HitPredict

Interactor 1: PRS6B (P33298)
26S proteasome regulatory subunit 6B homolog (Protein YNT1) (Tat-binding homolog 2)
Gene: RPT3

Interactor 2: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	11805837, 37968396, 16554755, 31848235, 22195964
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, cross-linking study, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	JAB~Prot_ATP_ID_OB_C
Common GO terms	GO:0000502 - proteasome complex GO:0006511 - ubiquitin-dependent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Sc			1 338
+	At
		1422014 PRS4A_ARATH (44-419): 3.96e-157: 452: 46.83		PSD7B_ARATH (6-311): 1.9e-100: 300: 49.03
+	At
		200895 PRS4A_ARATH (44-419): 3.96e-157: 452: 46.83		PSD7A_ARATH (6-308): 6.58e-100: 298: 49.18
+	Dm
		684544 PRS4_DROME (17-427): 9.06e-138: 403: 44.10		PSMD7_DROME (4-325): 8.26e-103: 307: 45.68
+	Dm
		198024 PRS8_DROME (44-423): 1.29e-121: 361: 41.32		PSMD7_DROME (4-325): 8.26e-103: 307: 45.68
+	Dm
		684560 Q9V405_DROME (45-428): 5.31e-121: 359: 72.66		PSMD7_DROME (4-325): 8.26e-103: 307: 45.68
+	Dm
		684574 Q9W414_DROME (42-426): 4.41e-121: 359: 40.00		PSMD7_DROME (4-325): 8.26e-103: 307: 45.68
+	Sp
		267630 PRS6B_SCHPO (41-428): 1.22e-123: 365: 78.09		RPN8_SCHPO (5-321): 6.07e-99: 296: 50.78
+	Hs
		906494 PRS4_HUMAN (15-427): 1.84e-124: 369: 44.34		PSMD7_HUMAN (6-301): 2.64e-97: 292: 50.51
+	Hs
		851269 PRS6B_HUMAN (1-428): 1.07e-122: 364: 65.42		PSMD7_HUMAN (6-301): 2.64e-97: 292: 50.51
+	Hs
		906497 PRS10_HUMAN (42-426): 6.2e-123: 363: 37.66		PSMD7_HUMAN (6-301): 2.64e-97: 292: 50.51
+	At
		1442984 PRS4A_ARATH (44-419): 3.96e-157: 452: 46.83		PSDE_ARATH (3-263): 1.26e-46: 161: 17.65
+	Dm
		874995 PRS4_DROME (17-427): 9.06e-138: 403: 44.10		PSDE_DROME (3-264): 6.48e-48: 165: 16.90
+	Sp
		268445 PRS6B_SCHPO (41-428): 1.22e-123: 365: 78.09		RPN11_SCHPO (1-263): 3.36e-61: 199: 19.11
+	Dm
		198064 PRS8_DROME (44-423): 1.29e-121: 361: 41.32		PSDE_DROME (3-264): 6.48e-48: 165: 16.90
+	Dm
		1463624 Q9V405_DROME (45-428): 5.31e-121: 359: 72.66		PSDE_DROME (3-264): 6.48e-48: 165: 16.90
+	Dm
		1463634 Q9W414_DROME (42-426): 4.41e-121: 359: 40.00		PSDE_DROME (3-264): 6.48e-48: 165: 16.90
+	Hs
		138051 PRS4_HUMAN (15-427): 1.84e-124: 369: 44.34		PSDE_HUMAN (6-142): 4.76e-27: 109: 24.65
+	Hs
		138008 PRS6B_HUMAN (1-428): 1.07e-122: 364: 65.42		PSDE_HUMAN (6-142): 4.76e-27: 109: 24.65
+	Hs
		138055 PRS10_HUMAN (42-426): 6.2e-123: 363: 37.66		PSDE_HUMAN (6-142): 4.76e-27: 109: 24.65
+	Hs
		138052 PRS8_HUMAN (30-423): 5.55e-119: 354: 39.59		PSDE_HUMAN (6-142): 4.76e-27: 109: 24.65