HitPredict

Interactor 1: GRIA3 (P42263)
Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3)
Gene: GRIA3

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16990550
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030666 - endocytic vesicle membrane GO:0032281 - AMPA glutamate receptor complex GO:0043197 - dendritic spine GO:0098839 - postsynaptic density membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Hs			1 724
+	Mm
		1143566 GRIA3_MOUSE (7-894): 0: 934: 98.54		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		786726 GRIA2_HUMAN (9-894): 0: 865: 71.35		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		620965 GRIA2_MOUSE (9-894): 0: 863: 71.35		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Mm
		1143565 GRIA4_MOUSE (9-874): 0: 855: 73.47		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Rn
		585138 GRIA1_RAT (13-878): 0: 847: 68.20		DLG4_RAT (1-724): 0: 668: 99.86
+	Mm
		620892 GRIA1_MOUSE (13-878): 0: 844: 67.28		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		942335 GRIK2_HUMAN (6-883): 0: 778: 38.57		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Rn
		677766 GRIK2_RAT (13-883): 0: 775: 38.81		DLG4_RAT (1-724): 0: 668: 99.86
+	Mm
		761217 GRIK2_MOUSE (13-883): 0: 775: 38.81		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Mm
		620881 GRIA1_MOUSE (13-878): 0: 844: 67.28		DLG3_MOUSE (20-724): 0: 583: 64.08
+	Hs
		761199 GRIK1_HUMAN (1-854): 0: 760: 37.91		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Hs
		942350 GRIK5_HUMAN (15-860): 0: 667: 35.24		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		1142982 GRIK5_MOUSE (15-860): 0: 665: 35.12		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Rn
		585186 GRIA2_RAT (9-894): 0: 862: 71.35		MPP4_RAT (64-203): 5.72e-17: 85.9: 15.86
+	Hs
		786696 GRIA1_HUMAN (13-878): 0: 852: 68.20		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Rn
		585151 GRIA1_RAT (13-878): 0: 847: 68.20		DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97
+	Mm
		620904 GRIA1_MOUSE (13-878): 0: 844: 67.28		DLG2_MOUSE (225-474): 1.48e-18: 92.5: 21.09
+	Hs
		1021483 GRIK2_HUMAN (6-883): 0: 778: 38.57		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		1022366 GRIK2_HUMAN (6-883): 0: 778: 38.57		DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58
+	Hs
		1081918 GRIK5_HUMAN (15-860): 0: 667: 35.24		DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58