Protein: GRB2
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)

Gene: GRB2
Organism: Mus musculus
Interactions: 109
UniProt ID: Q60631

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005091 - guanyl-nucleotide exchange factor adaptor activity
GO:0005154 - epidermal growth factor receptor binding
GO:0005168 - neurotrophin TRKA receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1022218

SHC1
SHC-transforming protein 1

21

20

Small-scale

0.986

High

1030069

EGFR
Epidermal growth factor receptor

9

20

Small-scale

0.970

High

1221262

GAB1
GRB2-associated-binding protein 1

6

20

Small-scale

0.930

High

1221225

SOS1
Son of sevenless homolog 1

4

20

Small-scale

0.887

High

686966

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.834

High

767017

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

20

Small-scale

0.827

High

1036602

SOS2
Son of sevenless homolog 2

3

20

Small-scale

0.812

High

611452

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

2

20

Small-scale

0.799

High

107220

F8VQL0
Hepatocyte growth factor receptor

2

20

Small-scale

0.768

High

1039132

TIE2
Angiopoietin-1 receptor

1

20

Small-scale

0.766

High

1221218

LCP2
Lymphocyte cytosolic protein 2

2

20

Small-scale

0.755

High

651529

CBL
E3 ubiquitin-protein ligase CBL

8

20

Small-scale

0.744

High

431458

KIT
Mast/stem cell growth factor receptor Kit

2

20

Small-scale

0.743

High

1221223

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

17

Small-scale

0.737

High

810547

DYN2
Dynamin-2

2

20

Small-scale

0.726

High

431952

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.724

High

1221256

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

20

Small-scale

0.724

High

1191823

Q3ZB59
Growth factor receptor bound protein 2-associated protein 2

2

20

Small-scale

0.721

High

1221221

SNTA1
Alpha-1-syntrophin

1

20

Small-scale

0.716

High

757455

FAK1
Focal adhesion kinase 1

2

20

Small-scale

0.695

High

947403

CPNE2
Copine-2

1

4

High-throughput

0.691

High

1021481

DOK1
Docking protein 1

1

20

High-throughput

0.691

High

1190095

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

6

High-throughput

0.691

High

1221217

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

3

20

Small-scale

0.655

High

1189725

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

15

High-throughput

0.646

High

770697

CD22
B-cell receptor CD22

2

20

Small-scale

0.634

High

236831

LAT
Linker for activation of T-cells family member 1

3

9

Small-scale

0.624

High

1221241

FRS2
Fibroblast growth factor receptor substrate 2

3

20

Small-scale

0.624

High

420096

PRIO
Major prion protein

2

1

Small-scale

0.621

High

772556

IRS1
Insulin receptor substrate 1

1

20

Small-scale

0.618

High

813519

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

932044

EPHB2
Ephrin type-B receptor 2

1

20

Small-scale

0.618

High

1010411

IRS2
Insulin receptor substrate 2

1

20

Small-scale

0.618

High

1028469

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.618

High

1193728

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

20

Small-scale

0.618

High

1221229

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.618

High

1221257

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.618

High

1221258

SH2B2
SH2B adapter protein 2

1

20

Small-scale

0.618

High

236367

O54737
BCA protein

1

20

High-throughput

0.590

High

699355

VAV
Proto-oncogene vav

1

20

High-throughput

0.590

High

778167

BTK
Tyrosine-protein kinase BTK

1

20

High-throughput

0.590

High

1221220

VAV2
Guanine nucleotide exchange factor VAV2

1

20

High-throughput

0.590

High

1221259

CD2AP
CD2-associated protein

1

19

High-throughput

0.590

High

1221267

GAB2
GRB2-associated-binding protein 2

1

20

High-throughput

0.590

High

1221247

AJUBA
LIM domain-containing protein ajuba

2

20

Small-scale

0.584

High

1221260

SPY2
Protein sprouty homolog 2

2

15

Small-scale

0.584

High

1221261

SPY1
Protein sprouty homolog 1

2

15

Small-scale

0.584

High

449217

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

20

Small-scale

0.575

High

575630

EPOR
Erythropoietin receptor

1

20

Small-scale

0.575

High

632514

KPCA
Protein kinase C alpha type

1

20

Small-scale

0.575

High

849100

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

High-throughput

0.575

High

1221224

DLG4
Disks large homolog 4

1

19

High-throughput

0.575

High

1221238

DOCK1
Dedicator of cytokinesis protein 1

1

20

Small-scale

0.575

High

1221235

THMS1
Protein THEMIS

2

2

Small-scale

0.571

High

1221222

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

20

Small-scale

0.561

High

1189573

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

Small-scale

0.552

High

1221226

SYPH
Synaptophysin

1

0

Small-scale

0.537

High

1022121

DAB2
Disabled homolog 2

1

20

Small-scale

0.536

High

858184

MERL
Merlin

1

20

Small-scale

0.515

High

1221264

SPY4
Protein sprouty homolog 4

1

15

Small-scale

0.515

High

810522

DYN1
Dynamin-1

1

20

Small-scale

0.514

High

1221239

DYN3
Dynamin-3

1

20

Small-scale

0.514

High

1197969

KI26A
Kinesin-like protein KIF26A

1

15

Small-scale

0.506

High

1221230

BTLA
B- and T-lymphocyte attenuator

1

0

Small-scale

0.505

High

1221231

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

9

Small-scale

0.501

High

907957

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.481

High

966008

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

20

High-throughput

0.481

High

993846

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

1190302

SF3B2
Splicing factor 3B subunit 2

1

1

High-throughput

0.481

High

1221228

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

12

High-throughput

0.481

High

1221243

RBM4
RNA-binding protein 4

1

7

High-throughput

0.481

High

1221244

PSPC1
Paraspeckle component 1

1

13

High-throughput

0.481

High

1221253

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

4

High-throughput

0.481

High

205318

AP1B1
AP-1 complex subunit beta-1

1

18

Small-scale

0.479

High

312332

ZN106
Zinc finger protein 106

1

1

Small-scale

0.479

High

821233

CSF3R
Granulocyte colony-stimulating factor receptor

1

20

Small-scale

0.479

High

986921

YBOX1
Y-box-binding protein 1

1

1

High-throughput

0.479

High

1190918

SPRY3
Protein sprouty homolog 3

1

15

Small-scale

0.479

High

1221219

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

Small-scale

0.479

High

1221232

FACD2
Fanconi anemia group D2 protein homolog

1

4

High-throughput

0.479

High

1221233

WDTC1
WD and tetratricopeptide repeats protein 1

1

11

High-throughput

0.479

High

1221234

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

10

High-throughput

0.479

High

1221240

A16L1
Autophagy-related protein 16-1

1

19

High-throughput

0.479

High

1221254

RAB13
Ras-related protein Rab-13

1

7

Small-scale

0.479

High

1221263

DOK3
Docking protein 3

1

20

Small-scale

0.479

High

1221265

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

20

Small-scale

0.479

High

1204339

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.460

High

1221252

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.460

High

86322

B9EKI5
E3 ubiquitin-protein ligase CBL

1

20

High-throughput

0.457

High

1221245

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.457

High

1221249

Q91ZZ2
CRK SH3-binding GNRP

1

20

High-throughput

0.457

High

1221250

ERRFI
ERBB receptor feedback inhibitor 1

1

20

High-throughput

0.457

High

1221255

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

8

High-throughput

0.457

High

1221266

PDC6I
Programmed cell death 6-interacting protein

1

20

High-throughput

0.457

High

968501

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

9

Small-scale

0.445

High

1190026

GARE1
GRB2-associated and regulator of MAPK protein

1

6

Small-scale

0.445

High

1190914

SCIMP
SLP adapter and CSK-interacting membrane protein

1

3

Small-scale

0.445

High

1191334

CARL2
Capping protein, Arp2/3 and myosin-I linker protein 2

1

7

Small-scale

0.445

High

1221227

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

18

Small-scale

0.445

High

1221236

ELMO2
Engulfment and cell motility protein 2

1

4

Small-scale

0.445

High

107033

F8VPP8
Zinc finger CCCH type containing 7B

1

20

High-throughput

0.439

High

1221242

CSTFT
Cleavage stimulation factor subunit 2 tau variant

1

10

High-throughput

0.439

High

1221237

Q8BIS2
IF rod domain-containing protein

1

17

High-throughput

0.437

High

1221246

SATB2
DNA-binding protein SATB2

1

0

Small-scale

0.426

High

1221251

UCK2
Uridine-cytidine kinase 2

1

1

High-throughput

0.417

High

551433

A4
Amyloid-beta precursor protein

1

11

Small-scale

0.408

High

59989

A2BGG7
Y box protein 1

1

1

High-throughput

0.407

High

1133331

Q148Q7
IF rod domain-containing protein

1

16

High-throughput

0.407

High

1221248

SNX18
Sorting nexin-18

1

20

Small-scale

0.407

High


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Last updated: 11Aug2025