Protein: RPC1
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (RNA polymerase III subunit C160)

Gene: RPC1, RPO31
Organism: Saccharomyces cerevisiae S288C
Interactions: 90
UniProt ID: P04051

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005666 - RNA polymerase III complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

402193

RPC2
DNA-directed RNA polymerase III subunit RPC2

12

20

Small-scale

0.977

High

402201

RPC3
DNA-directed RNA polymerase III subunit RPC3

11

3

Small-scale

0.977

High

402172

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

9

19

Small-scale

0.971

High

402224

MAF1
Repressor of RNA polymerase III transcription MAF1

9

1

Small-scale

0.970

High

402207

RPC6
DNA-directed RNA polymerase III subunit RPC6

7

1

Small-scale

0.962

High

402188

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

7

15

Small-scale

0.960

High

402210

RPC8
DNA-directed RNA polymerase III subunit RPC8

5

12

High-throughput

0.930

High

402189

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

5

10

Small-scale

0.922

High

402198

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

5

11

Small-scale

0.922

High

402190

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

5

10

Small-scale

0.921

High

402241

RPC10
DNA-directed RNA polymerase III subunit RPC10

4

20

Small-scale

0.892

High

402229

RPC9
DNA-directed RNA polymerase III subunit RPC9

5

0

High-throughput

0.875

High

402187

RPC7
DNA-directed RNA polymerase III subunit RPC7

4

0

Small-scale

0.846

High

402200

TF3B
Transcription factor IIIB 70 kDa subunit

3

5

Small-scale

0.827

High

402186

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

19

Small-scale

0.754

High

402204

STH1
Nuclear protein STH1/NPS1

2

9

Small-scale

0.754

High

402213

RPC5
DNA-directed RNA polymerase III subunit RPC5

6

3

Small-scale

0.730

High

402195

RPC4
DNA-directed RNA polymerase III subunit RPC4

8

0

Small-scale

0.715

High

402166

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

11

High-throughput

0.665

High

402182

ALF
Fructose-bisphosphate aldolase

3

1

Small-scale

0.662

High

402197

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

20

Small-scale

0.656

High

402191

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

3

11

Small-scale

0.650

High

381340

H2B2
Histone H2B.2

3

11

High-throughput

0.643

High

402226

BUD27
Bud site selection protein 27

3

2

Small-scale

0.640

High

402227

RSC8
Chromatin structure-remodeling complex protein RSC8

2

4

High-throughput

0.621

High

401793

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

11

High-throughput

0.618

High

402199

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.618

High

402220

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

9

High-throughput

0.618

High

380905

H2B1
Histone H2B.1

2

11

High-throughput

0.611

High

402168

H2A1
Histone H2A.1

2

6

High-throughput

0.611

High

402228

TFC5
Transcription factor TFIIIB component B''

2

1

High-throughput

0.601

High

402178

NHP6B
Non-histone chromosomal protein 6B

2

7

High-throughput

0.588

High

402212

DOA1
Protein DOA1

2

7

High-throughput

0.588

High

402214

GBLP
Small ribosomal subunit protein RACK1

2

8

High-throughput

0.588

High

402240

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

2

0

High-throughput

0.585

High

402169

H2A2
Histone H2A.2

2

6

High-throughput

0.584

High

402223

DSN1
Kinetochore-associated protein DSN1

2

2

High-throughput

0.584

High

402243

IWR1
RNA polymerase II nuclear localization protein IWR1

2

2

Small-scale

0.584

High

402176

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.552

High

402183

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.536

High

402196

SGF29
SAGA complex subunit SGF29

1

1

High-throughput

0.536

High

402238

ADA2
SAGA complex subunit ADA2

1

4

High-throughput

0.536

High

402171

SIR2
NAD-dependent histone deacetylase SIR2

1

5

High-throughput

0.515

High

402244

RRP44
Exosome complex exonuclease DIS3

1

3

High-throughput

0.515

High

402173

SWI5
Transcriptional factor SWI5

1

0

High-throughput

0.513

High

381765

H4
Histone H4

1

4

High-throughput

0.479

High

402174

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.479

High

402179

TBP
TATA-box-binding protein

1

4

High-throughput

0.479

High

402192

HSP74
Heat shock protein SSA4

1

7

Small-scale

0.479

High

402194

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

402205

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

402208

HSP78
Heat shock protein 78, mitochondrial

1

9

High-throughput

0.479

High

402211

CENPA
Histone H3-like centromeric protein CSE4

1

6

High-throughput

0.479

High

402216

SPP41
Protein SPP41

1

1

High-throughput

0.479

High

402217

NAB3
Nuclear polyadenylated RNA-binding protein 3

1

1

Small-scale

0.479

High

402219

ATAD2
ATPase histone chaperone YTA7

1

7

High-throughput

0.479

High

402222

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

402234

NRD1
Protein NRD1

1

3

Small-scale

0.479

High

402235

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

402236

H3
Histone H3

1

6

High-throughput

0.479

High

402237

SEN1
Helicase SEN1

1

5

Small-scale

0.479

High

402247

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

402249

CMR1
DNA damage-binding protein CMR1

1

4

High-throughput

0.479

High

402221

6P21
6-phosphofructo-2-kinase 1

1

2

High-throughput

0.470

High

402202

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

Small-scale

0.458

High

402215

YHS7
Uncharacterized protein YHR127W

1

0

High-throughput

0.458

High

402246

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

394075

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

402167

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

2

High-throughput

0.445

High

402175

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

402177

NHP6A
Non-histone chromosomal protein 6A

1

7

High-throughput

0.445

High

402203

HSP7F
Heat shock protein homolog SSE1

1

9

High-throughput

0.445

High

402209

IXR1
Intrastrand cross-link recognition protein

1

8

High-throughput

0.445

High

402218

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

402232

DPH4
Diphthamide biosynthesis protein 4

1

2

High-throughput

0.445

High

402233

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.445

High

402231

GPN1
GPN-loop GTPase 1

1

9

Small-scale

0.437

High

402242

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

402248

DBP10
ATP-dependent RNA helicase DBP10

1

7

High-throughput

0.437

High

402181

ABF1
ARS-binding factor 1

1

0

High-throughput

0.426

High

402245

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.426

High

402170

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.407

High

402180

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.407

High

402185

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.407

High

402206

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.407

High

402225

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

402184

ABP1
Actin-binding protein

1

0

High-throughput

0.282

High

402230

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.249

Low

402239

PIR1
Cell wall mannoprotein PIR1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025