Protein: LRP5
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)

Gene: LRP5
Organism: Homo sapiens
Interactions: 104
UniProt ID: O75197

Gene Ontology (top 5):
GO:0001702 - gastrulation with mouth forming second
GO:0002053 - positive regulation of mesenchymal cell proliferation
GO:0002076 - osteoblast development
GO:0005783 - endoplasmic reticulum
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

274911

SOST
Sclerostin

4

6

Small-scale

0.896

High

274845

DKK1
Dickkopf-related protein 1

3

8

High-throughput

0.861

High

274849

FA9
Coagulation factor IX

2

8

High-throughput

0.811

High

274894

SPA12
Serpin A12

2

1

High-throughput

0.811

High

274920

LRC4C
Leucine-rich repeat-containing protein 4C

2

3

High-throughput

0.811

High

274881

SUSD4
Sushi domain-containing protein 4

3

4

High-throughput

0.770

High

62190

PRS37
Probable inactive serine protease 37

2

19

High-throughput

0.726

High

274929

DKK4
Dickkopf-related protein 4

2

8

High-throughput

0.726

High

168351

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.691

High

274915

SIRPD
Signal-regulatory protein delta

1

2

High-throughput

0.691

High

274862

ETV6
Transcription factor ETV6

4

1

High-throughput

0.691

High

274887

BRNP3
BMP/retinoic acid-inducible neural-specific protein 3

2

0

High-throughput

0.679

High

274899

PAR16
Protein mono-ADP-ribosyltransferase PARP16

3

1

High-throughput

0.667

High

274903

LIPH
Lipase member H

3

6

High-throughput

0.667

High

274908

RHES
GTP-binding protein Rhes

3

6

High-throughput

0.667

High

181036

AXIN1
Axin-1

3

5

Small-scale

0.640

High

274919

SG196
Protein O-mannose kinase

4

1

High-throughput

0.638

High

274905

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

5

High-throughput

0.628

High

274931

DKKL1
Dickkopf-like protein 1

2

1

High-throughput

0.628

High

273736

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

6

High-throughput

0.618

High

274851

KLK3
Prostate-specific antigen

1

15

High-throughput

0.618

High

274916

KLK15
Kallikrein-15

1

11

High-throughput

0.618

High

274930

DKK2
Dickkopf-related protein 2

1

8

High-throughput

0.618

High

274933

KLK5
Kallikrein-5

1

11

High-throughput

0.618

High

274844

LRP6
Low-density lipoprotein receptor-related protein 6

1

11

Small-scale

0.618

High

274877

TAZ
Tafazzin

3

4

High-throughput

0.609

High

274888

CHST9
Carbohydrate sulfotransferase 9

3

1

High-throughput

0.609

High

274891

TF2LY
Homeobox protein TGIF2LY

3

1

High-throughput

0.604

High

143720

WN10B
Protein Wnt-10b

2

16

High-throughput

0.601

High

274882

CAPR2
Caprin-2

1

4

Small-scale

0.578

High

274846

NXPH2
Neurexophilin-2

2

2

High-throughput

0.574

High

274847

SG1D1
Secretoglobin family 1D member 1

2

3

High-throughput

0.574

High

274863

KC1A
Casein kinase I isoform alpha

2

4

High-throughput

0.574

High

274864

FCGRN
IgG receptor FcRn large subunit p51

2

5

High-throughput

0.574

High

274889

PODN
Podocan

2

2

High-throughput

0.574

High

274913

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

2

8

High-throughput

0.574

High

274927

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

2

High-throughput

0.574

High

229177

B3GT2
Beta-1,3-galactosyltransferase 2

2

4

High-throughput

0.558

High

274848

LGI1
Leucine-rich glioma-inactivated protein 1

1

4

High-throughput

0.536

High

274852

CFC1
Cryptic protein

1

2

High-throughput

0.536

High

274854

EDN3
Endothelin-3

1

3

High-throughput

0.536

High

274858

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

High-throughput

0.536

High

274873

IL5RA
Interleukin-5 receptor subunit alpha

1

6

High-throughput

0.536

High

274895

NRSN1
Neurensin-1

1

1

High-throughput

0.536

High

274897

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.536

High

274898

RNF10
E3 ubiquitin-protein ligase RNF10

1

1

High-throughput

0.536

High

274906

CLC2B
C-type lectin domain family 2 member B

1

2

High-throughput

0.536

High

274914

WN10A
Protein Wnt-10a

1

16

High-throughput

0.536

High

274921

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

274932

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

8

High-throughput

0.536

High

274935

LIPG
Endothelial lipase

1

6

High-throughput

0.536

High

274892

RBM45
RNA-binding protein 45

1

0

High-throughput

0.513

High

274893

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.513

High

274902

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.513

High

274928

DNJB9
DnaJ homolog subfamily B member 9

1

0

High-throughput

0.513

High

274917

FZD8
Frizzled-8

1

5

Small-scale

0.501

High

274896

APCD1
Protein APCDD1

1

0

Small-scale

0.493

High

191426

SIA8E
Alpha-2,8-sialyltransferase 8E

1

5

High-throughput

0.489

High

224453

PI15
Peptidase inhibitor 15

1

5

High-throughput

0.489

High

274853

PRG2
Bone marrow proteoglycan

1

6

High-throughput

0.489

High

274856

CRIS2
Cysteine-rich secretory protein 2

1

5

High-throughput

0.489

High

274861

TIMP3
Metalloproteinase inhibitor 3

1

4

High-throughput

0.489

High

274874

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

5

High-throughput

0.489

High

274879

DB135
Beta-defensin 135

1

1

High-throughput

0.489

High

274880

NMS
Neuromedin-S

1

2

High-throughput

0.489

High

274883

LYZL1
Lysozyme-like protein 1

1

3

High-throughput

0.489

High

274884

IGFL3
Insulin growth factor-like family member 3

1

6

High-throughput

0.489

High

274886

CHSS3
Chondroitin sulfate synthase 3

1

4

High-throughput

0.489

High

274900

KC1AL
Casein kinase I isoform alpha-like

1

4

High-throughput

0.489

High

274901

ZN383
Zinc finger protein 383

1

13

High-throughput

0.489

High

274907

CCL17
C-C motif chemokine 17

1

2

High-throughput

0.489

High

274912

OVOL2
Transcription factor Ovo-like 2

1

19

High-throughput

0.489

High

274922

GPTC2
G patch domain-containing protein 2

1

1

High-throughput

0.489

High

274926

DNM3B
DNA

1

1

High-throughput

0.489

High

181840

SMAD9
Mothers against decapentaplegic homolog 9

1

0

High-throughput

0.486

High

217607

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

274855

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

High-throughput

0.479

High

274859

CTNB1
Catenin beta-1

1

3

Small-scale

0.479

High

274860

BASI
Basigin

1

5

High-throughput

0.479

High

274867

RAC3
Ras-related C3 botulinum toxin substrate 3

1

12

High-throughput

0.479

High

274868

CDC42
Cell division control protein 42 homolog

1

12

High-throughput

0.479

High

274869

RHOA
Transforming protein RhoA

1

12

High-throughput

0.479

High

274870

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

High-throughput

0.479

High

274918

RHOJ
Rho-related GTP-binding protein RhoJ

1

15

High-throughput

0.479

High

274923

ELOV5
Very long chain fatty acid elongase 5

1

3

High-throughput

0.479

High

274934

TRAF6
TNF receptor-associated factor 6

1

4

Small-scale

0.479

High

170578

CLGN
Calmegin

1

7

High-throughput

0.445

High

274865

WNT3A
Protein Wnt-3a

1

16

High-throughput

0.445

High

274871

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.445

High

274872

NDP
Norrin

1

2

Small-scale

0.445

High

274875

LRC32
Transforming growth factor beta activator LRRC32

1

1

High-throughput

0.445

High

274876

SL9A5
Sodium/hydrogen exchanger 5

1

5

High-throughput

0.445

High

274890

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

1

High-throughput

0.445

High

274910

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

2

High-throughput

0.437

High

274925

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.437

High

274850

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

274885

CCNI2
Cyclin-I2

1

1

High-throughput

0.407

High

274866

FAM3B
Protein FAM3B

2

0

High-throughput

0.328

High

274878

ODAPH
Odontogenesis associated phosphoprotein

2

0

High-throughput

0.328

High

60864

COLL1
Colipase-like protein 1

1

0

High-throughput

0.279

Low

274904

DNS2B
Deoxyribonuclease-2-beta

1

0

High-throughput

0.279

Low

274909

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

274924

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.279

Low

274857

STMN1
Stathmin

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025