Protein: MCE1
mRNA-capping enzyme subunit alpha (GTP--RNA guanylyltransferase) (GTase) (mRNA guanylyltransferase) (EC 2.7.7.50)

Gene: MCE1, CEG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 60
UniProt ID: Q01159

Gene Ontology (top 5):
GO:0004484 - mRNA guanylyltransferase activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding
GO:0005634 - nucleus
GO:0006370 - 7-methylguanosine mRNA capping

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

402087

RPB1
DNA-directed RNA polymerase II subunit RPB1

9

2

Small-scale

0.967

High

148880

CET1
mRNA-capping enzyme subunit beta

17

0

Small-scale

0.938

High

632106

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

1

Small-scale

0.754

High

757343

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

1

Small-scale

0.754

High

594516

RPB3
DNA-directed RNA polymerase II subunit RPB3

6

1

Small-scale

0.721

High

481727

HSP73
Heat shock protein SSA3

2

2

High-throughput

0.621

High

645769

HSP74
Heat shock protein SSA4

2

2

High-throughput

0.621

High

448996

TOP2
DNA topoisomerase 2

2

0

High-throughput

0.595

High

805624

LSM12
Protein LSM12

2

0

High-throughput

0.595

High

814022

IF2P
Eukaryotic translation initiation factor 5B

2

0

High-throughput

0.595

High

694620

SPT5
Transcription elongation factor SPT5

2

2

High-throughput

0.584

High

382284

H4
Histone H4

2

0

High-throughput

0.563

High

639050

VPS1
Vacuolar protein sorting-associated protein 1

2

0

High-throughput

0.563

High

917455

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

0

High-throughput

0.563

High

1018315

CTR9
RNA polymerase-associated protein CTR9

2

0

High-throughput

0.563

High

1029636

CLU
Clustered mitochondria protein 1

2

2

High-throughput

0.537

High

454124

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.513

High

824993

FKH1
Fork head protein homolog 1

1

0

High-throughput

0.513

High

470574

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.479

High

632202

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

632366

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

645083

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.479

High

661186

SPT6
Transcription elongation factor SPT6

1

1

High-throughput

0.479

High

699968

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

748304

SPT4
Transcription elongation factor SPT4

1

1

High-throughput

0.479

High

806944

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

1

High-throughput

0.479

High

863942

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

1

High-throughput

0.479

High

598902

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

0

High-throughput

0.458

High

607782

HXKG
Glucokinase-1

1

0

High-throughput

0.458

High

632283

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

707921

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

808884

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

836533

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.458

High

909758

YPT32
GTP-binding protein YPT32/YPT11

1

0

High-throughput

0.458

High

918021

PNC1
Nicotinamidase

1

0

High-throughput

0.458

High

1029637

IWS1
Transcription factor SPN1

1

0

High-throughput

0.458

High

1029638

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

1029640

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

527444

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

531851

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.445

High

819526

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

885061

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

919482

CRH1
Congo red hypersensitive protein 1 [Includes: Chitinase CRH1

1

1

High-throughput

0.437

High

394827

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

739724

SPT16
FACT complex subunit SPT16

3

0

High-throughput

0.345

High

738419

EIF3C
Eukaryotic translation initiation factor 3 subunit C

2

0

High-throughput

0.324

High

585346

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.307

High

737484

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

2

0

High-throughput

0.307

High

796613

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

0

High-throughput

0.307

High

815839

BEM2
GTPase-activating protein BEM2/IPL2

2

0

High-throughput

0.307

High

1029639

AVO1
Target of rapamycin complex 2 subunit AVO1

2

0

High-throughput

0.307

High

672707

BPH1
Beige protein homolog 1

1

0

High-throughput

0.249

Low

673338

TRX3
Thioredoxin-3, mitochondrial

1

0

High-throughput

0.249

Low

677527

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

871855

SEC16
COPII coat assembly protein SEC16

1

0

High-throughput

0.249

Low

916400

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.249

Low

917241

AIM14
Probable metalloreductase AIM14

1

0

High-throughput

0.249

Low

918594

TWF1
Twinfilin-1

1

0

High-throughput

0.249

Low

712647

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.232

Low

1029641

RL7B
Large ribosomal subunit protein uL30B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025