HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26831064
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 2725
+	Hs
		597990 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		261214 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Hs
		749416 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		ACTN3_HUMAN (23-388): 4.53e-120: 406: 27.63
+	Hs
		749382 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		749718 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TITIN_HUMAN (1554-2636): 3.13e-09: 65.5: 10.78
+	Hs
		598234 MCPH1_HUMAN (1150-1857): 1.33e-95: 331: 14.19		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		62677 TRI64_HUMAN (12-413): 3.39e-71: 248: 11.55		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		598309 TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		521464 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		62673 TRI64_HUMAN (12-413): 3.39e-71: 248: 11.55		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		211495 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		363295 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83