HitPredict

Interactor 1: PROF (P39825)
Profilin
Gene: cdc3

Interactor 2: CDC12 (Q10059)
Cell division control protein 12
Gene: CDC12

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	9105045, 18305104
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030041 - actin filament polymerization GO:0031097 - medial cortex GO:0043332 - mating projection tip GO:1903475 - mitotic actomyosin contractile ring assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 127 Sp			1 1841
+	Hs
		237549 PROF1_HUMAN (3-127): 3.4e-36: 122: 27.14		DIAP1_HUMAN (171-1478): 0: 712: 15.13
+	Hs
		237564 PROF2_HUMAN (3-127): 3.53e-32: 112: 27.14		DIAP1_HUMAN (171-1478): 0: 712: 15.13
+	Hs
		430352 PROF1_HUMAN (3-127): 3.4e-36: 122: 27.14		DIAP3_HUMAN (696-1542): 2.53e-111: 386: 17.18
+	Sc
		425514 PROF_YEAST (1-127): 2.38e-48: 152: 52.76		BNR1_YEAST (957-1474): 1.66e-95: 342: 23.90
+	At
		221287 PRF3_ARATH (1-126): 4.26e-54: 168: 36.64		FH4_ARATH (964-1389): 4.48e-92: 319: 13.98
+	Hs
		430404 PROF1_HUMAN (3-127): 3.4e-36: 122: 27.14		FHOD1_HUMAN (977-1559): 2.98e-102: 359: 12.99
+	At
		221286 PRF2_ARATH (1-126): 2.09e-51: 160: 35.12		FH4_ARATH (964-1389): 4.48e-92: 319: 13.98
+	Hs
		243087 PROF1_HUMAN (3-127): 3.4e-36: 122: 27.14		DIAP2_HUMAN (508-1449): 3.3e-96: 340: 13.78
+	Dm
		639180 PROF_DROME (1-127): 1.08e-50: 158: 37.01		DIA_DROME (206-663): 8.89e-84: 302: 14.14
+	Sc
		425515 PROF_YEAST (1-127): 2.38e-48: 152: 52.76		BNI1_YEAST (280-846): 3.57e-81: 300: 16.91
+	Ce
		109520 PROF1_CAEEL (1-127): 3.22e-38: 127: 32.58		H2KYI3_CAEEL (171-687): 1.91e-82: 302: 14.41
+	Hs
		430356 PROF1_HUMAN (3-127): 3.4e-36: 122: 27.14		FMN2_HUMAN (936-1386): 6.2e-81: 298: 16.60
+	Dm
		639194 PROF_DROME (1-127): 1.08e-50: 158: 37.01		Q8IRY0_DROME (222-855): 8.19e-70: 259: 13.13
+	Hs
		430307 PROF1_HUMAN (3-127): 3.4e-36: 122: 27.14		FMNL2_HUMAN (261-606): 4.32e-59: 225: 13.88
+	Dd
		640684 PROF2_DICDI (1-124): 3.69e-40: 132: 49.19		FORH_DICDI (212-769): 9.27e-53: 205: 14.41
+	Hs
		430197 PROF1_HUMAN (3-127): 3.4e-36: 122: 27.14		INF2_HUMAN (268-636): 5.19e-54: 210: 16.58
+	Hs
		714970 PROF2_HUMAN (3-127): 3.53e-32: 112: 27.14		INF2_HUMAN (268-636): 5.19e-54: 210: 16.58
+	Hs
		314830 PROF1_HUMAN (3-127): 3.4e-36: 122: 27.14		FMNL1_HUMAN (261-612): 3.74e-50: 197: 11.73
+	Hs
		314847 PROF2_HUMAN (3-127): 3.53e-32: 112: 27.14		FMNL1_HUMAN (261-612): 3.74e-50: 197: 11.73
+	Dm
		639185 PROF_DROME (1-127): 1.08e-50: 158: 37.01		CAPU_DROME (914-1440): 6.47e-35: 148: 17.21