HitPredict

Interactor 1: EZ (P42124)
Histone-lysine N-methyltransferase E(z) (EC 2.1.1.356) (Lysine N-methyltransferase 6) (Protein enhancer of zeste)
Gene: E(z)

Interactor 2: Q9VKD5 (Q9VKD5)
Escl, isoform A (Escl, isoform C) (SD11903p)
Gene: escl

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	18048023, 18276122
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0035098 - ESC/E(Z) complex GO:0140718 - facultative heterochromatin formation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 760 Dm			1 462
+	Dm
		785633 EZ_DROME (1-760): 0: 799: 100.00		Q95SW6_DROME (273-462): 1.33e-103: 308: 100.00
+	Dm
		785624 EZ_DROME (1-760): 0: 799: 100.00		ESC_DROME (9-243): 2.99e-09: 60.7: 9.60
+	Hs
		1080207 EZH2_HUMAN (3-759): 0: 658: 51.64		FBXW7_HUMAN (2-280): 4.61e-41: 157: 11.37
+	Hs
		863447 EZH2_HUMAN (3-759): 0: 658: 51.64		COPA_HUMAN (327-462): 1.18e-18: 91.1: 12.32
+	Mm
		936654 EZH1_MOUSE (3-759): 0: 675: 50.00		EED_MOUSE (22-285): 6.27e-10: 63: 8.31
+	Hs
		268202 EZH1_HUMAN (3-760): 0: 667: 49.43		EED_HUMAN (22-285): 6.27e-10: 63: 8.31
+	Mm
		1110537 Q6AXH7_MOUSE (3-759): 0: 653: 51.90		Q3TAU7_MOUSE (182-289): 1.6e-13: 69: 21.30
+	Mm
		1142289 EZH2_MOUSE (3-759): 0: 658: 51.51		EED_MOUSE (22-285): 6.27e-10: 63: 8.31
+	Hs
		268116 EZH2_HUMAN (3-759): 0: 658: 51.64		EED_HUMAN (22-285): 6.27e-10: 63: 8.31
+	Mm
		1149787 Q6AXH7_MOUSE (3-759): 0: 653: 51.90		EED_MOUSE (22-285): 6.27e-10: 63: 8.31
+	At
		955880 CLF_ARATH (224-750): 2.38e-117: 377: 26.59		FIE_ARATH (91-462): 2.23e-73: 237: 38.34
+	Zm
		35725 A0A1D6M742_MAIZE (134-758): 1.95e-171: 511: 14.80		A0A1D6LQJ4_MAIZE (11-195): 3.39e-10: 63: 7.41
+	At
		249569 MEDEA_ARATH (274-746): 2.3e-103: 334: 32.09		FIE_ARATH (91-462): 2.23e-73: 237: 38.34
+	At
		1339603 EZA1_ARATH (331-750): 3.55e-97: 322: 31.42		FIE_ARATH (91-462): 2.23e-73: 237: 38.34
+	Hs
		203735 SUV91_HUMAN (438-760): 1.31e-87: 284: 22.04		DAW1_HUMAN (3-239): 1.29e-44: 162: 11.72
+	Hs
		1317584 SETD2_HUMAN (448-760): 2.85e-68: 247: 21.70		NLE1_HUMAN (2-352): 6.18e-55: 192: 11.33
+	Hs
		1288291 SETD2_HUMAN (448-760): 2.85e-68: 247: 21.70		SNR40_HUMAN (357-462): 5.65e-14: 74.9: 14.15
+	Mm
		1207353 NSD2_MOUSE (477-760): 2.41e-67: 244: 21.43		EED_MOUSE (22-285): 6.27e-10: 63: 8.31
+	Mm
		1265660 EHMT2_MOUSE (505-757): 4.59e-67: 243: 24.91		EED_MOUSE (22-285): 6.27e-10: 63: 8.31
+	Hs
		268290 EHMT1_HUMAN (507-757): 1.81e-66: 241: 23.66		EED_HUMAN (22-285): 6.27e-10: 63: 8.31