HitPredict

Interactor 1: GRIK1 (P39086)
Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5)
Gene: GRIK1

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	12597860
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission GO:0007399 - nervous system development GO:0098839 - postsynaptic density membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 918 Hs			1 724
+	Hs
		942335 GRIK2_HUMAN (6-909): 0: 885: 76.46		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Rn
		677766 GRIK2_RAT (12-909): 0: 881: 76.64		DLG4_RAT (1-724): 0: 668: 99.86
+	Mm
		761217 GRIK2_MOUSE (12-909): 0: 881: 76.64		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Rn
		585138 GRIA1_RAT (14-913): 0: 770: 36.83		DLG4_RAT (1-724): 0: 668: 99.86
+	Mm
		1143565 GRIA4_MOUSE (20-918): 0: 767: 36.12		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Mm
		620892 GRIA1_MOUSE (14-913): 0: 767: 36.83		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		786757 GRIA3_HUMAN (1-904): 0: 760: 35.88		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		1143566 GRIA3_MOUSE (7-904): 0: 751: 36.01		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		786726 GRIA2_HUMAN (3-904): 0: 743: 35.53		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		620965 GRIA2_MOUSE (3-904): 0: 740: 35.42		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		942350 GRIK5_HUMAN (19-889): 0: 705: 41.80		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		1142982 GRIK5_MOUSE (19-889): 0: 703: 41.57		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Mm
		620881 GRIA1_MOUSE (14-913): 0: 767: 36.83		DLG3_MOUSE (20-724): 0: 583: 64.08
+	Hs
		1021483 GRIK2_HUMAN (6-909): 0: 885: 76.46		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		1022366 GRIK2_HUMAN (6-909): 0: 885: 76.46		DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58
+	Hs
		786696 GRIA1_HUMAN (14-913): 0: 776: 37.08		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Rn
		585151 GRIA1_RAT (14-913): 0: 770: 36.83		DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97
+	Mm
		620904 GRIA1_MOUSE (14-913): 0: 767: 36.83		DLG2_MOUSE (225-474): 1.48e-18: 92.5: 21.09
+	Rn
		585186 GRIA2_RAT (3-904): 0: 739: 35.42		MPP4_RAT (64-203): 5.72e-17: 85.9: 15.86
+	Hs
		1081918 GRIK5_HUMAN (19-889): 0: 705: 41.80		DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58