Protein: SYMM
Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS)

Gene: SYMM, MARS2
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q96GW9

Gene Ontology (top 5):
GO:0004825 - methionine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006418 - tRNA aminoacylation for protein translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

275347

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

3

High-throughput

0.628

High

532868

CH60
60 kDa heat shock protein, mitochondrial

2

5

High-throughput

0.628

High

1370889

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

2

3

High-throughput

0.611

High

1392407

RM04
Large ribosomal subunit protein uL4m

2

1

High-throughput

0.611

High

273084

CLU
Clustered mitochondria protein homolog

2

2

High-throughput

0.601

High

1162485

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

3

High-throughput

0.584

High

1247880

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

2

0

High-throughput

0.576

High

1392411

SMUF2
E3 ubiquitin-protein ligase SMURF2

2

11

High-throughput

0.574

High

350956

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

4

High-throughput

0.536

High

642107

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

1

High-throughput

0.536

High

869211

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

3

High-throughput

0.536

High

946515

YBEY
Endoribonuclease YbeY

1

2

High-throughput

0.536

High

1238407

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

2

High-throughput

0.536

High

1310309

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

High-throughput

0.536

High

1388983

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

2

High-throughput

0.536

High

1392405

MYL10
Myosin regulatory light chain 10

1

3

High-throughput

0.536

High

1392406

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

4

High-throughput

0.536

High

1392415

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

2

High-throughput

0.536

High

1392417

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

1

0

High-throughput

0.513

High

182722

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.489

High

635478

MAG
Myelin-associated glycoprotein

1

4

High-throughput

0.489

High

842982

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

2

High-throughput

0.489

High

1356082

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

2

High-throughput

0.489

High

530221

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.479

High

185931

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.457

High

422876

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

123163

DX39A
ATP-dependent RNA helicase DDX39A

1

1

High-throughput

0.445

High

135681

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.445

High

321113

PLPHP
Pyridoxal phosphate homeostasis protein

1

1

High-throughput

0.445

High

354377

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

2

High-throughput

0.445

High

360210

GSHR
Glutathione reductase, mitochondrial

1

5

High-throughput

0.445

High

647445

SCP2
Sterol carrier protein 2

1

3

High-throughput

0.445

High

690534

KAD4
Adenylate kinase 4, mitochondrial

1

2

High-throughput

0.445

High

770460

SPRE
Sepiapterin reductase

1

2

High-throughput

0.445

High

851990

EFTS
Elongation factor Ts, mitochondrial

1

3

High-throughput

0.445

High

854906

RECQ1
ATP-dependent DNA helicase Q1

1

3

High-throughput

0.445

High

884558

SYAC
Alanine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.445

High

1092621

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

3

High-throughput

0.445

High

346189

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.437

High

566004

EF2
Elongation factor 2

1

11

High-throughput

0.437

High

589408

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

696207

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.437

High

768888

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

1255056

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1386533

OPTN
Optineurin

1

12

High-throughput

0.437

High

192294

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.426

High

663373

KTHY
Thymidylate kinase

1

0

High-throughput

0.426

High

1187799

AL1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase

1

0

High-throughput

0.426

High

1232851

PTRD1
Putative peptidyl-tRNA hydrolase PTRHD1

1

0

High-throughput

0.426

High

1286658

GLRX5
Glutaredoxin-related protein 5, mitochondrial

1

0

High-throughput

0.426

High

1392410

PPCS
Phosphopantothenate--cysteine ligase

1

0

High-throughput

0.426

High

1392416

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.426

High

226857

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

7

High-throughput

0.407

High

957999

RAB14
Ras-related protein Rab-14

1

2

High-throughput

0.407

High

1061274

RHG01
Rho GTPase-activating protein 1

1

2

High-throughput

0.407

High

1094794

CAF1B
Chromatin assembly factor 1 subunit B

1

4

High-throughput

0.407

High

1349508

LRC20
Leucine-rich repeat-containing protein 20

1

1

High-throughput

0.407

High

1356530

RAB2B
Ras-related protein Rab-2B

1

2

High-throughput

0.407

High

1358771

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

3

High-throughput

0.407

High

1392402

PDLI2
PDZ and LIM domain protein 2

1

1

High-throughput

0.407

High

1392403

PUS7
Pseudouridylate synthase 7 homolog

1

1

High-throughput

0.407

High

1392409

AMPB
Aminopeptidase B

1

2

High-throughput

0.407

High

1392413

XPP1
Xaa-Pro aminopeptidase 1

1

2

High-throughput

0.407

High

1392414

UBQL4
Ubiquilin-4

1

7

High-throughput

0.407

High

1392418

LMCD1
LIM and cysteine-rich domains protein 1

1

1

High-throughput

0.407

High

1392420

SAE1
SUMO-activating enzyme subunit 1

1

1

High-throughput

0.407

High

1392421

UBQL2
Ubiquilin-2

1

3

High-throughput

0.407

High

1392423

SBDS
Ribosome maturation protein SBDS

1

1

High-throughput

0.407

High

1392424

SERC
Phosphoserine aminotransferase

1

1

High-throughput

0.407

High

731815

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

3

0

High-throughput

0.347

High

1309569

F219A
Protein FAM219A

3

0

High-throughput

0.347

High

1325192

HROB
Homologous recombination OB-fold protein

2

0

High-throughput

0.328

High

1205798

GSAML
Germinal center-associated signaling and motility-like protein

1

0

High-throughput

0.279

Low

1260476

MTSS2
Protein MTSS 2

1

0

High-throughput

0.279

Low

1273985

SSX7
Protein SSX7

1

0

High-throughput

0.279

Low

1325171

TAFA2
Chemokine-like protein TAFA-2

1

0

High-throughput

0.279

Low

1392419

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

0

High-throughput

0.279

Low

215444

TPD54
Tumor protein D54

1

0

High-throughput

0.232

Low

249649

SNX3
Sorting nexin-3

1

0

High-throughput

0.232

Low

933044

SNAA
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.232

Low

1391006

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.232

Low

1392404

NIBA2
Protein Niban 2

1

0

High-throughput

0.232

Low

1392408

NAA50
N-alpha-acetyltransferase 50

1

0

High-throughput

0.232

Low

1392412

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

0

High-throughput

0.232

Low

1392422

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025