HitPredict

Interactor 1: AFG3 (P39925)
Mitochondrial inner membrane m-AAA protease component YTA10 (EC 3.4.24.-) (EC 3.6.-.-) (ATPase family gene 3 protein) (Tat-binding homolog 10)
Gene: AFG3

Interactor 2: PHB1 (P40961)
Prohibitin-1
Gene: PHB1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	15525670, 16429126, 37968396, 32051233, 16239145
Identification Methods	affinity chromatography technology, cross-linking study, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 761 Sc			1 287
+	Sc
		764776 AFG3_YEAST (1-761): 0: 630: 100.00		PHB2_YEAST (25-276): 3.11e-77: 239: 55.56
+	Hs
		1305325 AFG32_HUMAN (1-756): 0: 549: 45.06		PHB2_HUMAN (1-287): 7.14e-92: 276: 45.83
+	Hs
		719266 AFG32_HUMAN (1-756): 0: 549: 45.06		PHB1_HUMAN (4-269): 8.83e-87: 261: 53.76
+	At
		138214 FTSHA_ARATH (3-735): 6.91e-179: 534: 44.49		PHB3_ARATH (3-269): 3.57e-83: 252: 57.30
+	At
		1258446 FTSHA_ARATH (3-735): 6.91e-179: 534: 44.49		PHB2_ARATH (4-261): 1.54e-82: 251: 52.33
+	At
		1258445 FTSHA_ARATH (3-735): 6.91e-179: 534: 44.49		PHB6_ARATH (9-261): 2.04e-79: 243: 50.99
+	At
		221625 FTSHA_ARATH (3-735): 6.91e-179: 534: 44.49		PHB1_ARATH (7-261): 1.49e-78: 241: 51.77
+	Sc
		772369 YTA12_YEAST (22-747): 3.09e-167: 504: 52.52		PHB1_YEAST (1-287): 3.5e-86: 261: 100.00
+	Sc
		772371 YTA12_YEAST (22-747): 3.09e-167: 504: 52.52		PHB2_YEAST (25-276): 3.11e-77: 239: 55.56
+	Hs
		1303088 YMEL1_HUMAN (160-737): 2.62e-131: 410: 32.99		PHB2_HUMAN (1-287): 7.14e-92: 276: 45.83