Protein: RNF34
E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34)

Gene: RNF34
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q969K3

Gene Ontology (top 5):
GO:0002039 - p53 binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1361991

RFFL
E3 ubiquitin-protein ligase rififylin

4

14

Small-scale

0.881

High

957152

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.778

High

982269

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.778

High

1380416

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

5

Small-scale

0.740

High

970881

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

1380400

UBE2F
NEDD8-conjugating enzyme UBE2F

1

20

High-throughput

0.698

High

1105155

U119A
Protein unc-119 homolog A

4

1

High-throughput

0.691

High

931040

HSP72
Heat shock-related 70 kDa protein 2

3

8

High-throughput

0.675

High

906729

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.647

High

909363

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

Small-scale

0.647

High

1380399

RNF34
E3 ubiquitin-protein ligase RNF34

1

15

Small-scale

0.647

High

66014

U119B
Protein unc-119 homolog B

2

1

High-throughput

0.628

High

537655

HSP7C
Heat shock cognate 71 kDa protein

2

8

High-throughput

0.628

High

1380403

KLH15
Kelch-like protein 15

2

2

High-throughput

0.628

High

1380412

SPB13
Serpin B13

2

2

High-throughput

0.628

High

712884

CASP1
Caspase-1

1

20

Small-scale

0.618

High

936962

CASP9
Caspase-9

1

20

Small-scale

0.618

High

1380413

TSR3
18S rRNA aminocarboxypropyltransferase

2

0

High-throughput

0.602

High

69707

EFCB7
EF-hand calcium-binding domain-containing protein 7

2

1

High-throughput

0.574

High

1132404

CASP8
Caspase-8

1

20

Small-scale

0.573

High

1365950

APBP2
Amyloid protein-binding protein 2

1

5

High-throughput

0.573

High

1093286

FLII
Protein flightless-1 homolog

1

1

Small-scale

0.561

High

1380405

ZFY21
Zinc finger FYVE domain-containing protein 21

1

5

Small-scale

0.561

High

1380420

NEMO
NF-kappa-B essential modulator

1

9

Small-scale

0.561

High

1369556

CASPA
Caspase-10

1

20

Small-scale

0.552

High

783363

TRI23
E3 ubiquitin-protein ligase TRIM23

1

9

High-throughput

0.541

High

1380406

PHF7
E3 ubiquitin-protein ligase PHF7

1

2

High-throughput

0.541

High

1365933

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

1

0

Small-scale

0.537

High

1380410

MKS1
Tectonic-like complex member MKS1

1

0

Small-scale

0.537

High

130567

SPT5H
Transcription elongation factor SPT5

1

3

High-throughput

0.536

High

193134

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

7

High-throughput

0.536

High

402985

ANXA1
Annexin A1

1

3

High-throughput

0.536

High

761805

HSP74
Heat shock 70 kDa protein 4

1

9

High-throughput

0.536

High

1278056

MAVS
Mitochondrial antiviral-signaling protein

1

8

Small-scale

0.535

High

167634

GIPC1
PDZ domain-containing protein GIPC1

1

1

High-throughput

0.515

High

384503

CRYAA
Alpha-crystallin A chain

1

3

High-throughput

0.515

High

1199346

GLE1
mRNA export factor GLE1

1

1

High-throughput

0.515

High

1279678

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

1369668

KLK6
Kallikrein-6

1

3

High-throughput

0.515

High

1380417

TF3C3
General transcription factor 3C polypeptide 3

1

7

High-throughput

0.515

High

993469

SPT4H
Transcription elongation factor SPT4

1

0

High-throughput

0.513

High

1380404

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.513

High

1380407

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1380418

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

1380419

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

422794

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

1031936

NC2B
Protein Dr1

1

0

High-throughput

0.493

High

1380408

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.493

High

1380402

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

Small-scale

0.481

High

345099

RIGI
Antiviral innate immune response receptor RIG-I

1

12

Small-scale

0.479

High

414355

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

631392

RAB5A
Ras-related protein Rab-5A

1

4

Small-scale

0.479

High

772185

MSX2
Homeobox protein MSX-2

1

1

High-throughput

0.479

High

1086888

CDC20
Cell division cycle protein 20 homolog

1

5

Small-scale

0.479

High

1095739

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

11

Small-scale

0.479

High

1290921

TAXB1
Tax1-binding protein 1

1

8

Small-scale

0.479

High

1380401

SH3K1
SH3 domain-containing kinase-binding protein 1

1

4

High-throughput

0.479

High

1380411

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

1

Small-scale

0.479

High

1380414

ANC2
Anaphase-promoting complex subunit 2

1

7

Small-scale

0.479

High

1380415

FZR1
Fizzy-related protein homolog

1

5

Small-scale

0.479

High

109483

G5E9A7
DM1 locus, WD repeat containing

1

7

High-throughput

0.470

High

1226486

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.458

High

700470

PSB8
Proteasome subunit beta type-8

1

6

High-throughput

0.445

High

1276056

ZN550
Zinc finger protein 550

1

0

High-throughput

0.426

High

1380409

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.328

High

505189

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025