HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: FACD2 (Q9BXW9)
Fanconi anemia group D2 protein (Protein FACD2)
Gene: FANCD2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

Property	Details
Experiments	14499622, 31180492, 11239454, 25652403, 29656893, 12887909
Identification Methods	two hybrid, affinity chromatography technology, proximity labelling technology, enzymatic study, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016604 - nuclear body GO:1990391 - DNA repair complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 1451
+	Hs
		1266881 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		FACD2_HUMAN (1-1441): 0: 2030: 100.00
+	Mm
		1112450 Q3UCL2_MOUSE (14-409): 2.99e-67: 237: 13.40		FACD2_MOUSE (1-1439): 0: 1973: 74.76
+	Hs
		1305945 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		FACD2_HUMAN (1-1441): 0: 2030: 100.00