HitPredict

Interactor 1: M3K8 (P41279)
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)
Gene: MAP3K8

Interactor 2: REL (Q04864)
Proto-oncogene c-Rel
Gene: REL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	14743216
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 467 Hs			1 619
+	Hs
		682168 AKT2_HUMAN (31-438): 7.59e-137: 404: 15.46		REL_HUMAN (1-619): 0: 692: 100.00
+	Hs
		783318 M3K8_HUMAN (1-467): 9.62e-140: 411: 100.00		TF65_HUMAN (2-576): 4.74e-158: 466: 37.89
+	Mm
		638451 M3K8_MOUSE (1-467): 1.09e-138: 408: 93.36		NFKB1_MOUSE (1-414): 1.82e-152: 465: 33.56
+	Rn
		812706 AKT1_RAT (43-466): 3.95e-134: 397: 15.64		NFKB1_RAT (3-414): 6.43e-153: 467: 34.60
+	Hs
		587460 M3K8_HUMAN (1-467): 9.62e-140: 411: 100.00		NFKB1_HUMAN (1-375): 2e-145: 447: 37.47
+	Hs
		783315 M3K8_HUMAN (1-467): 9.62e-140: 411: 100.00		NFKB2_HUMAN (2-385): 2.1e-133: 414: 34.88
+	Hs
		981702 M3K14_HUMAN (107-382): 8.18e-30: 125: 30.66		REL_HUMAN (1-619): 0: 692: 100.00
+	Hs
		964521 M3K14_HUMAN (107-382): 8.18e-30: 125: 30.66		RELB_HUMAN (2-479): 1.52e-143: 430: 35.04
+	Hs
		961425 M3K14_HUMAN (107-382): 8.18e-30: 125: 30.66		NFKB2_HUMAN (2-385): 2.1e-133: 414: 34.88
+	Rn
		1144345 AKT3_RAT (80-466): 6.16e-133: 394: 16.96		SC31A_RAT (270-590): 8.85e-32: 133: 11.18