HitPredict

Interactor 1: RFC5 (P40937)
Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)
Gene: RFC5

Interactor 2: ATAD5 (Q96QE3)
ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein)
Gene: ATAD5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	31160570, 28514442, 24981860, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA~AAA, AAA~Rep_fac_C
Common GO terms	GO:0003677 - DNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0016887 - ATP hydrolysis activity GO:0031391 - Elg1 RFC-like complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 340 Hs			1 1844
+	Hs
		722022 RFC4_HUMAN (1-331): 9.47e-89: 272: 36.77		ATAD5_HUMAN (1-1844): 0: 1306: 100.00
+	Hs
		722179 RFC5_HUMAN (1-340): 5.53e-102: 305: 100.00		RFC1_HUMAN (433-1276): 4.59e-53: 207: 14.77
+	Hs
		721934 RFC4_HUMAN (1-331): 9.47e-89: 272: 36.77		RFC1_HUMAN (433-1276): 4.59e-53: 207: 14.77
+	Hs
		722068 RFC2_HUMAN (2-331): 2.97e-86: 265: 35.35		RFC1_HUMAN (433-1276): 4.59e-53: 207: 14.77
+	Dm
		725336 Q9VKW3_DROME (11-339): 2.95e-91: 277: 60.30		RFC1_DROME (609-1293): 8.06e-48: 189: 14.67
+	Hs
		777901 RFC5_HUMAN (1-340): 5.53e-102: 305: 100.00		CTF18_HUMAN (998-1222): 2.17e-34: 146: 17.57
+	Sp
		144039 RFC3_SCHPO (17-338): 1.43e-88: 271: 52.48		ELG1_SCHPO (730-1251): 1.44e-43: 175: 13.41
+	Dm
		725318 RFC2_DROME (6-334): 4.69e-83: 256: 34.85		RFC1_DROME (609-1293): 8.06e-48: 189: 14.67
+	Dm
		725339 Q9VX15_DROME (2-334): 2.91e-79: 247: 34.01		RFC1_DROME (609-1293): 8.06e-48: 189: 14.67
+	Hs
		722015 RFC4_HUMAN (1-331): 9.47e-89: 272: 36.77		CTF18_HUMAN (998-1222): 2.17e-34: 146: 17.57
+	At
		1275801 RFC5_ARATH (13-340): 2.2e-82: 256: 55.92		RFC4_ARATH (1085-1330): 7e-42: 159: 14.79
+	Hs
		722134 RFC2_HUMAN (2-331): 2.97e-86: 265: 35.35		CTF18_HUMAN (998-1222): 2.17e-34: 146: 17.57
+	Sc
		751278 RFC3_YEAST (9-334): 2.33e-83: 257: 49.10		CTF18_YEAST (1020-1501): 1.12e-36: 152: 16.03
+	Hs
		777860 RFC5_HUMAN (1-340): 5.53e-102: 305: 100.00		MDC1_HUMAN (10-849): 1.46e-20: 101: 8.33
+	Sc
		751260 RFC3_YEAST (9-334): 2.33e-83: 257: 49.10		RFC1_YEAST (711-1292): 1.4e-34: 146: 14.55
+	Sc
		772422 RFC2_YEAST (2-331): 2.73e-79: 247: 33.43		CTF18_YEAST (1020-1501): 1.12e-36: 152: 16.03
+	Sc
		751312 RFC2_YEAST (2-331): 2.73e-79: 247: 33.43		RFC1_YEAST (711-1292): 1.4e-34: 146: 14.55
+	Zm
		75542 B4FJC2_MAIZE (18-340): 1.45e-85: 264: 56.75		B4FQT5_MAIZE (1085-1380): 3.28e-31: 128: 14.52
+	Hs
		721989 RFC4_HUMAN (1-331): 9.47e-89: 272: 36.77		MDC1_HUMAN (10-849): 1.46e-20: 101: 8.33
+	Hs
		722109 RFC2_HUMAN (2-331): 2.97e-86: 265: 35.35		MDC1_HUMAN (10-849): 1.46e-20: 101: 8.33