HitPredict

Interactor 1: SMC1 (P32908)
Structural maintenance of chromosomes protein 1 (DA-box protein SMC1)
Gene: SMC1

Interactor 2: PDS5 (Q04264)
Sister chromatid cohesion protein PDS5 (Precocious dissociation of sisters protein 5)
Gene: PDS5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	17660750, 34259632, 21441928
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006302 - double-strand break repair GO:0007064 - mitotic sister chromatid cohesion GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1225 Sc			1 1277
+	Mm
		1196835 SMC1A_MOUSE (1-1225): 1.36e-94: 332: 27.16		PDS5B_MOUSE (3-1272): 0: 1249: 18.49
+	Hs
		1130199 SMC1A_HUMAN (1-1225): 1.36e-94: 332: 27.16		PDS5B_HUMAN (3-1272): 0: 1244: 18.31
+	Hs
		1130059 SMC1A_HUMAN (1-1225): 1.36e-94: 332: 27.16		PDS5A_HUMAN (4-1252): 0: 1216: 18.06
+	Mm
		98417 SMC1A_MOUSE (1-1225): 1.36e-94: 332: 27.16		E9QPI5_MOUSE (4-1265): 0: 1209: 17.95
+	Mm
		1230034 SMC1A_MOUSE (1-1225): 1.36e-94: 332: 27.16		PDS5A_MOUSE (4-1265): 0: 1192: 17.95
+	Hs
		1449532 SMC3_HUMAN (3-1222): 8.01e-77: 279: 16.89		PDS5B_HUMAN (3-1272): 0: 1244: 18.31
+	Sc
		864370 SMC3_YEAST (3-1221): 6.04e-67: 249: 15.88		PDS5_YEAST (1-1277): 0: 1271: 100.00
+	Xl
		313476 SMC1A_XENLA (1-1225): 2.23e-88: 314: 26.92		PD5BA_XENLA (2-1271): 0: 1203: 18.31
+	Xl
		313477 SMC1A_XENLA (1-1225): 2.23e-88: 314: 26.92		PD5AB_XENLA (5-1251): 0: 1202: 17.07
+	Xl
		313478 SMC1A_XENLA (1-1225): 2.23e-88: 314: 26.92		PD5AA_XENLA (3-1251): 0: 1200: 17.11
+	Hs
		1177664 SMC3_HUMAN (3-1222): 8.01e-77: 279: 16.89		PDS5A_HUMAN (4-1252): 0: 1216: 18.06
+	Xl
		313488 SMC3_XENLA (3-1222): 1.25e-76: 279: 17.07		PD5BB_XENLA (2-1271): 0: 1215: 18.38
+	Mm
		98418 SMC3_MOUSE (3-1222): 5.25e-77: 280: 16.89		E9QPI5_MOUSE (4-1265): 0: 1209: 17.95
+	Xl
		313486 SMC3_XENLA (3-1222): 1.25e-76: 279: 17.07		PD5BA_XENLA (2-1271): 0: 1203: 18.31
+	Xl
		1193295 Q8AW91_XENLA (3-1222): 5.56e-76: 277: 16.96		PD5BA_XENLA (2-1271): 0: 1203: 18.31
+	Xl
		1195181 Q8AW91_XENLA (3-1222): 5.56e-76: 277: 16.96		PD5AB_XENLA (5-1251): 0: 1202: 17.07
+	Xl
		313487 SMC3_XENLA (3-1222): 1.25e-76: 279: 17.07		PD5AA_XENLA (3-1251): 0: 1200: 17.11
+	Sp
		314036 SMC1_SCHPO (1-1225): 4.68e-77: 280: 33.09		PDS5_SCHPO (8-1196): 0: 978: 23.44
+	Sp
		205974 SMC3_SCHPO (3-1221): 6.51e-73: 267: 16.29		PDS5_SCHPO (8-1196): 0: 978: 23.44
+	Hs
		72294 SMC1A_HUMAN (1-1225): 1.36e-94: 332: 27.16		A9IYQ1_HUMAN (1077-1272): 5.59e-45: 166: 16.59