Interactor 1: GDNF (P39905)
Glial cell line-derived neurotrophic factor (hGDNF) (Astrocyte-derived trophic factor) (ATF)
Gene: GDNF

Interactor 2: GFRA1 (P56159)
GDNF family receptor alpha-1 (GDNF receptor alpha-1) (GDNFR-alpha-1) (GFR-alpha-1) (RET ligand 1) (TGF-beta-related neurotrophic factor receptor 1)
Gene: GFRA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.845

The method score is based on:

Property Details
Experiments 9407096, 10829012, 20473317
Identification Methods pull down, enzyme linked immunosorbent assay
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains GDNF~TGF_beta
Common GO terms GO:0005102 - signaling receptor binding
GO:0005794 - Golgi apparatus
GO:0007399 - nervous system development
GO:0031175 - neuron projection development
GO:0035860 - glial cell-derived neurotrophic factor receptor signaling pathway
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 211
Hs

1 465
+ Rn
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024