Protein: SSH1
Sec sixty-one protein homolog (Ssh1 complex subunit SSH1) (Ssh1 complex subunit alpha)

Gene: SSH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 71
UniProt ID: P38353

Gene Ontology (top 5):
GO:0005048 - signal sequence binding
GO:0005783 - endoplasmic reticulum
GO:0005784 - Sec61 translocon complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006614 - SRP-dependent cotranslational protein targeting to membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

763148

SC61G
Protein transport protein SSS1

3

2

Small-scale

0.849

High

798656

SC6B2
Protein transport protein SBH2

3

3

Small-scale

0.821

High

798655

SC6B1
Protein transport protein SBH1

2

3

Small-scale

0.744

High

796903

PHO88
SRP-independent targeting protein 3

3

1

High-throughput

0.669

High

754391

SEC66
Translocation protein SEC66

1

1

Small-scale

0.647

High

798661

ERV29
ER-derived vesicles protein ERV29

2

2

High-throughput

0.632

High

577117

SEC63
Protein translocation protein SEC63

2

6

High-throughput

0.614

High

797375

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

2

3

High-throughput

0.614

High

798646

ELO3
Fatty acid elongase 3

2

3

High-throughput

0.614

High

754680

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

2

2

High-throughput

0.601

High

748369

SC61A
Protein transport protein SEC61

1

2

High-throughput

0.590

High

798638

SSH1
Sec sixty-one protein homolog

1

2

High-throughput

0.590

High

798653

STE24
CAAX prenyl protease 1

2

0

High-throughput

0.588

High

672795

ELO2
Fatty acid elongase 2

1

3

High-throughput

0.541

High

776352

YET1
Endoplasmic reticulum transmembrane protein 1

1

3

High-throughput

0.541

High

780443

SRPB
Signal recognition particle receptor subunit beta

1

3

High-throughput

0.541

High

798639

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

1

High-throughput

0.541

High

798648

SNL1
HSP70 co-chaperone SNL1

1

1

High-throughput

0.541

High

798657

ERG25
C-4 methylsterol oxidase ERG25

1

1

High-throughput

0.541

High

798662

TMEDA
Endoplasmic reticulum vesicle protein 25

1

3

High-throughput

0.541

High

798663

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

1

High-throughput

0.541

High

798668

GSF2
Glucose-signaling factor 2

1

1

High-throughput

0.541

High

798670

ERP1
Protein ERP1

1

3

High-throughput

0.541

High

798671

ORM2
Protein ORM2

1

1

High-throughput

0.541

High

798679

ERP4
Protein ERP4

1

2

High-throughput

0.541

High

439520

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.518

High

528581

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.518

High

703811

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.518

High

798640

YHU0
UPF0641 membrane protein YHR140W

1

0

High-throughput

0.518

High

798642

SRP14
Signal recognition particle subunit SRP14

1

0

High-throughput

0.518

High

798651

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.518

High

798652

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

0

High-throughput

0.518

High

798659

MST27
Multicopy suppressor of SEC21 protein 27

1

0

High-throughput

0.518

High

798664

SCS7
Ceramide very long chain fatty acid hydroxylase SCS7

1

0

High-throughput

0.518

High

798665

GOT1
Protein transport protein GOT1

1

0

High-throughput

0.518

High

798678

YOP1
Protein YOP1

1

0

High-throughput

0.518

High

366019

INV2
Invertase 2

1

1

Small-scale

0.494

High

798674

VHS3
Phosphopantothenoylcysteine decarboxylase subunit VHS3

1

2

High-throughput

0.494

High

597124

BIP
Endoplasmic reticulum chaperone BiP

1

3

Small-scale

0.481

High

798676

NPC1
NPC intracellular sterol transporter 1-related protein 1

1

2

Small-scale

0.481

High

678005

CWH43
Protein CWH43

1

1

High-throughput

0.479

High

754616

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

2

High-throughput

0.479

High

798645

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

2

High-throughput

0.479

High

798654

HLJ1
Protein HLJ1

1

2

High-throughput

0.479

High

798658

ERV14
ER-derived vesicles protein ERV14

1

1

High-throughput

0.479

High

798680

ENV10
SRP-independent targeting protein 2

1

3

High-throughput

0.479

High

798647

COPE
Coatomer subunit epsilon

1

1

High-throughput

0.470

High

554341

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.458

High

798643

GAA1
GPI transamidase component GAA1

1

0

High-throughput

0.458

High

609273

CPT1
Cholinephosphotransferase 1

1

0

High-throughput

0.438

High

798669

DFG5
Mannan endo-1,6-alpha-mannosidase DFG5

1

0

High-throughput

0.438

High

510448

HSP77
Import motor subunit, mitochondrial

1

3

High-throughput

0.437

High

670641

SIS1
Protein SIS1

1

2

High-throughput

0.437

High

794958

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

798644

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

798650

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

798673

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.437

High

746001

VATL2
V-type proton ATPase subunit c'

1

0

High-throughput

0.282

High

798666

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

0

High-throughput

0.282

High

518277

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.269

Low

399828

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

0

High-throughput

0.249

Low

661507

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

677369

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

798641

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

798649

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

798660

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

798667

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

798677

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.249

Low

798672

YL311
Putative uncharacterized membrane protein YLR311C

1

0

High-throughput

0.238

Low

798675

CWC2
Pre-mRNA-splicing factor CWC2

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025