Protein: RPA1
DNA-directed RNA polymerase I subunit RPA190 (EC 2.7.7.6) (DNA-directed RNA polymerase I 190 kDa polypeptide) (A190) (DNA-directed RNA polymerase I largest subunit)

Gene: RPA1, RPA190
Organism: Saccharomyces cerevisiae S288C
Interactions: 159
UniProt ID: P10964

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0005736 - RNA polymerase I complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534215

RPA2
DNA-directed RNA polymerase I subunit RPA135

17

20

Small-scale

0.986

High

534211

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

13

15

Small-scale

0.981

High

534276

RPA43
DNA-directed RNA polymerase I subunit RPA43

12

1

Small-scale

0.977

High

458987

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

10

19

Small-scale

0.976

High

534212

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

9

10

Small-scale

0.972

High

534297

RPA49
DNA-directed RNA polymerase I subunit RPA49

9

3

Small-scale

0.968

High

534235

RPA12
DNA-directed RNA polymerase I subunit RPA12

8

20

Small-scale

0.963

High

534213

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

6

10

Small-scale

0.943

High

534225

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

5

11

Small-scale

0.919

High

534251

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

5

2

Small-scale

0.908

High

534224

SPT5
Transcription elongation factor SPT5

4

3

Small-scale

0.886

High

534270

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

4

9

Small-scale

0.881

High

534282

RPA14
DNA-directed RNA polymerase I subunit RPA14

5

0

Small-scale

0.865

High

534309

RRP5
rRNA biogenesis protein RRP5

3

5

Small-scale

0.805

High

534200

RPA1
DNA-directed RNA polymerase I subunit RPA190

2

11

Small-scale

0.759

High

534208

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

19

Small-scale

0.754

High

534216

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

6

11

Small-scale

0.730

High

534277

RPA34
DNA-directed RNA polymerase I subunit RPA34

7

0

Small-scale

0.706

High

534278

NET1
Nucleolar protein NET1

4

1

Small-scale

0.691

High

534315

RIX7
Ribosome biogenesis ATPase RIX7

3

4

High-throughput

0.657

High

534201

SSB1
Ribosome-associated molecular chaperone SSB1

3

7

High-throughput

0.650

High

534292

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

5

Small-scale

0.624

High

534210

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

8

Small-scale

0.618

High

534227

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.618

High

534231

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.618

High

534237

STH1
Nuclear protein STH1/NPS1

1

9

Small-scale

0.618

High

534302

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.618

High

534312

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

10

Small-scale

0.618

High

522852

HSP71
Heat shock protein SSA1

3

7

High-throughput

0.611

High

525743

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.601

High

534250

DOA1
Protein DOA1

2

7

High-throughput

0.588

High

149538

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.586

High

444730

SIR2
NAD-dependent histone deacetylase SIR2

2

5

Small-scale

0.584

High

534253

GBLP
Small ribosomal subunit protein RACK1

2

8

Small-scale

0.584

High

534271

DSN1
Kinetochore-associated protein DSN1

2

2

High-throughput

0.584

High

534275

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

534296

CDC14
Tyrosine-protein phosphatase CDC14

2

5

Small-scale

0.584

High

534268

SSB2
Ribosome-associated molecular chaperone SSB2

2

7

High-throughput

0.552

High

534206

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.536

High

534209

CSK22
Casein kinase II subunit alpha'

1

10

High-throughput

0.536

High

534220

SGF29
SAGA complex subunit SGF29

1

1

High-throughput

0.536

High

534247

SPT7
SAGA complex subunit SPT7

1

14

High-throughput

0.536

High

534254

CHK1
Serine/threonine-protein kinase CHK1

1

1

High-throughput

0.536

High

534286

FMP48
Probable serine/threonine-protein kinase FMP48

1

2

High-throughput

0.536

High

534298

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

5

High-throughput

0.536

High

534317

RBX1
RING-box protein HRT1

1

1

High-throughput

0.536

High

534274

BUD27
Bud site selection protein 27

2

2

Small-scale

0.533

High

534226

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.518

High

433395

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.517

High

534218

SIS1
Protein SIS1

1

4

High-throughput

0.515

High

534217

CG23
G2/mitotic-specific cyclin-3

1

0

High-throughput

0.513

High

534272

YCH1
CDC25-like phosphatase YCH1

1

0

High-throughput

0.513

High

534284

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.513

High

368565

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.500

High

534221

CDC48
Cell division control protein 48

1

4

High-throughput

0.500

High

534316

PSR2
Probable phosphatase PSR2

1

7

High-throughput

0.489

High

534283

PFD6
Prefoldin subunit 6

1

3

High-throughput

0.481

High

381818

H4
Histone H4

1

4

High-throughput

0.479

High

403321

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

2

Small-scale

0.479

High

419564

H2A2
Histone H2A.2

1

6

High-throughput

0.479

High

434749

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

436299

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

3

High-throughput

0.479

High

441654

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

512207

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

514404

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

534203

DPOLA
DNA polymerase alpha catalytic subunit A

1

1

Small-scale

0.479

High

534219

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

534222

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.479

High

534223

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

534228

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

534229

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

2

Small-scale

0.479

High

534230

HS104
Heat shock protein 104

1

7

High-throughput

0.479

High

534238

PP12
Serine/threonine-protein phosphatase PP1-2

1

7

Small-scale

0.479

High

534239

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

534241

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

534243

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

534259

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

534262

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

534269

ATAD2
ATPase histone chaperone YTA7

1

7

High-throughput

0.479

High

534290

THO2
THO complex subunit 2

1

1

Small-scale

0.479

High

534293

H3
Histone H3

1

6

High-throughput

0.479

High

534294

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.479

High

534295

SEN1
Helicase SEN1

1

5

Small-scale

0.479

High

534301

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.479

High

534304

ESP1
Separin

1

1

High-throughput

0.479

High

534305

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.479

High

534306

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

534308

POB3
FACT complex subunit POB3

1

4

High-throughput

0.479

High

534311

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

534314

IWR1
RNA polymerase II nuclear localization protein IWR1

1

2

High-throughput

0.479

High

534318

SGO1
Shugoshin

1

1

High-throughput

0.479

High

534321

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

534325

SMT3
Ubiquitin-like protein SMT3

1

2

High-throughput

0.479

High

534327

NOP58
Nucleolar protein 58

1

3

High-throughput

0.479

High

534242

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

534257

FL2D
Protein MUM2

1

0

High-throughput

0.460

High

435720

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

534233

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.458

High

534244

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.458

High

534252

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

534256

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.458

High

534273

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

534280

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

534285

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

534288

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

534289

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.458

High

534291

TR112
Multifunctional methyltransferase subunit TRM112

1

0

Small-scale

0.458

High

534303

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.458

High

534307

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

534310

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

Small-scale

0.458

High

534319

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

534322

PSH1
RING finger protein PSH1

1

0

High-throughput

0.458

High

534323

MAK21
Ribosome biogenesis protein MAK21

1

0

High-throughput

0.458

High

534324

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

392104

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

417010

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.445

High

509357

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.445

High

534204

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.445

High

534205

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.445

High

534245

HSP78
Heat shock protein 78, mitochondrial

1

9

High-throughput

0.445

High

534260

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

534263

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

1

Small-scale

0.445

High

534264

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.445

High

534265

CAJ1
Protein CAJ1

1

3

High-throughput

0.445

High

477494

MYO1
Myosin-1

1

1

Small-scale

0.437

High

502794

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

515032

RL19B
Large ribosomal subunit protein eL19

1

2

High-throughput

0.437

High

534202

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

534236

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.437

High

534240

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

534246

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

534248

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

534258

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

534266

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

534279

GPN1
GPN-loop GTPase 1

1

9

Small-scale

0.437

High

534299

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

534313

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

534320

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

485988

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

534214

REB1
DNA-binding protein REB1

1

0

Small-scale

0.426

High

534249

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.426

High

534300

UBC7
Ubiquitin-conjugating enzyme E2 7

1

5

High-throughput

0.417

High

534207

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.407

High

534234

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

High-throughput

0.407

High

534267

PFD2
Prefoldin subunit 2

1

3

High-throughput

0.407

High

534326

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

405005

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

94527

STE2
Pheromone alpha factor receptor

1

0

High-throughput

0.251

Low

534232

SMY1
Kinesin-related protein SMY1

1

0

High-throughput

0.251

Low

383466

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

409887

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

454818

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503992

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

512767

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

534261

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.249

Low

534281

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

534287

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

534255

SEA4
SEH-associated protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025