HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: SF3B2 (Q13435)
Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145)
Gene: SF3B2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	29884807, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PSP~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008380 - RNA splicing
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 895
+	Hs
		1105360 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		SF3B2_HUMAN (1-895): 0: 1129: 100.00
+	Hs
		1032942 EWS_HUMAN (3-451): 4.67e-30: 126: 31.05		SF3B2_HUMAN (1-895): 0: 1129: 100.00
+	Hs
		1105441 PPIE_HUMAN (280-514): 2.72e-31: 124: 19.84		SF3B2_HUMAN (1-895): 0: 1129: 100.00
+	Hs
		1105453 RBM8A_HUMAN (219-366): 3.36e-27: 109: 26.35		SF3B2_HUMAN (1-895): 0: 1129: 100.00
+	Hs
		225287 HTSF1_HUMAN (267-372): 6.21e-23: 104: 21.30		SF3B2_HUMAN (1-895): 0: 1129: 100.00
+	Dm
		1484302 Q9W424_DROME (265-407): 2e-18: 88.8: 19.61		Q9VQK7_DROME (278-895): 0: 687: 57.90
+	Sc
		403628 PABP_YEAST (252-381): 1.45e-10: 65.8: 16.92		CUS1_YEAST (326-754): 2.33e-111: 350: 26.77