HitPredict

Interactor 1: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Interactor 2: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	10753943, 19262695
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0032715 - negative regulation of interleukin-6 production
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 450 Hs			1 418
+	Hs
		522859 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		433291 YES_HUMAN (12-442): 5.99e-170: 490: 37.30		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Mm
		980969 YES_MOUSE (12-442): 6.97e-170: 489: 37.08		ARRB1_MOUSE (1-418): 0: 703: 98.57
+	Mm
		403452 SRC_MOUSE (12-442): 1.93e-169: 488: 39.55		ARRB1_MOUSE (1-418): 0: 703: 98.57
+	Hs
		685825 CSK_HUMAN (1-450): 0: 543: 100.00		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Hs
		522813 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Mm
		403455 SRC_MOUSE (12-442): 1.93e-169: 488: 39.55		ARRB2_MOUSE (1-407): 0: 615: 75.00