Protein: SYLC
Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS)

Gene: SYLC, LARS1
Organism: Homo sapiens
Interactions: 239
UniProt ID: Q9P2J5

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0004819 - glutamine-tRNA ligase activity
GO:0004823 - leucine-tRNA ligase activity
GO:0005096 - GTPase activator activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

834548

SYIC
Isoleucine--tRNA ligase, cytoplasmic

7

5

Small-scale

0.960

High

940324

SYMC
Methionine--tRNA ligase, cytoplasmic

3

14

High-throughput

0.861

High

926552

SYRC
Arginine--tRNA ligase, cytoplasmic

4

2

Small-scale

0.705

High

460650

SYEP
Bifunctional glutamate/proline--tRNA ligase

4

16

Small-scale

0.694

High

140466

SDCB1
Syntenin-1

4

1

High-throughput

0.691

High

1096649

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

4

2

Small-scale

0.686

High

214245

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

3

9

High-throughput

0.667

High

576840

SYDC
Aspartate--tRNA ligase, cytoplasmic

3

14

High-throughput

0.667

High

1114521

CUL3
Cullin-3

3

4

High-throughput

0.667

High

60530

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

12

High-throughput

0.628

High

868270

SYQ
Glutamine--tRNA ligase

2

6

High-throughput

0.628

High

1089358

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

2

8

High-throughput

0.628

High

1139692

SYK
Lysine--tRNA ligase

2

14

High-throughput

0.628

High

1286591

SDCG8
Serologically defined colon cancer antigen 8

2

4

High-throughput

0.628

High

687882

SYVC
Valine--tRNA ligase

1

8

High-throughput

0.618

High

397119

ESR1
Estrogen receptor

2

4

Small-scale

0.585

High

243176

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

346435

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

4

High-throughput

0.584

High

619945

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

1095063

DUS4
Dual specificity protein phosphatase 4

2

3

High-throughput

0.571

High

688175

EF1G
Elongation factor 1-gamma

1

4

Small-scale

0.561

High

1322662

RPTOR
Regulatory-associated protein of mTOR

1

5

Small-scale

0.558

High

839393

MTOR
Serine/threonine-protein kinase mTOR

1

1

Small-scale

0.554

High

1447132

RRAGD
Ras-related GTP-binding protein D

1

2

Small-scale

0.554

High

540961

ERG
Transcriptional regulator ERG

1

2

High-throughput

0.541

High

302988

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

7

High-throughput

0.536

High

641052

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.536

High

970149

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

1126563

CAPR1
Caprin-1

1

2

High-throughput

0.536

High

1136078

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

1157566

PKN2
Serine/threonine-protein kinase N2

1

6

High-throughput

0.536

High

1360515

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.536

High

1412240

ATGA1
Autophagy-related protein 101

1

1

High-throughput

0.536

High

475039

VIME
Vimentin

1

2

High-throughput

0.515

High

860993

RS10
Small ribosomal subunit protein eS10

1

2

High-throughput

0.515

High

135724

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

271582

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

361367

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

1386397

FAF2
FAS-associated factor 2

1

0

High-throughput

0.513

High

1430993

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1454644

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.513

High

955711

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.501

High

1454635

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

276190

NIPS2
Protein NipSnap homolog 2

1

1

High-throughput

0.489

High

288142

FOXH1
Forkhead box protein H1

1

18

High-throughput

0.489

High

484668

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

4

High-throughput

0.489

High

1061620

FOXM1
Forkhead box protein M1

1

15

High-throughput

0.489

High

1337706

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.489

High

1407767

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.489

High

1420509

FOXQ1
Forkhead box protein Q1

1

19

High-throughput

0.489

High

124976

GTPB1
GTP-binding protein 1

1

16

High-throughput

0.479

High

132357

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

169152

ML12B
Myosin regulatory light chain 12B

1

2

High-throughput

0.479

High

180089

BET1
BET1 homolog

1

2

High-throughput

0.479

High

276929

VPS4B
Vacuolar protein sorting-associated protein 4B

1

7

High-throughput

0.479

High

290186

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.479

High

294461

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

316105

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

325144

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

353601

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.479

High

373372

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

412734

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

414760

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

418758

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

2

High-throughput

0.479

High

425662

ISG15
Ubiquitin-like protein ISG15

1

4

High-throughput

0.479

High

447881

TPM3
Tropomyosin alpha-3 chain

1

2

High-throughput

0.479

High

457748

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

461999

HS90A
Heat shock protein HSP 90-alpha

1

11

High-throughput

0.479

High

468869

HS90B
Heat shock protein HSP 90-beta

1

11

High-throughput

0.479

High

476052

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

2

High-throughput

0.479

High

482972

TPM1
Tropomyosin alpha-1 chain

1

2

High-throughput

0.479

High

521455

ARAF
Serine/threonine-protein kinase A-Raf

1

5

High-throughput

0.479

High

533028

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

538039

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

589917

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

607179

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

650463

FGFR3
Fibroblast growth factor receptor 3

1

16

High-throughput

0.479

High

658448

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

668056

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

697681

PYR1
Multifunctional protein CAD

1

3

High-throughput

0.479

High

720810

PUR8
Adenylosuccinate lyase

1

1

High-throughput

0.479

High

731661

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

766915

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

777782

VGFR3
Vascular endothelial growth factor receptor 3

1

8

High-throughput

0.479

High

787092

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

7

High-throughput

0.479

High

791793

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

799539

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

800584

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.479

High

821604

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.479

High

827950

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.479

High

831570

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

834373

GARS
Glycine--tRNA ligase

1

3

High-throughput

0.479

High

840816

RS27
Small ribosomal subunit protein eS27

1

2

High-throughput

0.479

High

867478

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

872832

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

883348

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.479

High

899263

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.479

High

907610

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

927159

ATX3
Ataxin-3

1

2

High-throughput

0.479

High

930067

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

969709

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.479

High

971223

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

979319

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

989149

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

990822

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

993008

RACK1
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.479

High

993362

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.479

High

995864

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

996373

EF1A1
Elongation factor 1-alpha 1

1

6

High-throughput

0.479

High

1026573

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1045860

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1095829

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

High-throughput

0.479

High

1107294

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1108734

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.479

High

1122574

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1135833

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

1137186

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

2

High-throughput

0.479

High

1138131

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.479

High

1138710

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

7

High-throughput

0.479

High

1140974

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1194432

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

1199388

GLE1
mRNA export factor GLE1

1

2

High-throughput

0.479

High

1208073

CYTSB
Cytospin-B

1

2

High-throughput

0.479

High

1218684

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

1227614

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

1229731

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1247023

RICTR
Rapamycin-insensitive companion of mTOR

1

3

High-throughput

0.479

High

1255904

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1258402

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

1280564

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

8

High-throughput

0.479

High

1288596

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.479

High

1289678

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1335025

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

1348556

LNX1
E3 ubiquitin-protein ligase LNX

1

1

Small-scale

0.479

High

1352000

RBCC1
RB1-inducible coiled-coil protein 1

1

5

High-throughput

0.479

High

1364287

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

1364641

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1368167

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.479

High

1369504

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.479

High

1380219

FBXW7
F-box/WD repeat-containing protein 7

1

5

Small-scale

0.479

High

1386615

OPTN
Optineurin

1

9

High-throughput

0.479

High

1388652

SPDLY
Protein Spindly

1

3

High-throughput

0.479

High

1397513

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1405693

NECD
Necdin

1

1

High-throughput

0.479

High

1407927

ANM1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.479

High

1411743

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

1417077

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

1428398

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

6

High-throughput

0.479

High

1429241

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

4

High-throughput

0.479

High

1430612

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

1434111

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

1447380

ANLN
Anillin

1

2

High-throughput

0.479

High

1449236

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1450591

ATD3A
ATPase family AAA domain-containing protein 3A

1

8

High-throughput

0.479

High

1451296

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

1451490

OXSM
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

1

1

High-throughput

0.479

High

1454632

DUX4
Double homeobox protein 4

1

4

High-throughput

0.479

High

1454633

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1454634

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

4

High-throughput

0.479

High

1454638

MYO6
Unconventional myosin-VI

1

2

High-throughput

0.479

High

1454640

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.479

High

1454641

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

1454645

NEMO
NF-kappa-B essential modulator

1

7

High-throughput

0.479

High

258474

EDF1
Endothelial differentiation-related factor 1

1

0

High-throughput

0.458

High

429035

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.458

High

612806

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

716986

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

732422

PRDX2
Peroxiredoxin-2

1

0

High-throughput

0.458

High

765079

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

884409

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

898262

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

Small-scale

0.458

High

983353

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

984572

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

1028901

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

0

High-throughput

0.458

High

1087326

STX4
Syntaxin-4

1

0

High-throughput

0.458

High

1093326

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.458

High

1293686

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1311986

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.458

High

964484

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.457

High

605224

TAL1
T-cell acute lymphocytic leukemia protein 1

1

1

High-throughput

0.457

High

776141

SOX5
Transcription factor SOX-5

1

1

High-throughput

0.457

High

846938

ETV4
ETS translocation variant 4

1

2

High-throughput

0.457

High

401626

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.445

High

430453

JUN
Transcription factor Jun

1

10

High-throughput

0.445

High

564486

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

765959

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

935222

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.445

High

1050560

UBE3A
Ubiquitin-protein ligase E3A

1

6

High-throughput

0.445

High

1365016

TSC1
Hamartin

1

5

Small-scale

0.445

High

1454642

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.445

High

1448514

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

106779

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

161519

KMT2D
Histone-lysine N-methyltransferase 2D

1

2

High-throughput

0.437

High

189019

TMPS2
Transmembrane protease serine 2

1

3

High-throughput

0.437

High

194376

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.437

High

352578

TOP3B
DNA topoisomerase 3-beta-1

1

2

High-throughput

0.437

High

389549

FINC
Fibronectin

1

3

High-throughput

0.437

High

419249

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.437

High

565486

ITA4
Integrin alpha-4

1

2

High-throughput

0.437

High

643115

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

696738

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

769394

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

879564

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

980469

H4
Histone H4

1

2

High-throughput

0.437

High

1100476

TIF1B
Transcription intermediary factor 1-beta

1

4

High-throughput

0.437

High

1186154

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.437

High

1241823

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.437

High

1249286

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1271422

KCTD9
BTB/POZ domain-containing protein KCTD9

1

3

High-throughput

0.437

High

1276899

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1286944

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

1290787

ZCH18
Zinc finger CCCH domain-containing protein 18

1

2

High-throughput

0.437

High

1348235

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

1385268

LENG1
Leukocyte receptor cluster member 1

1

1

High-throughput

0.437

High

1418492

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

1436474

AKTIP
AKT-interacting protein

1

2

Small-scale

0.437

High

1436816

WDR76
WD repeat-containing protein 76

1

15

High-throughput

0.437

High

1438933

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.437

High

1454636

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

High-throughput

0.437

High

1454639

TRI33
E3 ubiquitin-protein ligase TRIM33

1

5

High-throughput

0.437

High

1454643

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

1147

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

1367475

ESR2
Estrogen receptor beta

1

4

High-throughput

0.407

High

1395419

NEUL4
Neuralized-like protein 4

1

1

High-throughput

0.407

High

1420745

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.407

High

1434563

VIAAT
Vesicular inhibitory amino acid transporter

1

2

High-throughput

0.407

High

887286

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.373

High

940699

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

2

0

High-throughput

0.313

High

249210

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

1387681

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

1415893

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

631004

RAB4A
Ras-related protein Rab-4A

1

0

High-throughput

0.249

Low

784755

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.249

Low

1326936

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

1330425

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1452684

TMOD3
Tropomodulin-3

1

0

High-throughput

0.249

Low

1454637

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low

344349

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

425204

IPSP
Plasma serine protease inhibitor

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025