HitPredict

Interactor 1: PK3CA (P42337)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: Pik3ca

Interactor 2: P55G (Q64143)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: Pik3r3

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~PI3_PI4_kinase, PI3_PI4_kinase~SH2, PI3K_C2~PI3K_P85_iSH2, PI3K_C2~SH2, PI3K_P85_iSH2~PI3K_p85B, PI3K_P85_iSH2~PI3Ka, PI3Ka~SH2
Common GO terms	GO:0005942 - phosphatidylinositol 3-kinase complex GO:0008286 - insulin receptor signaling pathway GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0046854 - phosphatidylinositol phosphate biosynthetic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1068 Mm			1 461
+	Hs
		787279 PK3CA_HUMAN (1-1068): 0: 1315: 98.69		P55G_HUMAN (1-461): 3.8e-142: 416: 95.88
+	Hs
		126198 PK3CD_HUMAN (1-1065): 0: 1167: 39.72		P55G_HUMAN (1-461): 3.8e-142: 416: 95.88
+	Mm
		1145021 PK3CB_MOUSE (1-1065): 0: 1070: 38.57		P55G_MOUSE (1-461): 6.33e-142: 416: 100.00
+	Hs
		787386 PK3CB_HUMAN (1-1065): 0: 1050: 39.40		P55G_HUMAN (1-461): 3.8e-142: 416: 95.88
+	Hs
		411630 PK3CA_HUMAN (1-1068): 0: 1315: 98.69		LCK_HUMAN (235-458): 4.86e-38: 146: 18.97
+	Hs
		522837 PK3CA_HUMAN (1-1068): 0: 1315: 98.69		SRC_HUMAN (297-459): 1.45e-32: 131: 21.51
+	Bt
		619993 PK3CA_BOVIN (1-1068): 0: 1317: 98.88		P85B_BOVIN (55-161): 1.24e-22: 103: 36.11
+	Hs
		129230 PK3CA_HUMAN (1-1068): 0: 1315: 98.69		P85B_HUMAN (55-161): 1.23e-22: 103: 36.11
+	Bt
		619995 PK3CA_BOVIN (1-1068): 0: 1317: 98.88		P85A_BOVIN (55-166): 4.59e-21: 98.4: 36.28
+	Hs
		655251 PK3CA_HUMAN (1-1068): 0: 1315: 98.69		P85A_HUMAN (55-166): 3.2e-21: 98.8: 36.28
+	Mm
		643067 PK3CA_MOUSE (1-1068): 0: 1314: 100.00		P85A_MOUSE (55-166): 3.32e-21: 98.8: 36.28
+	Mm
		782842 PK3CA_MOUSE (1-1068): 0: 1314: 100.00		CSK_MOUSE (329-451): 2.59e-13: 73.7: 30.00
+	Hs
		126184 PK3CD_HUMAN (1-1065): 0: 1167: 39.72		P85B_HUMAN (55-161): 1.23e-22: 103: 36.11
+	Hs
		126190 PK3CD_HUMAN (1-1065): 0: 1167: 39.72		P85A_HUMAN (55-166): 3.2e-21: 98.8: 36.28
+	Mm
		193568 PK3CD_MOUSE (1-1065): 0: 1163: 39.72		P85A_MOUSE (55-166): 3.32e-21: 98.8: 36.28
+	Hs
		101790 F8W9P4_HUMAN (1-1065): 0: 1112: 37.59		P85A_HUMAN (55-166): 3.2e-21: 98.8: 36.28
+	Mm
		643106 PK3CB_MOUSE (1-1065): 0: 1070: 38.57		P85A_MOUSE (55-166): 3.32e-21: 98.8: 36.28
+	Hs
		129231 PK3CB_HUMAN (1-1065): 0: 1050: 39.40		P85B_HUMAN (55-161): 1.23e-22: 103: 36.11
+	Hs
		655252 PK3CB_HUMAN (1-1065): 0: 1050: 39.40		P85A_HUMAN (55-166): 3.2e-21: 98.8: 36.28
+	Dm
		113886 P91634_DROME (7-1065): 0: 954: 34.49		M9PAY7_DROME (54-182): 1.41e-26: 107: 23.85