTPase SAR1

1

1

Small-scale

0.437

High

686907

BUB2
Mitotic check point protein BUB2

1

2

Small-scale

0.437

High

737783

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

Small-scale

0.437

High

743361

FIMB
Fimbrin

1

1

Small-scale

0.437

High

755189

GCN1
eIF-2-alpha kinase activator GCN1

1

2

Small-scale

0.437

High

757675

IF4B
Eukaryotic translation initiation factor 4B

1

1

Small-scale

0.437

High

796190

OLA1
Obg-like ATPase 1

1

1

Small-scale

0.437

High

811057

TCPD
T-complex protein 1 subunit delta

1

3

Small-scale

0.437

High

836033

COPB
Coatomer subunit beta

1

1

Small-scale

0.437

High

836114

COPB2
Coatomer subunit beta'

1

4

Small-scale

0.437

High

865095

TCPQ
T-complex protein 1 subunit theta

1

2

Small-scale

0.437

High

922130

COPA
Coatomer subunit alpha

1

4

Small-scale

0.437

High

925484

EF3B
Elongation factor 3B

1

3

Small-scale

0.437

High

1046071

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.437

High

1046742

SEC13
Protein transport protein SEC13

1

5

Small-scale

0.437

High

864341

NET1
Nucleolar protein NET1

1

0

High-throughput

0.426

High

921174

H1
Histone H1

1

0

High-throughput

0.426

High

671728

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.407

High

752832

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

763506

MDJ1
DnaJ homolog 1, mitochondrial

1

2

High-throughput

0.407

High

779590

LHS1
Heat shock protein 70 homolog LHS1

1

7

High-throughput

0.407

High

823659

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.407

High

1056440

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

1

High-throughput

0.407

High

823110

ATG3
Autophagy-related protein 3

2

0

Small-scale

0.328

High

358360

ADH1
Alcohol dehydrogenase 1

2

0

High-throughput

0.307

High

150387

YP089
Dilute domain-containing protein YPR089W

1

0

Small-scale

0.261

Low

454530

PIF1
ATP-dependent DNA helicase PIF1

1

0

Small-scale

0.261

Low

534198

PCKA
Phosphoenolpyruvate carboxykinase

1

0

Small-scale

0.261

Low

575560

NMT
Glycylpeptide N-tetradecanoyltransferase

1

0

Small-scale

0.261

Low

607794

HXKG
Glucokinase-1

1

0

Small-scale

0.261

Low

613745

MET16
Phosphoadenosine phosphosulfate reductase

1

0

Small-scale

0.261

Low

733601

P5CR
Pyrroline-5-carboxylate reductase

1

0

Small-scale

0.261

Low

737150

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

1

0

Small-scale

0.261

Low

753269

MFT1
THO complex subunit MFT1

1

0

Small-scale

0.261

Low

757728

EDE1
EH domain-containing and endocytosis protein 1

1

0

Small-scale

0.261

Low

793065

PDX3
Pyridoxamine 5'-phosphate oxidase

1

0

Small-scale

0.261

Low

797294

YSW1
Spore-specific protein YSW1

1

0

Small-scale

0.261

Low

820892

SIP5
Protein SIP5

1

0

Small-scale

0.261

Low

843284

KRI1
Protein KRI1

1

0

Small-scale

0.261

Low

917596

CUE3
RQC trigger complex subunit CUE3

1

0

Small-scale

0.261

Low

918157

EFM5
Protein-lysine N-methyltransferase EFM5

1

0

Small-scale

0.261

Low

919071

VOA1
V0 assembly protein 1

1

0

Small-scale

0.261

Low

924393

BNI5
Bud neck protein 5

1

0

Small-scale

0.261

Low

924928

APP1
Phosphatidate phosphatase APP1

1

0

Small-scale

0.261

Low

1046449

YM54
Uncharacterized protein YMR196W

1

0

Small-scale

0.261

Low

1051701

DON1
Donuts protein 1

1

0

Small-scale

0.261

Low

1052205

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

Small-scale

0.261

Low

1053854

YL345
Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W [Includes: 6-phosphofructo-2-kinase

1

0

Small-scale

0.261

Low

1053910

YL257
Uncharacterized protein YLR257W

1

0

Small-scale

0.261

Low

1057091

MDM36
Mitochondrial distribution and morphology protein 36

1

0

Small-scale

0.261

Low

1064621

AB140
tRNA(Thr)

1

0

Small-scale

0.261

Low

1064645

MSC6
Meiotic sister-chromatid recombination protein 6, mitochondrial

1

0

Small-scale

0.261

Low

1064646

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

Small-scale

0.261

Low

1064653

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

Small-scale

0.261

Low

1064661

ATG11
Autophagy-related protein 11

1

0

Small-scale

0.261

Low

449192

CALM
Calmodulin

1

0

Small-scale

0.249

Low

536056

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

0

Small-scale

0.249

Low

536182

ARF1
ADP-ribosylation factor 1

1

0

Small-scale

0.249

Low

661699

MPCP
Mitochondrial phosphate carrier protein

1

0

Small-scale

0.249

Low

732202

COPG
Coatomer subunit gamma

1

0

Small-scale

0.249

Low

734628

NUD1
Protein NUD1

1

0

Small-scale

0.249

Low

747084

SKG6
Protein SKG6

1

0

Small-scale

0.249

Low

801117

FKS1
1,3-beta-glucan synthase component FKS1

1

0

Small-scale

0.249

Low

817098

RPN3
26S proteasome regulatory subunit RPN3

1

0

Small-scale

0.249

Low

825256

SEC24
Protein transport protein SEC24

1

0

Small-scale

0.249

Low

825684

COPE
Coatomer subunit epsilon

1

0

Small-scale

0.249

Low

858139

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

Small-scale

0.249

Low

865486

BFA1
Mitotic check point protein BFA1

1

0

Small-scale

0.249

Low

874569

RS12
Small ribosomal subunit protein eS12

1

0

Small-scale

0.249

Low

1043603

CLU
Clustered mitochondria protein 1

1

0

Small-scale

0.249

Low

1062206

MDM38
Mitochondrial distribution and morphology protein 38

1

0

Small-scale

0.249

Low

1064654

PST1
Cell wall mannoprotein PST1

1

0

High-throughput

0.249

Low

1064655

BBP1
Spindle pole component BBP1

1

0

Small-scale

0.249

Low

1018188

YD271
Putative uncharacterized protein YDR271C

1

0

High-throughput

0.238

Low

394969

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

453833

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

1046612

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025