HitPredict

Interactor 1: CIC1 (P38779)
Proteasome-interacting protein CIC1 (Core interacting component 1)
Gene: CIC1

Interactor 2: BRX1 (Q08235)
Ribosome biogenesis protein BRX1
Gene: BRX1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	16429126, 12374754, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005730 - nucleolus GO:0030687 - preribosome, large subunit precursor
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 376 Sc			1 291
+	Sc
		733813 CIC1_YEAST (1-376): 1.89e-149: 428: 100.00		RPF2_YEAST (6-282): 1.45e-61: 199: 16.84
+	Sc
		754115 CIC1_YEAST (1-376): 1.89e-149: 428: 100.00		RPF1_YEAST (4-252): 5.84e-52: 173: 14.40
+	Sc
		754113 CIC1_YEAST (1-376): 1.89e-149: 428: 100.00		SSF1_YEAST (10-197): 9.05e-34: 129: 15.64
+	Sc
		754221 CIC1_YEAST (1-376): 1.89e-149: 428: 100.00		SSF2_YEAST (10-197): 8.32e-33: 127: 15.17
+	Hs
		281341 RL1D1_HUMAN (55-294): 6.21e-55: 189: 20.91		BRX1_HUMAN (26-286): 1.92e-85: 261: 47.91
+	Hs
		281418 RL1D1_HUMAN (55-294): 6.21e-55: 189: 20.91		RPF2_HUMAN (1-285): 3.52e-77: 238: 17.57
+	Hs
		281371 RL1D1_HUMAN (55-294): 6.21e-55: 189: 20.91		IMP4_HUMAN (13-255): 9.01e-73: 227: 15.79
+	Hs
		281422 RL1D1_HUMAN (55-294): 6.21e-55: 189: 20.91		RPF1_HUMAN (7-251): 6.1e-62: 201: 17.13
+	Sc
		733559 RL1D1_YEAST (75-292): 1.46e-51: 175: 22.79		RPF2_YEAST (6-282): 1.45e-61: 199: 16.84
+	Sc
		733586 RL1D1_YEAST (75-292): 1.46e-51: 175: 22.79		IMP4_YEAST (5-261): 1.73e-61: 198: 17.76
+	Hs
		281432 RL1D1_HUMAN (55-294): 6.21e-55: 189: 20.91		SSF1_HUMAN (12-281): 5.67e-45: 160: 12.87