HitPredict

Interactor 1: EZ (P42124)
Histone-lysine N-methyltransferase E(z) (EC 2.1.1.356) (Lysine N-methyltransferase 6) (Protein enhancer of zeste)
Gene: E(z)

Interactor 2: ESC (Q24338)
Polycomb protein esc (Protein extra sex combs)
Gene: ESC

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 11124122, 26063573, 11571280, 12408864, 15175158, 15776017, 9693151, 18048023, 19767730, 18276122, 9566901, 12697833, 10757791, 11581156, 16618800, 24100017, 29242288, 29070704, 25242320, 17210640 and 5 others

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Identification Methods affinity chromatography technology, two hybrid, pull down, biochemical, molecular sieving, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, coimmunoprecipitation, experimental interaction detection
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains SET~WD40
Common GO terms GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0009948 - anterior/posterior axis specification
GO:0031507 - heterochromatin formation
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 760
Dm

1 425
+ Dm
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+ Mm
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+ Mm
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+ Mm
+ Zm
+ Hs
+ At
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+ Hs
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+ Mm
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024