HitPredict

Interactor 1: RAD23 (P32628)
UV excision repair protein RAD23
Gene: RAD23

Interactor 2: RPN1 (P38764)
26S proteasome regulatory subunit RPN1 (HMG-CoA reductase degradation protein 2) (Proteasome non-ATPase subunit 1)
Gene: RPN1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.989

Property	Details
Experiments	12200120, 11595789, 26912900, 12198498, 18511945, 10688190, 17082762, 18757749, 34364874, 33617881, 21627799, 22318722, 15121879, 16554755, 27396824, 37968396, 20059542, 16401726, 16429126
Identification Methods	cross-linking study, two hybrid, pull down, isothermal titration calorimetry, filter binding, nuclear magnetic resonance, affinity chromatography technology, far western blotting, x-ray crystallography, two hybrid array and 1 others more... tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PC_rep~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0030674 - protein-macromolecule adaptor activity GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 398 Sc			1 993
+	Rn
		1194066 RD23B_RAT (2-398): 7.82e-92: 284: 27.50		PSMD2_RAT (2-989): 0: 1013: 34.70
+	Hs
		931656 RD23B_HUMAN (2-398): 5.12e-90: 279: 27.50		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		931508 RD23A_HUMAN (2-398): 3.39e-87: 270: 28.09		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		1098165 UBQL1_HUMAN (1-373): 1.05e-58: 202: 12.53		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		1098159 UBQL2_HUMAN (1-373): 8.72e-55: 192: 12.65		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	At
		1284089 RD23C_ARATH (2-398): 8.24e-89: 276: 25.62		PSD2A_ARATH (38-992): 0: 925: 33.61
+	Sc
		803608 DSK2_YEAST (2-282): 4.41e-39: 145: 17.09		RPN1_YEAST (1-993): 0: 1053: 100.00
+	Hs
		1098150 UBQL4_HUMAN (2-373): 1.17e-52: 186: 13.76		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Hs
		987007 RS27A_HUMAN (2-89): 1.27e-38: 137: 22.73		PSMD2_HUMAN (2-989): 0: 1010: 34.61
+	Sp
		268138 RHP23_SCHPO (2-398): 4.2e-81: 255: 33.25		RPN1_SCHPO (5-988): 0: 871: 37.71
+	Hs
		931703 RD23B_HUMAN (2-398): 5.12e-90: 279: 27.50		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Rn
		312922 RD23B_RAT (2-398): 7.82e-92: 284: 27.50		PSMD1_RAT (52-925): 0: 699: 13.20
+	Hs
		931585 RD23A_HUMAN (2-398): 3.39e-87: 270: 28.09		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Dm
		1470298 Q9VCD5_DROME (2-398): 1.56e-52: 178: 20.55		Q9VW54_DROME (1-989): 0: 738: 33.30
+	Hs
		1404607 UBQL1_HUMAN (1-373): 1.05e-58: 202: 12.53		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Dm
		1487629 Q9VWD9_DROME (2-374): 1.82e-47: 171: 13.38		Q9VW54_DROME (1-989): 0: 738: 33.30
+	Hs
		1404601 UBQL2_HUMAN (1-373): 8.72e-55: 192: 12.65		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Hs
		1404590 UBQL4_HUMAN (2-373): 1.17e-52: 186: 13.76		PSMD1_HUMAN (52-925): 0: 709: 13.42
+	Sc
		740125 RAD23_YEAST (1-398): 8.43e-101: 306: 100.00		RPN2_YEAST (52-815): 2.97e-177: 542: 15.54
+	Dm
		1464103 Q9VWD9_DROME (2-374): 1.82e-47: 171: 13.38		PSMD1_DROME (52-925): 0: 664: 13.63