HitPredict

Interactor 1: RT107 (P38850)
Regulator of Ty1 transposition protein 107 (Establishes silent chromatin protein 4)
Gene: RTT107

Interactor 2: SMC5 (Q08204)
Structural maintenance of chromosomes protein 5
Gene: SMC5

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	26439300, 21642432, 37968396, 20670896
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1070 Sc			1 1093
+	Sc
		756224 RT107_YEAST (1-1070): 0: 1381: 100.00		SMC6_YEAST (34-1052): 8.61e-47: 184: 12.17
+	Hs
		1221609 TOPB1_HUMAN (342-839): 5.45e-67: 249: 15.41		SMC5_HUMAN (16-1076): 2.66e-85: 301: 23.96
+	Hs
		1266887 TOPB1_HUMAN (342-839): 5.45e-67: 249: 15.41		SMC4_HUMAN (87-1067): 1.34e-41: 168: 9.15
+	Hs
		1056884 MDC1_HUMAN (493-840): 4.69e-17: 89.3: 11.51		SMC5_HUMAN (16-1076): 2.66e-85: 301: 23.96
+	Hs
		1056947 MDC1_HUMAN (493-840): 4.69e-17: 89.3: 11.51		SMC6_HUMAN (13-1064): 7.06e-68: 250: 13.44
+	Hs
		1173281 PAXI1_HUMAN (279-621): 2.71e-10: 66.9: 15.81		SMC3_HUMAN (40-986): 3.81e-46: 183: 12.10
+	Hs
		1056828 MDC1_HUMAN (493-840): 4.69e-17: 89.3: 11.51		SMC1A_HUMAN (162-1050): 5.4e-31: 134: 10.29
+	Hs
		311568 PAXI1_HUMAN (279-621): 2.71e-10: 66.9: 15.81		SMC2_HUMAN (150-1050): 5.68e-32: 137: 10.22
+	Hs
		1057296 PAXI1_HUMAN (279-621): 2.71e-10: 66.9: 15.81		SMC1A_HUMAN (162-1050): 5.4e-31: 134: 10.29
+	Hs
		725246 ECT2_HUMAN (266-571): 2.19e-12: 73.5: 10.65		MYH10_HUMAN (118-573): 2.15e-14: 80.5: 8.04
+	Hs
		725023 ECT2_HUMAN (266-571): 2.19e-12: 73.5: 10.65		MYH9_HUMAN (604-979): 5.21e-13: 75.9: 9.50