Protein: C2TA
MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1)

Gene: C2TA, CIITA
Organism: Homo sapiens
Interactions: 63
UniProt ID: P33076

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

533888

IRF1
Interferon regulatory factor 1

11

7

Small-scale

0.751

High

749459

RFX5
DNA-binding protein RFX5

6

1

Small-scale

0.727

High

703455

MK01
Mitogen-activated protein kinase 1

1

3

Small-scale

0.724

High

571561

IRF2
Interferon regulatory factor 2

6

7

Small-scale

0.721

High

749486

HDAC2
Histone deacetylase 2

4

2

Small-scale

0.694

High

749458

STAT1
Signal transducer and activator of transcription 1-alpha/beta

6

0

Small-scale

0.690

High

648330

USF1
Upstream stimulatory factor 1

4

5

Small-scale

0.683

High

749465

PRS8
26S proteasome regulatory subunit 8

3

4

Small-scale

0.664

High

749488

KAT2B
Histone acetyltransferase KAT2B

2

4

Small-scale

0.653

High

749460

GSK3B
Glycogen synthase kinase-3 beta

1

2

Small-scale

0.647

High

749462

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

3

3

Small-scale

0.646

High

158405

RFXK
DNA-binding protein RFXANK

2

4

Small-scale

0.624

High

380264

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

3

Small-scale

0.618

High

691644

MK03
Mitogen-activated protein kinase 3

1

3

Small-scale

0.618

High

443220

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.614

High

289120

PRDM1
PR domain zinc finger protein 1

2

3

Small-scale

0.601

High

749487

CBP
CREB-binding protein

2

5

Small-scale

0.595

High

749481

ZXDC
Zinc finger protein ZXDC

2

2

Small-scale

0.592

High

749464

RAB4B
Ras-related protein Rab-4B

1

0

Small-scale

0.586

High

609907

SPI1
Transcription factor PU.1

2

2

Small-scale

0.584

High

749469

IRF8
Interferon regulatory factor 8

2

7

Small-scale

0.584

High

749471

EP300
Histone acetyltransferase p300

2

4

Small-scale

0.584

High

749477

IRF4
Interferon regulatory factor 4

2

7

Small-scale

0.584

High

172507

XPO1
Exportin-1

2

0

Small-scale

0.569

High

749473

HDAC1
Histone deacetylase 1

1

2

Small-scale

0.561

High

749478

NCOA1
Nuclear receptor coactivator 1

1

1

Small-scale

0.561

High

749484

FBX11
F-box only protein 11

2

0

Small-scale

0.559

High

749467

ZXDA
Zinc finger X-linked protein ZXDA

1

2

Small-scale

0.526

High

593032

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

Small-scale

0.515

High

749489

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

3

Small-scale

0.515

High

749468

TF2B
Transcription initiation factor IIB

1

0

Small-scale

0.480

High

749479

TAF9
Transcription initiation factor TFIID subunit 9

1

0

Small-scale

0.480

High

210873

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

Small-scale

0.479

High

371297

MYC
Myc proto-oncogene protein

1

5

Small-scale

0.479

High

464837

SP1
Transcription factor Sp1

1

2

Small-scale

0.479

High

587423

TFE2
Transcription factor E2-alpha

1

1

Small-scale

0.479

High

610242

PRS6A
26S proteasome regulatory subunit 6A

1

7

Small-scale

0.479

High

617080

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

2

Small-scale

0.479

High

749455

HS71L
Heat shock 70 kDa protein 1-like

1

10

Small-scale

0.479

High

749456

PRS7
26S proteasome regulatory subunit 7

1

3

Small-scale

0.479

High

749457

PPARG
Peroxisome proliferator-activated receptor gamma

1

7

Small-scale

0.479

High

749461

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

3

Small-scale

0.479

High

749463

HDAC4
Histone deacetylase 4

1

4

Small-scale

0.479

High

749466

SKP1
S-phase kinase-associated protein 1

1

3

Small-scale

0.479

High

749470

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

749472

TRI26
Tripartite motif-containing protein 26

1

17

Small-scale

0.479

High

749474

CUL1
Cullin-1

1

12

Small-scale

0.479

High

749475

CUL3
Cullin-3

1

12

Small-scale

0.479

High

749476

MYPC2
Myosin-binding protein C, fast-type

1

1

Small-scale

0.479

High

749480

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

749483

ATD3B
ATPase family AAA domain-containing protein 3B

1

9

Small-scale

0.479

High

749485

TRI22
E3 ubiquitin-protein ligase TRIM22

1

14

Small-scale

0.479

High

749490

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

1

Small-scale

0.479

High

749491

EP400
E1A-binding protein p400

1

4

Small-scale

0.479

High

749492

MMS19
MMS19 nucleotide excision repair protein homolog

1

2

Small-scale

0.479

High

749493

ATD3A
ATPase family AAA domain-containing protein 3A

1

7

Small-scale

0.479

High

749494

HDAC5
Histone deacetylase 5

1

4

Small-scale

0.479

High

749495

NINL
Ninein-like protein

1

5

High-throughput

0.479

High

274286

SIN3B
Paired amphipathic helix protein Sin3b

1

0

Small-scale

0.458

High

407043

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

Small-scale

0.458

High

628714

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

749482

ZN672
Zinc finger protein 672

1

0

Small-scale

0.458

High

163542

TPP1
Tripeptidyl-peptidase 1

1

1

Small-scale

0.437

High


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Last updated: 11Aug2025