HitPredict

Interactor 1: IF4A3 (P38919)
Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]
Gene: EIF4A3

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15324660
Identification Methods	coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 411 Hs			1 245
+	Hs
		892772 IF4A1_HUMAN (7-411): 1.67e-178: 505: 66.75		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Zm
		6553 A0A1D6HQ89_MAIZE (2-411): 5.21e-152: 438: 70.63		A0A1D6E930_MAIZE (1-239): 5.96e-140: 395: 61.81
+	Hs
		757538 IF4A3_HUMAN (1-411): 1.22e-142: 414: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646694 IF4A3_HUMAN (1-411): 1.22e-142: 414: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	At
		788599 RH20_ARATH (3-410): 1.93e-140: 411: 31.40		14333_ARATH (3-239): 1.48e-141: 398: 64.73
+	Hs
		133969 DDX3X_HUMAN (17-410): 2.28e-129: 388: 32.45		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	At
		783414 IF4A1_ARATH (1-411): 1.18e-132: 388: 63.59		14332_ARATH (3-239): 6.89e-143: 401: 65.15
+	Hs
		133888 DDX3X_HUMAN (17-410): 2.28e-129: 388: 32.45		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		757534 IF4A3_HUMAN (1-411): 1.22e-142: 414: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		571384 DDX5_HUMAN (25-411): 6.87e-135: 401: 30.63		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		571326 DDX5_HUMAN (25-411): 6.87e-135: 401: 30.63		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		133957 DDX3X_HUMAN (17-410): 2.28e-129: 388: 32.45		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		133992 DDX3X_HUMAN (17-410): 2.28e-129: 388: 32.45		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Mm
		873099 DDX6_MOUSE (35-407): 6.06e-89: 279: 37.83		1433E_MOUSE (2-241): 9.9e-144: 403: 68.18
+	Hs
		640404 DDX6_HUMAN (35-407): 1.15e-88: 278: 37.83		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		640329 DDX6_HUMAN (35-407): 1.15e-88: 278: 37.83		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		640335 DDX6_HUMAN (35-407): 1.15e-88: 278: 37.83		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		640398 DDX6_HUMAN (35-407): 1.15e-88: 278: 37.83		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Mm
		873100 DDX6_MOUSE (35-407): 6.06e-89: 279: 37.83		1433F_MOUSE (2-240): 1.16e-107: 312: 74.07
+	Hs
		640336 DDX6_HUMAN (35-407): 1.15e-88: 278: 37.83		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97