HitPredict

Interactor 1: IMB4 (P40069)
Importin subunit beta-4 (Importin-123) (Karyopherin subunit beta-4) (Karyopherin-123) (Ran-binding protein YRB4)
Gene: KAP123

Interactor 2: NUP57 (P48837)
Nucleoporin NUP57 (Nuclear pore protein NUP57)
Gene: NUP57

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	9864357, 11387327, 9368759, 22357553
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005643 - nuclear pore GO:0006606 - protein import into nucleus GO:0006607 - NLS-bearing protein import into nucleus GO:0051028 - mRNA transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1113 Sc			1 541
+	Sc
		687967 IMB3_YEAST (5-1065): 1.11e-110: 372: 17.51		NUP57_YEAST (1-541): 1.51e-93: 297: 100.00
+	Sc
		767656 IMB4_YEAST (1-1113): 2.41e-177: 551: 100.00		NU159_YEAST (5-321): 5.81e-20: 96.3: 15.46
+	Hs
		127197 IPO5_HUMAN (7-1105): 0: 563: 18.50		NU214_HUMAN (17-255): 5.03e-10: 64.6: 22.76
+	Hs
		127218 IPO5_HUMAN (7-1105): 0: 563: 18.50		NU153_HUMAN (4-290): 7.4e-09: 60.8: 15.46
+	Sc
		767712 IMB4_YEAST (1-1113): 2.41e-177: 551: 100.00		NU100_YEAST (12-279): 1.74e-12: 72.4: 29.41
+	Sc
		697934 IMB4_YEAST (1-1113): 2.41e-177: 551: 100.00		SLA1_YEAST (3-292): 4.47e-12: 71.2: 16.43
+	Sc
		767710 IMB4_YEAST (1-1113): 2.41e-177: 551: 100.00		NUP49_YEAST (45-298): 1.04e-09: 62.8: 23.11
+	Sc
		767713 IMB4_YEAST (1-1113): 2.41e-177: 551: 100.00		NU116_YEAST (1-282): 6.89e-09: 60.8: 22.95
+	Sc
		687969 IMB3_YEAST (5-1065): 1.11e-110: 372: 17.51		NU145_YEAST (4-393): 1.5e-42: 165: 21.52
+	Ce
		136533 Q9N5V3_CAEEL (6-1075): 2.67e-132: 431: 17.00		O01576_CAEEL (1-280): 3.23e-10: 65.1: 23.53
+	Ce
		1341732 Q9N5V3_CAEEL (6-1075): 2.67e-132: 431: 17.00		Q9XWK3_CAEEL (1-212): 3e-10: 64.7: 24.54
+	Sc
		687954 IMB3_YEAST (5-1065): 1.11e-110: 372: 17.51		NU159_YEAST (5-321): 5.81e-20: 96.3: 15.46
+	Hs
		867108 CAND1_HUMAN (1-1112): 1.78e-93: 327: 11.03		SC24C_HUMAN (4-306): 2.13e-34: 140: 11.44
+	Sc
		687986 IMB3_YEAST (5-1065): 1.11e-110: 372: 17.51		NU100_YEAST (12-279): 1.74e-12: 72.4: 29.41
+	Sc
		687985 IMB3_YEAST (5-1065): 1.11e-110: 372: 17.51		NUP49_YEAST (45-298): 1.04e-09: 62.8: 23.11
+	Sc
		687987 IMB3_YEAST (5-1065): 1.11e-110: 372: 17.51		NU116_YEAST (1-282): 6.89e-09: 60.8: 22.95
+	Hs
		858024 TNPO1_HUMAN (215-1056): 1.35e-74: 267: 12.02		NUP98_HUMAN (68-329): 1.41e-14: 79.4: 16.10
+	Hs
		727300 TNPO1_HUMAN (215-1056): 1.35e-74: 267: 12.02		NU214_HUMAN (17-255): 5.03e-10: 64.6: 22.76
+	Hs
		834652 TNPO1_HUMAN (215-1056): 1.35e-74: 267: 12.02		NU153_HUMAN (4-290): 7.4e-09: 60.8: 15.46
+	Hs
		155550 TNPO2_HUMAN (215-1056): 9.61e-71: 256: 12.73		NU153_HUMAN (4-290): 7.4e-09: 60.8: 15.46