HitPredict

Interactor 1: ARPC1 (P38328)
Actin-related protein 2/3 complex subunit 1 (Arp2/3 complex 41 kDa subunit) (p41-ARC)
Gene: ARC40

Interactor 2: CORO (Q06440)
Coronin-like protein
Gene: CRN1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	16554755
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DUF1899~WD40, WD40~WD40, WD40~WD40_4
Common GO terms	GO:0030479 - actin cortical patch GO:0051015 - actin filament binding GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 384 Sc			1 651
+	Hs
		1163297 POC1A_HUMAN (144-384): 3.45e-45: 162: 11.93		CORO6_HUMAN (1-463): 2.99e-88: 284: 36.56
+	Hs
		678293 POC1B_HUMAN (136-384): 1.51e-45: 164: 10.22		COR1A_HUMAN (1-458): 4.66e-86: 278: 37.07
+	Hs
		678289 POC1A_HUMAN (144-384): 3.45e-45: 162: 11.93		COR1A_HUMAN (1-458): 4.66e-86: 278: 37.07
+	Hs
		1240442 POC1B_HUMAN (136-384): 1.51e-45: 164: 10.22		POC1A_HUMAN (124-486): 1.87e-60: 209: 12.30
+	Hs
		1313645 KTNB1_HUMAN (151-384): 5.42e-42: 157: 14.77		KTNB1_HUMAN (4-209): 2.6e-49: 184: 22.71
+	Hs
		903418 FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89		WDR5_HUMAN (262-452): 3.45e-23: 102: 5.70
+	Hs
		878165 SEC13_HUMAN (31-313): 1.31e-64: 210: 20.89		WDR5_HUMAN (262-452): 3.45e-23: 102: 5.70
+	Dm
		1358845 WDS_DROME (102-384): 3.1e-63: 208: 14.39		WDS_DROME (262-452): 1.89e-22: 101: 5.70
+	Hs
		903349 WDR5_HUMAN (182-383): 7.51e-36: 135: 12.75		WDR5B_HUMAN (216-438): 2.83e-31: 126: 9.74
+	Hs
		903551 NLE1_HUMAN (182-382): 2.63e-35: 136: 11.33		WDR5_HUMAN (262-452): 3.45e-23: 102: 5.70
+	Hs
		903077 WDR5_HUMAN (182-383): 7.51e-36: 135: 12.75		WDR5_HUMAN (262-452): 3.45e-23: 102: 5.70
+	Hs
		1309163 TBL1Y_HUMAN (52-384): 8.43e-20: 92.7: 12.77		TBL1R_HUMAN (70-310): 1.34e-25: 113: 19.42
+	Hs
		1346954 NLE1_HUMAN (182-382): 2.63e-35: 136: 11.33		NLE1_HUMAN (302-558): 9.47e-11: 66.7: 7.25
+	Hs
		903428 WDR5_HUMAN (182-383): 7.51e-36: 135: 12.75		SNR40_HUMAN (314-524): 2.37e-09: 61.7: 11.27
+	Hs
		282871 CIAO1_HUMAN (7-142): 6.72e-21: 94.4: 14.56		WDR5_HUMAN (262-452): 3.45e-23: 102: 5.70
+	Hs
		903109 RACK1_HUMAN (1-141): 2.31e-20: 92.5: 12.93		WDR5_HUMAN (262-452): 3.45e-23: 102: 5.70
+	Hs
		245630 TBL1Y_HUMAN (52-384): 8.43e-20: 92.7: 12.77		TBL1X_HUMAN (74-217): 9.27e-13: 73.2: 35.17