Protein: CUS1
Cold sensitive U2 snRNA suppressor 1

Gene: CUS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 76
UniProt ID: Q02554

Gene Ontology (top 5):
GO:0000245 - spliceosomal complex assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1037770

HSH49
Protein HSH49

8

6

Small-scale

0.978

High

892776

SF3B1
U2 snRNP component HSH155

9

2

Small-scale

0.971

High

1037753

RSE1
Pre-mRNA-splicing factor RSE1

7

1

Small-scale

0.966

High

1037759

PRP11
Pre-mRNA-splicing factor PRP11

5

1

High-throughput

0.922

High

625120

PRP9
Pre-mRNA-splicing factor PRP9

4

1

High-throughput

0.892

High

826523

IST3
U2 snRNP component IST3

2

1

Small-scale

0.789

High

1037760

NCBP2
Nuclear cap-binding protein subunit 2

2

2

Small-scale

0.754

High

1037761

RU2A
U2 small nuclear ribonucleoprotein A'

7

2

Small-scale

0.744

High

1037762

CWC2
Pre-mRNA-splicing factor CWC2

2

2

High-throughput

0.737

High

817149

RSMB
Small nuclear ribonucleoprotein-associated protein B

6

2

High-throughput

0.730

High

847822

SMD3
Small nuclear ribonucleoprotein Sm D3

5

4

High-throughput

0.714

High

739265

PRP21
Pre-mRNA-splicing factor PRP21

4

1

High-throughput

0.694

High

1037766

CLF1
Pre-mRNA-splicing factor CLF1

4

3

Small-scale

0.692

High

403628

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

High-throughput

0.691

High

933131

RUXF
Small nuclear ribonucleoprotein F

4

1

High-throughput

0.678

High

501744

YSF3
RDS3 complex subunit 10

2

0

Small-scale

0.676

High

1037764

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.665

High

744151

BRR2
Pre-mRNA-splicing helicase BRR2

3

4

High-throughput

0.664

High

1037768

PRP46
Pre-mRNA-splicing factor PRP46

3

2

High-throughput

0.662

High

1037758

RDS3
Pre-mRNA-splicing factor RDS3

3

1

Small-scale

0.656

High

739189

PRP19
Pre-mRNA-processing factor 19

3

3

Small-scale

0.650

High

1036166

SMD1
Small nuclear ribonucleoprotein Sm D1

3

1

High-throughput

0.650

High

1037755

SMD2
Small nuclear ribonucleoprotein Sm D2

3

1

High-throughput

0.650

High

820830

RUXG
Small nuclear ribonucleoprotein G

3

4

High-throughput

0.643

High

757521

NCBP1
Nuclear cap-binding protein complex subunit 1

2

1

High-throughput

0.621

High

863091

CWC26
Pre-mRNA-splicing factor CWC26

3

0

Small-scale

0.620

High

1027982

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

2

High-throughput

0.618

High

1031030

NOP3
Serine/arginine

1

4

High-throughput

0.618

High

751776

PRP8
Pre-mRNA-splicing factor 8

2

1

High-throughput

0.611

High

1037750

CEF1
Pre-mRNA-splicing factor CEF1

2

2

High-throughput

0.601

High

797318

SP381
Pre-mRNA-splicing factor SPP381

2

0

High-throughput

0.595

High

743549

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.586

High

1037748

CUS1
Cold sensitive U2 snRNA suppressor 1

1

0

Small-scale

0.586

High

750293

PRP40
Pre-mRNA-processing protein PRP40

2

3

High-throughput

0.584

High

1037749

CWC21
Pre-mRNA-splicing factor CWC21

2

0

High-throughput

0.576

High

1037754

SN309
Pre-mRNA-splicing factor SNT309

2

0

High-throughput

0.559

High

524896

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.552

High

672069

BUD31
Pre-mRNA-splicing factor BUD31

2

0

Small-scale

0.547

High

722186

XPO1
Exportin-1

1

0

High-throughput

0.513

High

1037757

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.513

High

577574

CYC8
General transcriptional corepressor CYC8

1

1

High-throughput

0.508

High

809396

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

483803

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.486

High

697390

MIG1
Regulatory protein MIG1

1

0

High-throughput

0.486

High

780849

MUD2
Splicing factor MUD2

1

0

Small-scale

0.486

High

811485

XDJ1
DnaJ protein homolog XDJ1

1

0

High-throughput

0.486

High

679989

CDC48
Cell division control protein 48

1

0

High-throughput

0.479

High

628222

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

1

2

High-throughput

0.479

High

638015

PRP5
Pre-mRNA-processing ATP-dependent RNA helicase PRP5

1

2

High-throughput

0.479

High

700136

PRP45
Pre-mRNA-processing protein 45

1

1

High-throughput

0.479

High

780212

SN114
Pre-mRNA-splicing factor SNU114

1

2

High-throughput

0.479

High

826544

MSL1
U2 small nuclear ribonucleoprotein B''

1

5

High-throughput

0.479

High

829952

PRP17
Pre-mRNA-processing factor 17

1

3

High-throughput

0.479

High

1037752

SYF1
Pre-mRNA-splicing factor SYF1

1

3

High-throughput

0.479

High

1037767

RUXE
Small nuclear ribonucleoprotein E

1

1

High-throughput

0.479

High

1037756

CORO
Coronin-like protein

1

1

High-throughput

0.470

High

513750

RL2A
Large ribosomal subunit protein uL2A

1

0

High-throughput

0.458

High

638076

ISY1
Pre-mRNA-splicing factor ISY1

1

0

High-throughput

0.458

High

702273

YJU2
Splicing factor YJU2

1

0

High-throughput

0.458

High

707951

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

781980

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.458

High

796456

SLT11
Pre-mRNA-splicing factor SLT11

1

0

High-throughput

0.458

High

919214

SYF2
Pre-mRNA-splicing factor SYF2

1

0

High-throughput

0.458

High

1031759

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.458

High

1037751

CWC15
Pre-mRNA-splicing factor CWC15

1

0

High-throughput

0.458

High

1037763

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

1037769

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

0

Small-scale

0.458

High

481735

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.445

High

527473

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

545964

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

945344

LSM3
LSM complex subunit LSM3

1

6

High-throughput

0.445

High

590704

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

1037765

CRM2
Homeostatic regulator of DAG

1

0

High-throughput

0.269

Low

394838

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

797781

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025