Protein: SYCM
Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)

Gene: SYCM, CARS2
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q9HA77

Gene Ontology (top 5):
GO:0004817 - cysteine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0006423 - cysteinyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1415676

TR61B
tRNA

3

1

High-throughput

0.667

High

1162560

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

1

Small-scale

0.640

High

1203461

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

1434441

RGCC
Regulator of cell cycle RGCC

3

0

High-throughput

0.638

High

242969

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

279921

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

1087560

GRSF1
G-rich sequence factor 1

2

2

High-throughput

0.584

High

1428364

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

7

High-throughput

0.563

High

457130

CAN1
Calpain-1 catalytic subunit

1

0

High-throughput

0.513

High

1430508

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.513

High

952350

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

7

High-throughput

0.501

High

1433441

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.481

High

66298

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

1

High-throughput

0.479

High

183742

RT12
Small ribosomal subunit protein uS12m

1

2

High-throughput

0.479

High

227672

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

282090

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

287383

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

292233

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

351002

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

363877

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

471258

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

519232

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

530390

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.479

High

532980

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

786267

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.479

High

828966

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

841958

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

852036

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

856388

IF2M
Translation initiation factor IF-2, mitochondrial

1

6

High-throughput

0.479

High

869085

TISD
mRNA decay activator protein ZFP36L2

1

1

High-throughput

0.479

High

882896

EFTU
Elongation factor Tu, mitochondrial

1

9

High-throughput

0.479

High

1024192

TFAM
Transcription factor A, mitochondrial

1

2

High-throughput

0.479

High

1048704

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1058284

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1083757

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

1090548

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

1117847

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1123434

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

1142672

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1207147

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1234532

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1240342

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

2

High-throughput

0.479

High

1241351

CH082
UPF0598 protein C8orf82

1

1

High-throughput

0.479

High

1255594

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1271560

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

1272999

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

6

High-throughput

0.479

High

1310421

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

1381729

FAKD4
FAST kinase domain-containing protein 4

1

6

High-throughput

0.479

High

1383561

MCUR1
Mitochondrial calcium uniporter regulator 1

1

2

High-throughput

0.479

High

1388277

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

1388414

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

1401624

EFGM
Elongation factor G, mitochondrial

1

6

High-throughput

0.479

High

1403433

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.479

High

1412441

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1412591

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

1414092

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.479

High

1418887

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

1428734

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1431965

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

1432625

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

1433723

MTG2
Mitochondrial ribosome-associated GTPase 2

1

3

High-throughput

0.479

High

1433927

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1435788

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1436090

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

1437457

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

3

Small-scale

0.479

High

1437458

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.479

High

1437459

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

3

High-throughput

0.479

High

1437460

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

2

High-throughput

0.479

High

1437461

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

1437462

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

6

High-throughput

0.479

High

1437463

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1437464

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

1437465

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1437467

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.479

High

1290043

PNM8A
Paraneoplastic antigen-like protein 8A

1

1

High-throughput

0.470

High

1271148

TM10C
tRNA methyltransferase 10 homolog C

1

0

Small-scale

0.458

High

186034

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.457

High

328162

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

7

High-throughput

0.457

High

1430333

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

7

High-throughput

0.457

High

1433201

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

7

High-throughput

0.457

High

944075

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.457

High

1436752

GHC1
Mitochondrial glutamate carrier 1

1

1

High-throughput

0.445

High

1395029

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

589729

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

696549

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

769216

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1015797

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

1138650

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.437

High

653576

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

215730

COCH
Cochlin

1

0

High-throughput

0.279

Low

1249703

LYPD2
Ly6/PLAUR domain-containing protein 2

1

0

High-throughput

0.279

Low

1437466

TCAL9
Transcription elongation factor A protein-like 9

1

0

High-throughput

0.279

Low

717605

PDIA3
Protein disulfide-isomerase A3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025