HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	25531315, 23624935
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 746
+	Mm
		822738 BRCA1_MOUSE (1-1858): 0: 1394: 55.69		EZH2_MOUSE (1-746): 0: 860: 98.39
+	Hs
		331732 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		165641 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71
+	Hs
		584972 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080310 TRIM4_HUMAN (15-377): 1.5e-62: 225: 11.52		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		585025 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		EZH1_HUMAN (15-745): 0: 745: 63.48
+	Hs
		203749 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Hs
		975295 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		1317576 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Hs
		165624 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71