HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: BABA2 (Q9NXR7)
BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein)
Gene: BABAM2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

The method score is based on:

Property	Details
Experiments	14636569, 25184681, 29656893, 34591612, 22990118
Identification Methods	affinity chromatography technology, biochemical, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000152 - nuclear ubiquitin ligase complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006282 - regulation of DNA repair and 9 others more... GO:0006302 - double-strand break repair GO:0006974 - DNA damage response GO:0007095 - mitotic G2 DNA damage checkpoint signaling GO:0010212 - response to ionizing radiation GO:0044818 - mitotic G2/M transition checkpoint GO:0045739 - positive regulation of DNA repair GO:0070531 - BRCA1-A complex GO:0071479 - cellular response to ionizing radiation GO:2000001 - regulation of DNA damage checkpoint
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	1863
Hs

1	383

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024