HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: PABP4 (Q13310)
Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
Gene: PABPC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	29884807, 27460707
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~zf-RanBP
Common GO terms	GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 644
+	Hs
		1102042 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		PABP4_HUMAN (1-644): 0: 578: 100.00
+	Hs
		550392 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		1102145 RBM8A_HUMAN (219-366): 3.36e-27: 109: 26.35		PABP4_HUMAN (1-644): 0: 578: 100.00
+	Hs
		550147 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		550522 PPIE_HUMAN (280-514): 2.72e-31: 124: 19.84		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		550546 RBM8A_HUMAN (219-366): 3.36e-27: 109: 26.35		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		550262 PABP4_HUMAN (280-379): 4.84e-13: 73.5: 22.00		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		550097 PABP1_HUMAN (281-379): 1.43e-11: 68.9: 22.22		PABP1_HUMAN (1-644): 0: 533: 74.54
+	Hs
		1102095 PABP4_HUMAN (280-379): 4.84e-13: 73.5: 22.00		PABP3_HUMAN (1-644): 1.78e-170: 502: 68.98
+	Hs
		550311 PABP1_HUMAN (281-379): 1.43e-11: 68.9: 22.22		PAP1L_HUMAN (1-636): 4.05e-161: 477: 63.84
+	Hs
		726754 EWS_HUMAN (3-451): 4.67e-30: 126: 31.05		TIA1_HUMAN (3-172): 3.37e-35: 139: 28.42
+	Hs
		620166 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		NUCL_HUMAN (2-89): 3.35e-20: 97.2: 31.82
+	Hs
		620655 PPIE_HUMAN (280-514): 2.72e-31: 124: 19.84		NUCL_HUMAN (2-89): 3.35e-20: 97.2: 31.82
+	Hs
		550137 PABP1_HUMAN (281-379): 1.43e-11: 68.9: 22.22		TIA1_HUMAN (3-172): 3.37e-35: 139: 28.42
+	Hs
		620676 RBM8A_HUMAN (219-366): 3.36e-27: 109: 26.35		NUCL_HUMAN (2-89): 3.35e-20: 97.2: 31.82
+	Hs
		550114 PABP1_HUMAN (281-379): 1.43e-11: 68.9: 22.22		NUCL_HUMAN (2-89): 3.35e-20: 97.2: 31.82
+	Hs
		1102056 PABP4_HUMAN (280-379): 4.84e-13: 73.5: 22.00		PABP5_HUMAN (4-93): 2.56e-15: 80.3: 23.33
+	Hs
		550407 PABP1_HUMAN (281-379): 1.43e-11: 68.9: 22.22		PABP5_HUMAN (4-93): 2.56e-15: 80.3: 23.33
+	Hs
		506129 PABP4_HUMAN (280-379): 4.84e-13: 73.5: 22.00		PAB4L_HUMAN (290-381): 2.81e-12: 70.6: 24.47