HitPredict

Interactor 1: TRAF2 (P39429)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2)
Gene: TRAF2

Interactor 2: TNR3 (P50284)
Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor)
Gene: Ltbr

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	23334419, 15102471
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006915 - apoptotic process GO:0031625 - ubiquitin protein ligase binding GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:2001238 - positive regulation of extrinsic apoptotic signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Mm			1 415
+	Hs
		738659 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TNR3_HUMAN (1-411): 4.13e-117: 350: 66.27
+	Mm
		626852 TRAF2_MOUSE (1-501): 1.58e-154: 451: 100.00		TNR1A_MOUSE (36-331): 2.76e-60: 204: 22.08
+	Hs
		584390 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TNR1A_HUMAN (36-329): 1.62e-57: 197: 22.22
+	Mm
		648951 TRAF2_MOUSE (1-501): 1.58e-154: 451: 100.00		TNR5_MOUSE (25-269): 2.13e-54: 183: 23.58
+	Mm
		192583 TRAF2_MOUSE (1-501): 1.58e-154: 451: 100.00		TNR11_MOUSE (31-259): 8.44e-49: 177: 28.57
+	Mm
		761824 TRAF2_MOUSE (1-501): 1.58e-154: 451: 100.00		TNR14_MOUSE (28-286): 2.22e-51: 175: 25.10
+	Hs
		639576 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TNR5_HUMAN (26-280): 4.03e-54: 182: 23.14
+	Hs
		1020849 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TNR25_HUMAN (44-325): 5.95e-49: 173: 18.21
+	Hs
		591317 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TNR1B_HUMAN (8-229): 5.36e-48: 172: 27.56
+	Hs
		1020846 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TNR14_HUMAN (33-292): 4.87e-46: 161: 22.31
+	Mm
		761804 TRAF2_MOUSE (1-501): 1.58e-154: 451: 100.00		TNR4_MOUSE (21-222): 3.53e-30: 119: 23.27
+	Mm
		761802 TRAF2_MOUSE (1-501): 1.58e-154: 451: 100.00		CD27_MOUSE (24-278): 4.9e-29: 115: 16.34
+	Mm
		591445 TRAF2_MOUSE (1-501): 1.58e-154: 451: 100.00		TNR9_MOUSE (59-273): 6.91e-28: 112: 22.08
+	Hs
		796823 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TNR4_HUMAN (52-222): 2.62e-28: 114: 29.83
+	Hs
		154352 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TR10B_HUMAN (24-176): 2.21e-26: 111: 25.97
+	Hs
		661043 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TNR8_HUMAN (32-188): 3.9e-25: 109: 23.42
+	Hs
		121479 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TR10A_HUMAN (35-175): 2.2e-24: 106: 25.35
+	Hs
		989742 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TNR9_HUMAN (48-229): 9.04e-25: 103: 26.92
+	Hs
		645795 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		CD27_HUMAN (24-149): 5.07e-22: 96.5: 24.22
+	Hs
		436618 TRAF2_HUMAN (1-501): 7.77e-150: 439: 86.83		TNR16_HUMAN (26-130): 2.59e-18: 88.4: 27.10