HitPredict

Interactor 1: PSA2 (P40301)
Proteasome subunit alpha type-2 (PROS-Dm25) (Proteasome 25 kDa subunit)
Gene: Prosalpha2

Interactor 2: PSB4 (Q9VNA5)
Proteasome subunit beta type-4 (Proteasome subunit beta type-7)
Gene: Prosbeta7

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	22036573, 19079254
Identification Methods	affinity chromatography technology, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005839 - proteasome core complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 234 Dm			1 268
+	Sp
		293714 PSA2_SCHPO (3-233): 1.96e-107: 311: 58.20		PSA3_SCHPO (32-268): 2.01e-81: 246: 14.82
+	Hs
		156230 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSA7_HUMAN (33-265): 2.53e-82: 248: 12.55
+	Ce
		1099869 PSA2_CAEEL (4-233): 3.6e-99: 289: 60.35		PSA7_CAEEL (32-266): 3.39e-79: 241: 13.69
+	Hs
		656276 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSMA8_HUMAN (33-265): 1.01e-79: 242: 12.25
+	Hs
		638067 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSA4_HUMAN (32-265): 3.42e-79: 241: 13.33
+	Hs
		656189 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSA6_HUMAN (28-265): 1.4e-78: 239: 17.55
+	Hs
		656150 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSB4_HUMAN (12-268): 4.95e-78: 238: 38.91
+	Hs
		656149 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSA5_HUMAN (33-266): 7.04e-78: 237: 17.96
+	Sp
		675393 PSA5_SCHPO (1-231): 3.4e-100: 293: 32.77		PSB5_SCHPO (24-268): 6.17e-75: 230: 18.70
+	Ce
		1099874 PSA2_CAEEL (4-233): 3.6e-99: 289: 60.35		PBS5_CAEEL (6-266): 1.8e-71: 222: 18.22
+	Hs
		656152 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSB5_HUMAN (15-247): 2.34e-71: 221: 18.03
+	Hs
		656296 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSB7_HUMAN (23-260): 1.37e-69: 217: 19.58
+	Hs
		594455 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSB1_HUMAN (22-248): 5.77e-66: 207: 19.66
+	Hs
		656164 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSB10_HUMAN (26-257): 7.3e-66: 207: 17.67
+	Ph
		223381 PSA_PYRHO (4-231): 1.88e-101: 296: 41.74		PSB1_PYRHO (56-253): 1.1e-62: 197: 26.26
+	Mt
		191406 PSA_METTH (1-233): 1.2e-102: 299: 36.17		PSB_METTH (51-245): 1.16e-30: 115: 20.51
+	Mm
		1154361 PSA_METMP (4-233): 8.01e-99: 290: 34.05		PSB_METMP (54-257): 7.49e-31: 115: 19.51
+	Sp
		293719 PSA2_SCHPO (3-233): 1.96e-107: 311: 58.20		PSB3_SCHPO (56-247): 3.51e-21: 90.2: 20.73
+	Hs
		656174 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PSB2_HUMAN (60-247): 7.94e-21: 89: 20.75
+	Dm
		47610 PSA5_DROME (1-233): 1.55e-97: 286: 30.71		A0AQH0_DROME (50-248): 6.38e-21: 89.8: 16.08