Protein: ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)

Gene: ODB2, DBT
Organism: Homo sapiens
Interactions: 193
UniProt ID: P11182

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol
GO:0009083 - branched-chain amino acid catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

452591

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

3

12

High-throughput

0.861

High

505935

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

2

8

High-throughput

0.811

High

506058

ACAD9
Complex I assembly factor ACAD9, mitochondrial

4

3

High-throughput

0.699

High

506023

RRFM
Ribosome-recycling factor, mitochondrial

4

3

High-throughput

0.694

High

506006

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

5

0

High-throughput

0.688

High

215960

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

3

1

High-throughput

0.667

High

505937

ECHM
Enoyl-CoA hydratase, mitochondrial

3

6

High-throughput

0.667

High

505988

MRM1
rRNA methyltransferase 1, mitochondrial

3

2

High-throughput

0.667

High

506073

HDAC6
Histone deacetylase 6

3

3

Small-scale

0.667

High

505931

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

2

High-throughput

0.662

High

506012

GRPE2
GrpE protein homolog 2, mitochondrial

3

0

High-throughput

0.638

High

506084

LIPT
Lipoyl amidotransferase LIPT1, mitochondrial

3

0

High-throughput

0.638

High

505930

RALB
Ras-related protein Ral-B

2

6

High-throughput

0.628

High

505961

RT11
Small ribosomal subunit protein uS11m

2

3

High-throughput

0.628

High

506008

PTGR3
Prostaglandin reductase 3

2

4

High-throughput

0.628

High

506040

TR61B
tRNA

2

2

High-throughput

0.628

High

506076

NOCT
Nocturnin

2

1

High-throughput

0.628

High

325009

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

13

High-throughput

0.618

High

440315

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

11

High-throughput

0.618

High

269972

RF1M
Peptide chain release factor 1, mitochondrial

2

10

High-throughput

0.611

High

506041

HINT2
Adenosine 5'-monophosphoramidase HINT2

2

3

High-throughput

0.611

High

506048

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

2

4

High-throughput

0.611

High

506028

FAH2A
Fumarylacetoacetate hydrolase domain-containing protein 2A

3

3

High-throughput

0.609

High

505980

CDO1
Cysteine dioxygenase type 1

2

0

High-throughput

0.602

High

505983

THEM4
Acyl-coenzyme A thioesterase THEM4

2

0

High-throughput

0.602

High

506011

PPTC7
Protein phosphatase PTC7 homolog

2

0

High-throughput

0.602

High

506085

CAH5B
Carbonic anhydrase 5B, mitochondrial

2

0

High-throughput

0.595

High

505934

TNR1B
Tumor necrosis factor receptor superfamily member 1B

2

0

High-throughput

0.585

High

262688

CISY
Citrate synthase, mitochondrial

2

2

High-throughput

0.584

High

505950

PPT1
Palmitoyl-protein thioesterase 1

2

1

Small-scale

0.584

High

506013

DCA11
DDB1- and CUL4-associated factor 11

2

2

High-throughput

0.574

High

505974

ICT1
Large ribosomal subunit protein mL62

2

2

High-throughput

0.571

High

135349

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

High-throughput

0.536

High

456203

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

3

High-throughput

0.536

High

505944

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

3

High-throughput

0.536

High

505960

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

1

High-throughput

0.536

High

505970

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

6

High-throughput

0.536

High

505991

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

3

High-throughput

0.536

High

506003

HOGA1
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

1

1

High-throughput

0.536

High

506004

ECHD2
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial

1

6

High-throughput

0.536

High

506005

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

1

High-throughput

0.536

High

506026

MMAB
Corrinoid adenosyltransferase MMAB

1

1

High-throughput

0.536

High

506033

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.536

High

506039

MECR
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

4

High-throughput

0.536

High

506060

AGO3
Protein argonaute-3

1

4

High-throughput

0.536

High

506061

AGO4
Protein argonaute-4

1

4

High-throughput

0.536

High

506062

E41L5
Band 4.1-like protein 5

1

3

High-throughput

0.536

High

506071

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

High-throughput

0.536

High

506079

HECD1
E3 ubiquitin-protein ligase HECTD1

2

7

High-throughput

0.533

High

505965

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

5

High-throughput

0.515

High

506015

DDX1
ATP-dependent RNA helicase DDX1

1

1

High-throughput

0.515

High

506089

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

3

High-throughput

0.515

High

495672

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.513

High

505940

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.513

High

505953

NUDT6
Nucleoside diphosphate-linked moiety X motif 6

1

0

High-throughput

0.513

High

505962

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.513

High

505981

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.513

High

506000

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.513

High

506025

RM53
Large ribosomal subunit protein mL53

1

0

High-throughput

0.513

High

506030

MCEE
Methylmalonyl-CoA epimerase, mitochondrial

1

0

High-throughput

0.513

High

506034

NPS3B
Protein NipSnap homolog 3B

1

0

High-throughput

0.513

High

506035

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.513

High

506053

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.513

High

506059

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

506065

ACO13
Acyl-coenzyme A thioesterase 13

1

0

High-throughput

0.513

High

506077

PRDM4
PR domain zinc finger protein 4

1

0

High-throughput

0.513

High

506087

MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

1

0

High-throughput

0.513

High

174580

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.501

High

434456

FUMH
Fumarate hydratase, mitochondrial

1

0

High-throughput

0.493

High

505949

GATM
Glycine amidinotransferase, mitochondrial

1

0

High-throughput

0.493

High

506038

MTND
Acireductone dioxygenase

1

0

High-throughput

0.493

High

272980

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.489

High

505952

RBM5
RNA-binding protein 5

1

2

High-throughput

0.489

High

505990

FAH2B
Fumarylacetoacetate hydrolase domain-containing protein 2B

1

3

High-throughput

0.489

High

506002

MICU3
Calcium uptake protein 3, mitochondrial

1

2

High-throughput

0.489

High

506009

F133A
Protein FAM133A

1

1

High-throughput

0.489

High

506051

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

1

High-throughput

0.489

High

506052

RAB17
Ras-related protein Rab-17

1

8

High-throughput

0.489

High

63279

MET15
12S rRNA N4-methylcytidine

1

2

High-throughput

0.479

High

128006

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

1

High-throughput

0.479

High

148034

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

6

High-throughput

0.479

High

226358

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

264821

MPPB
Mitochondrial-processing peptidase subunit beta

1

9

High-throughput

0.479

High

294303

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

302475

CE152
Centrosomal protein of 152 kDa

1

4

High-throughput

0.479

High

325606

LATS1
Serine/threonine-protein kinase LATS1

1

4

High-throughput

0.479

High

327343

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

4

High-throughput

0.479

High

345785

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

377054

GCR
Glucocorticoid receptor

1

7

Small-scale

0.479

High

486446

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

505936

SP100
Nuclear autoantigen Sp-100

1

6

High-throughput

0.479

High

505939

MERL
Merlin

1

3

High-throughput

0.479

High

505941

MDHM
Malate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

505943

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

505945

EFTS
Elongation factor Ts, mitochondrial

1

3

High-throughput

0.479

High

505946

IF2M
Translation initiation factor IF-2, mitochondrial

1

9

High-throughput

0.479

High

505948

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.479

High

505951

RND2
Rho-related GTP-binding protein RhoN

1

14

High-throughput

0.479

High

505954

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

505956

DJB13
DnaJ homolog subfamily B member 13

1

2

High-throughput

0.479

High

505957

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

505963

RHOG
Rho-related GTP-binding protein RhoG

1

6

High-throughput

0.479

High

505964

TFAM
Transcription factor A, mitochondrial

1

3

High-throughput

0.479

High

505966

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

505967

MPPA
Mitochondrial-processing peptidase subunit alpha

1

9

High-throughput

0.479

High

505968

GRSF1
G-rich sequence factor 1

1

4

High-throughput

0.479

High

505969

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

505972

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

505973

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.479

High

505975

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

9

High-throughput

0.479

High

505976

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.479

High

505978

RHOH
Rho-related GTP-binding protein RhoH

1

11

High-throughput

0.479

High

505979

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

3

High-throughput

0.479

High

505982

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

505986

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

505987

FTM
Protein fantom

1

7

High-throughput

0.479

High

505989

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

6

High-throughput

0.479

High

505992

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

505995

RHOU
Rho-related GTP-binding protein RhoU

1

11

High-throughput

0.479

High

505996

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

9

High-throughput

0.479

High

505997

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

505998

CNTRL
Centriolin

1

10

High-throughput

0.479

High

506017

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

506019

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

506020

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

8

High-throughput

0.479

High

506021

FAKD4
FAST kinase domain-containing protein 4

1

9

High-throughput

0.479

High

506022

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

6

High-throughput

0.479

High

506024

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

506027

BICD1
Protein bicaudal D homolog 1

1

7

High-throughput

0.479

High

506031

EFGM
Elongation factor G, mitochondrial

1

8

High-throughput

0.479

High

506036

TACO1
Translational activator of cytochrome c oxidase 1

1

3

High-throughput

0.479

High

506037

CQ080
Mitochondrial nucleoid-associated protein 1

1

3

High-throughput

0.479

High

506044

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

5

Small-scale

0.479

High

506045

RT26
Small ribosomal subunit protein mS26

1

3

High-throughput

0.479

High

506046

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.479

High

506049

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

506054

IF3M
Translation initiation factor IF-3, mitochondrial

1

2

High-throughput

0.479

High

506055

MTRFR
Mitochondrial translation release factor in rescue

1

10

High-throughput

0.479

High

506056

MTG2
Mitochondrial ribosome-associated GTPase 2

1

6

High-throughput

0.479

High

506057

MET17
Ribosome assembly protein METTL17, mitochondrial

1

3

High-throughput

0.479

High

506064

BRD7
Bromodomain-containing protein 7

1

9

High-throughput

0.479

High

506067

ANLN
Anillin

1

2

High-throughput

0.479

High

506068

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

506069

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

4

High-throughput

0.479

High

506072

MRES1
Mitochondrial transcription rescue factor 1

1

3

High-throughput

0.479

High

506074

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

10

High-throughput

0.479

High

506075

HOOK1
Protein Hook homolog 1

1

5

High-throughput

0.479

High

506078

BRPF3
Bromodomain and PHD finger-containing protein 3

1

7

High-throughput

0.479

High

506080

MYO6
Unconventional myosin-VI

1

4

High-throughput

0.479

High

506082

CE164
Centrosomal protein of 164 kDa

1

7

High-throughput

0.479

High

506086

RM11
Large ribosomal subunit protein uL11m

1

3

High-throughput

0.479

High

173550

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

505958

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

505971

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

Small-scale

0.458

High

505977

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

505999

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

506016

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

506063

DLRB1
Dynein light chain roadblock-type 1

1

0

High-throughput

0.458

High

506070

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.458

High

128411

DNM1L
Dynamin-1-like protein

1

1

Small-scale

0.445

High

401312

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

414426

PRGR
Progesterone receptor

1

7

Small-scale

0.445

High

505938

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

505959

YBOX1
Y-box-binding protein 1

1

1

Small-scale

0.445

High

505984

CP135
Centrosomal protein of 135 kDa

1

9

High-throughput

0.445

High

506010

POC5
Centrosomal protein POC5

1

3

High-throughput

0.445

High

506029

CEP63
Centrosomal protein of 63 kDa

1

7

High-throughput

0.445

High

506032

CK5P2
CDK5 regulatory subunit-associated protein 2

1

9

High-throughput

0.445

High

506043

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.445

High

506090

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

5

High-throughput

0.445

High

319109

BRD1
Bromodomain-containing protein 1

1

5

High-throughput

0.437

High

441848

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.437

High

505932

TAL1
T-cell acute lymphocytic leukemia protein 1

1

2

High-throughput

0.437

High

505993

CE128
Centrosomal protein of 128 kDa

1

8

High-throughput

0.437

High

506007

NIN
Ninein

1

10

High-throughput

0.437

High

506014

PHIP
PH-interacting protein

1

5

High-throughput

0.437

High

506018

DPF3
Zinc finger protein DPF3

1

3

Small-scale

0.437

High

506042

CECR2
Chromatin remodeling regulator CECR2

1

7

High-throughput

0.437

High

506047

FOXQ1
Forkhead box protein Q1

1

3

High-throughput

0.437

High

506081

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.437

High

506083

SRRM2
Serine/arginine repetitive matrix protein 2

1

1

High-throughput

0.437

High

505933

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

506001

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.426

High

505942

CNDD3
Condensin-2 complex subunit D3

1

3

High-throughput

0.407

High

505994

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

3

High-throughput

0.407

High

58357

CI170
Uncharacterized protein encoded by LINC02872

1

0

High-throughput

0.279

Low

261776

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.279

Low

506088

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low

505947

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

505955

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.249

Low

505985

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

506050

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

506066

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024